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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: E2F5

Summary for E2F5

Gene information	Gene symbol	E2F5
	Ensembl ID	ENSG00000133740
	Entrez ID	1875
	Gene name	E2F transcription factor 5
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q15329

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Dataset with differentially expressed gene: E2F5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.332666	4.00e-33

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Expression of E2F5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to E2F5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating E2F5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
E2F5	hsa-miR-181c-5p	92.6443	NM_001083588
E2F5	hsa-miR-181d-5p	92.6443	NM_001083588
E2F5	hsa-miR-181b-5p	92.6443	NM_001083588
E2F5	hsa-miR-548ax	92.2827	NM_001083589
E2F5	hsa-miR-548ao-5p	92.2827	NM_001083589
E2F5	hsa-miR-7151-3p	92.0265	NM_001083589
E2F5	hsa-miR-4276	91.8468	NM_001083589
E2F5	hsa-miR-545-5p	91.5052	NM_001083588
E2F5	hsa-miR-4752	90.9539	NM_001083589
E2F5	hsa-miR-205-5p	90.5537	NM_001083588
E2F5	hsa-miR-3609	90.4295	NM_001083588
E2F5	hsa-miR-548ah-5p	90.4295	NM_001083588
E2F5	hsa-let-7a-3p	89.8687	NM_001083588
E2F5	hsa-let-7f-1-3p	89.8687	NM_001083588
E2F5	hsa-let-7b-3p	89.8687	NM_001083588
E2F5	hsa-miR-98-3p	89.8687	NM_001083588
E2F5	hsa-miR-3191-3p	89.5313	NM_001083589
E2F5	hsa-miR-4666a-3p	89.198	NM_001083588
E2F5	hsa-miR-4672	88.4871	NM_001083589
E2F5	hsa-miR-5588-3p	86.9358	NM_001083588
E2F5	hsa-miR-12117	86.919	NM_001083589
E2F5	hsa-miR-129-2-3p	86.8539	NM_001083588
E2F5	hsa-miR-129-1-3p	86.8539	NM_001083588
E2F5	hsa-miR-124-3p	86.3745	NM_001083588
E2F5	hsa-miR-506-3p	86.3745	NM_001083588
E2F5	hsa-miR-206	86.3702	NM_001083589
E2F5	hsa-miR-1-3p	86.3702	NM_001083589
E2F5	hsa-miR-6866-5p	86.3623	NM_001083588
E2F5	hsa-miR-4438	85.9394	NM_001083589
E2F5	hsa-miR-505-3p	85.7937	NM_001083589
E2F5	hsa-miR-877-5p	85.7583	NM_001083588
E2F5	hsa-miR-4477a	85.5086	NM_001083589
E2F5	hsa-miR-513b-5p	85.039	NM_001083589
E2F5	hsa-miR-569	84.5552	NM_001083588
E2F5	hsa-miR-5010-3p	84.4453	NM_001083588
E2F5	hsa-miR-212-3p	83.6826	NM_001083589
E2F5	hsa-miR-132-3p	83.6826	NM_001083589
E2F5	hsa-miR-548c-3p	83.6449	NM_001083589
E2F5	hsa-miR-2053	82.2386	NM_001083588
E2F5	hsa-miR-7159-5p	82.0636	NM_001083589
E2F5	hsa-miR-4307	81.5601	NM_001083589
E2F5	hsa-miR-2113	81.3091	NM_001083588
E2F5	hsa-miR-6837-3p	81.3084	NM_001083588
E2F5	hsa-miR-758-5p	80.8408	NM_001083589
E2F5	hsa-miR-7158-3p	80.3876	NM_001083589

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Motifs and transcription factors (TFs) regulating E2F5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
E2F5	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
E2F5	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
E2F5	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
E2F5	transfac_pro__M04918	EGR1 (directAnnotation).
E2F5	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
E2F5	metacluster_7.13	ZFX (directAnnotation).
E2F5	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
E2F5	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
E2F5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
E2F5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
E2F5	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
E2F5	cisbp__M00249	WT1 (directAnnotation).
E2F5	cisbp__M01863	ZNF711 (inferredBy_Orthology).
E2F5	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
E2F5	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
E2F5	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
E2F5	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
E2F5	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
E2F5	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."