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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DPP8

Summary for DPP8

Gene information	Gene symbol	DPP8
	Ensembl ID	ENSG00000074603
	Entrez ID	54878
	Gene name	dipeptidyl peptidase 8
	Synonyms	DP8\|DPRP1\|FLJ14920\|FLJ20283\|MGC26191\|MSTP141
	Gene type	protein_coding
	UniProtAcc	Q6V1X1

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Dataset with differentially expressed gene: DPP8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.254931	7.85e-23

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Expression of DPP8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DPP8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DPP8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DPP8	hsa-miR-5011-5p	82.8662	NM_001320875
DPP8	hsa-miR-627-3p	82.794	NM_197961
DPP8	hsa-miR-579-3p	82.3637	NM_197961
DPP8	hsa-miR-664b-3p	82.3637	NM_197961
DPP8	hsa-miR-633	82.2719	NM_197961
DPP8	hsa-miR-485-5p	82.1098	NM_001320875
DPP8	hsa-miR-1207-5p	81.8392	NM_001320875
DPP8	hsa-miR-3619-5p	81.769	NM_001320875
DPP8	hsa-miR-548aq-3p	81.4969	NM_001320875
DPP8	hsa-miR-548ae-3p	81.4969	NM_001320875
DPP8	hsa-miR-548j-3p	81.4969	NM_001320875
DPP8	hsa-miR-548ah-3p	81.4969	NM_001320875
DPP8	hsa-miR-548am-3p	81.4969	NM_001320875
DPP8	hsa-miR-4266	81.1651	NM_197961
DPP8	hsa-miR-6780b-5p	80.8303	NM_197961
DPP8	hsa-miR-4725-3p	80.8303	NM_197961
DPP8	hsa-miR-4763-5p	80.8034	NM_001320875
DPP8	hsa-miR-575	80.7251	NM_001320875
DPP8	hsa-miR-4676-5p	80.7251	NM_001320875
DPP8	hsa-miR-6742-5p	80.4256	NM_197961
DPP8	hsa-miR-889-3p	80.175	NM_197961
DPP8	hsa-miR-33a-3p	80.092	NM_001320875

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Motifs and transcription factors (TFs) regulating DPP8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DPP8	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DPP8	metacluster_7.13	ZFX (directAnnotation).
DPP8	cisbp__M00968	MTF2 (directAnnotation).
DPP8	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DPP8	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DPP8	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DPP8	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DPP8	cisbp__M00788	ZFY (inferredBy_Orthology).
DPP8	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DPP8	metacluster_175.1	ZNF283 (directAnnotation).
DPP8	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DPP8	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DPP8	metacluster_151.2	ZNF23 (directAnnotation).
DPP8	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DPP8	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."