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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DOCK3

Summary for DOCK3

Gene information	Gene symbol	DOCK3
	Ensembl ID	ENSG00000088538
	Entrez ID	1795
	Gene name	dedicator of cytokinesis 3
	Synonyms	KIAA0299\|MOCA\|PBP
	Gene type	protein_coding
	UniProtAcc	Q8IZD9

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Dataset with differentially expressed gene: DOCK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.31473	4.28e-03

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Expression of DOCK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DOCK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DOCK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DOCK3	hsa-miR-6841-3p	86.3072	NM_004947
DOCK3	hsa-miR-4731-3p	86.0804	NM_004947
DOCK3	hsa-miR-5703	84.815	NM_004947
DOCK3	hsa-miR-4434	84.815	NM_004947
DOCK3	hsa-miR-301a-3p	84.5803	NM_004947
DOCK3	hsa-miR-301b-3p	84.5803	NM_004947
DOCK3	hsa-miR-4295	84.5803	NM_004947
DOCK3	hsa-miR-130a-3p	84.5803	NM_004947
DOCK3	hsa-miR-130b-3p	84.5803	NM_004947
DOCK3	hsa-miR-3666	84.5803	NM_004947
DOCK3	hsa-miR-10393-3p	84.2355	NM_004947
DOCK3	hsa-miR-6801-5p	84.2355	NM_004947
DOCK3	hsa-miR-4722-5p	83.9401	NM_004947
DOCK3	hsa-miR-302d-5p	83.8316	NM_004947
DOCK3	hsa-miR-302b-5p	83.8316	NM_004947
DOCK3	hsa-miR-4495	83.7165	NM_004947
DOCK3	hsa-miR-3151-5p	83.6857	NM_004947
DOCK3	hsa-miR-3173-5p	83.1726	NM_004947
DOCK3	hsa-miR-6799-3p	83.1726	NM_004947
DOCK3	hsa-miR-4274	82.7339	NM_004947
DOCK3	hsa-miR-2115-5p	82.629	NM_004947
DOCK3	hsa-miR-4678	82.6282	NM_004947
DOCK3	hsa-miR-338-5p	82.0925	NM_004947
DOCK3	hsa-miR-3116	81.9821	NM_004947
DOCK3	hsa-miR-6768-5p	81.8826	NM_004947
DOCK3	hsa-miR-4729	81.5101	NM_004947
DOCK3	hsa-miR-3620-3p	81.3908	NM_004947
DOCK3	hsa-miR-4671-3p	80.8879	NM_004947
DOCK3	hsa-miR-5002-3p	80.8668	NM_004947
DOCK3	hsa-miR-6871-3p	80.8274	NM_004947
DOCK3	hsa-miR-1284	80.2457	NM_004947
DOCK3	hsa-miR-3120-5p	80.1942	NM_004947

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Motifs and transcription factors (TFs) regulating DOCK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DOCK3	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
DOCK3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DOCK3	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
DOCK3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
DOCK3	transfac_pro__M04617	ZBTB7A (directAnnotation).
DOCK3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
DOCK3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DOCK3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
DOCK3	transfac_pro__M07387	ZBTB7A (directAnnotation).
DOCK3	transfac_pro__M07436	WT1 (directAnnotation).
DOCK3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
DOCK3	transfac_pro__M00716	ZBTB14 (directAnnotation).
DOCK3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
DOCK3	hdpi__HIP2	UBE2K (directAnnotation).
DOCK3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
DOCK3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DOCK3	transfac_pro__M04893	TAF1 (directAnnotation).
DOCK3	transfac_pro__M03876	ZBTB33 (directAnnotation).
DOCK3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
DOCK3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DOCK3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
DOCK3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DOCK3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."