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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DLC1

Summary for DLC1

Gene information	Gene symbol	DLC1
	Ensembl ID	ENSG00000164741
	Entrez ID	10395
	Gene name	DLC1 Rho GTPase activating protein
	Synonyms	ARHGAP7\|DLC-1\|HP\|p122-RhoGAP\|STARD12
	Gene type	protein_coding
	UniProtAcc	Q96QB1

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Dataset with differentially expressed gene: DLC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.378363	3.45e-19
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.346385	7.71e-18
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.331756	0.00e+00

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Expression of DLC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DLC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DLC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DLC1	hsa-miR-4325	86.2523	NM_001316668
DLC1	hsa-miR-944	86.0147	NM_024767
DLC1	hsa-miR-24-3p	85.8896	NM_001164271
DLC1	hsa-miR-7152-5p	84.9334	NM_001164271
DLC1	hsa-miR-186-5p	84.7432	NM_001316668
DLC1	hsa-miR-4708-5p	84.7214	NM_001316668
DLC1	hsa-miR-8084	84.7183	NM_024767
DLC1	hsa-miR-6739-5p	84.1017	NM_001164271
DLC1	hsa-miR-6733-5p	84.1017	NM_001164271
DLC1	hsa-miR-4671-3p	83.8583	NM_001164271
DLC1	hsa-miR-3200-5p	83.8466	NM_001316668
DLC1	hsa-miR-664a-3p	83.5525	NM_024767
DLC1	hsa-miR-4662a-3p	83.1427	NM_024767
DLC1	hsa-miR-6756-5p	82.7605	NM_001316668
DLC1	hsa-miR-6766-5p	82.7605	NM_001316668
DLC1	hsa-miR-6828-5p	82.6368	NM_001164271
DLC1	hsa-miR-6074	82.3325	NM_024767
DLC1	hsa-miR-1911-5p	82.2523	NM_001164271
DLC1	hsa-miR-4509	82.2381	NM_001316668
DLC1	hsa-miR-19a-3p	81.8646	NM_001164271
DLC1	hsa-miR-19b-3p	81.8646	NM_001164271
DLC1	hsa-miR-504-5p	81.597	NM_001164271
DLC1	hsa-miR-3153	81.2674	NM_001164271
DLC1	hsa-miR-3928-3p	80.935	NM_001316668
DLC1	hsa-miR-4694-3p	80.6742	NM_001316668
DLC1	hsa-miR-513b-5p	80.2759	NM_001164271

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Motifs and transcription factors (TFs) regulating DLC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DLC1	jaspar__MA0079.5	SP1 (directAnnotation).
DLC1	transfac_pro__M01253	CNOT3 (directAnnotation).
DLC1	hdpi__NFIX	NFIX (directAnnotation).
DLC1	transfac_pro__M04817	ZBTB33 (directAnnotation).
DLC1	cisbp__M07938	E2F1 (directAnnotation).
DLC1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
DLC1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
DLC1	metacluster_22.34	BACH2 (directAnnotation).
DLC1	metacluster_74.23	HNF1B (inferredBy_Orthology).
DLC1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
DLC1	metacluster_22.37	BACH1 (directAnnotation).
DLC1	metacluster_22.13	MAFK (inferredBy_Orthology).
DLC1	metacluster_22.18	BACH2 (inferredBy_Orthology).
DLC1	transfac_pro__M06181	ZNF165 (directAnnotation).
DLC1	taipale_tf_pairs__TEAD4_CLOCK_GGWATGNNNNNNNCACGTGN_CAP_repr	CLOCK; TEAD4 (directAnnotation).
DLC1	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
DLC1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
DLC1	metacluster_22.32	NFE2L2 (directAnnotation).
DLC1	tfdimers__MD00561	CRX (directAnnotation).
DLC1	transfac_pro__M12697	ZNF142 (directAnnotation).
DLC1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
DLC1	jaspar__MA1650.1	ZBTB14 (directAnnotation).
DLC1	transfac_pro__M03806	ZBTB7C (directAnnotation).
DLC1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
DLC1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
DLC1	transfac_pro__M00322	MAX; MYC (directAnnotation).
DLC1	tfdimers__MD00483	ZBTB14 (directAnnotation).
DLC1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
DLC1	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
DLC1	tfdimers__MD00364	WT1 (directAnnotation).
DLC1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DLC1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
DLC1	transfac_pro__M06609	ZKSCAN4 (directAnnotation).
DLC1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DLC1	metacluster_175.5	IRX3; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP53; TP63; TP63; TP63; TP63; TP63; TP63; TP73; TP73; TP73; TP73; TP73; TP73 (directAnnotation). TP53; TP53; TP53; TP73 (inferredBy_Orthology).
DLC1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."