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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DICER1

Summary for DICER1

Gene information	Gene symbol	DICER1
	Ensembl ID	ENSG00000100697
	Entrez ID	23405
	Gene name	dicer 1, ribonuclease III
	Synonyms	Dicer\|HERNA\|K12H4.8-LIKE\|KIAA0928\|MNG1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DICER1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.3315	3.08e-30

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Expression of DICER1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DICER1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
DICER1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating DICER1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DICER1	hsa-miR-130a-3p	91.24	NM_001195573
DICER1	hsa-miR-4699-3p	91.0362	NM_001195573
DICER1	hsa-miR-4696	90.3803	NM_001195573
DICER1	hsa-miR-4310	90.3498	NM_001195573
DICER1	hsa-miR-3666	90.1606	NM_001195573
DICER1	hsa-miR-4295	90.1606	NM_001195573
DICER1	hsa-miR-130b-3p	90.1606	NM_001195573
DICER1	hsa-miR-301a-3p	90.1606	NM_001195573
DICER1	hsa-miR-301b-3p	90.1606	NM_001195573
DICER1	hsa-miR-338-5p	89.9927	NM_001291628
DICER1	hsa-miR-3194-5p	89.6005	NM_001195573
DICER1	hsa-miR-4307	89.4011	NM_001195573
DICER1	hsa-miR-582-5p	89.0799	NM_001195573
DICER1	hsa-miR-5008-3p	88.8609	NM_001195573
DICER1	hsa-miR-122-5p	88.6408	NM_001195573
DICER1	hsa-miR-4434	88.4789	NM_001195573
DICER1	hsa-miR-5703	88.4789	NM_001195573
DICER1	hsa-miR-4516	88.4789	NM_001195573
DICER1	hsa-miR-6882-5p	88.1205	NM_001195573
DICER1	hsa-miR-1250-3p	87.8883	NM_001291628
DICER1	hsa-miR-3662	87.8821	NM_001291628
DICER1	hsa-miR-6503-3p	87.269	NM_001291628
DICER1	hsa-miR-29a-3p	87.2372	NM_001195573
DICER1	hsa-miR-29c-3p	87.2372	NM_001195573
DICER1	hsa-miR-29b-3p	87.2372	NM_001195573
DICER1	hsa-miR-3133	86.9056	NM_001195573
DICER1	hsa-miR-4668-5p	86.8678	NM_001195573
DICER1	hsa-miR-425-5p	86.8316	NM_001291628
DICER1	hsa-miR-4500	86.7677	NM_001195573
DICER1	hsa-miR-19a-3p	86.5401	NM_001291628
DICER1	hsa-miR-19b-3p	86.5401	NM_001291628
DICER1	hsa-miR-6835-3p	86.4133	NM_001195573
DICER1	hsa-miR-5692a	86.4066	NM_001195573
DICER1	hsa-miR-7157-5p	86.1967	NM_001195573
DICER1	hsa-miR-6511b-5p	85.8488	NM_001195573
DICER1	hsa-miR-6811-5p	85.8488	NM_001195573
DICER1	hsa-miR-548ah-3p	85.6322	NM_001291628
DICER1	hsa-miR-548ae-3p	85.6322	NM_001291628
DICER1	hsa-miR-548aq-3p	85.6322	NM_001291628
DICER1	hsa-miR-548j-3p	85.6322	NM_001291628
DICER1	hsa-miR-548am-3p	85.6322	NM_001291628
DICER1	hsa-miR-4422	85.4317	NM_001195573
DICER1	hsa-miR-6889-3p	85.1949	NM_001195573
DICER1	hsa-miR-371b-5p	85.1939	NM_001291628
DICER1	hsa-miR-373-5p	85.1939	NM_001291628
DICER1	hsa-miR-616-5p	85.1939	NM_001291628
DICER1	hsa-miR-578	85.0073	NM_001291628
DICER1	hsa-miR-5700	84.9145	NM_001195573
DICER1	hsa-miR-580-5p	84.7204	NM_001291628
DICER1	hsa-miR-586	84.4376	NM_001291628

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Motifs and transcription factors (TFs) regulating DICER1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DICER1	metacluster_135.11	NR2C2 (directAnnotation).
DICER1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DICER1	tfdimers__MD00038	TFAP2C (directAnnotation).
DICER1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DICER1	metacluster_7.13	ZFX (directAnnotation).
DICER1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DICER1	cisbp__M00968	MTF2 (directAnnotation).
DICER1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DICER1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DICER1	cisbp__M00341	PAX6 (directAnnotation).
DICER1	metacluster_198.3	ZFP64 (directAnnotation).
DICER1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DICER1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DICER1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DICER1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DICER1	cisbp__M00788	ZFY (inferredBy_Orthology).
DICER1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DICER1	metacluster_175.1	ZNF283 (directAnnotation).
DICER1	hdpi__ZNF304	ZNF304 (directAnnotation).
DICER1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DICER1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DICER1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DICER1	transfac_pro__M01199	TRIM28 (directAnnotation).
DICER1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DICER1	metacluster_151.2	ZNF23 (directAnnotation).
DICER1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DICER1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DICER1	transfac_pro__M03806	ZBTB7C (directAnnotation).
DICER1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."