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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCX

Summary for DCX

Gene information	Gene symbol	DCX
	Ensembl ID	ENSG00000077279
	Entrez ID	1641
	Gene name	doublecortin
	Synonyms	DBCN\|DC\|LISX\|SCLH\|XLIS
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: DCX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.306369	0.00e+00

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Expression of DCX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCX	hsa-miR-5696	90.0303	NM_000555
DCX	hsa-miR-7843-5p	89.9894	NM_000555
DCX	hsa-miR-4533	89.9811	NM_000555
DCX	hsa-miR-6882-5p	89.898	NM_000555
DCX	hsa-miR-586	89.5208	NM_000555
DCX	hsa-miR-5693	89.5194	NM_000555
DCX	hsa-miR-524-5p	89.5039	NM_000555
DCX	hsa-miR-520d-5p	89.5039	NM_000555
DCX	hsa-miR-4516	89.2325	NM_000555
DCX	hsa-miR-5692a	89.1718	NM_000555
DCX	hsa-miR-3134	89.1411	NM_000555
DCX	hsa-miR-6810-5p	89.1219	NM_000555
DCX	hsa-miR-3686	88.4352	NM_000555
DCX	hsa-miR-7850-5p	88.3319	NM_000555
DCX	hsa-miR-6072	88.1308	NM_000555
DCX	hsa-miR-628-5p	87.9754	NM_000555
DCX	hsa-miR-3065-5p	87.5911	NM_000555
DCX	hsa-miR-577	87.4203	NM_000555
DCX	hsa-miR-6864-5p	87.0819	NM_000555
DCX	hsa-miR-3529-3p	86.941	NM_000555
DCX	hsa-miR-6130	86.5522	NM_000555
DCX	hsa-miR-4510	86.5522	NM_000555
DCX	hsa-miR-6133	86.5522	NM_000555
DCX	hsa-miR-6127	86.5522	NM_000555
DCX	hsa-miR-6129	86.5522	NM_000555
DCX	hsa-miR-17-3p	86.5317	NM_000555
DCX	hsa-miR-4306	86.3793	NM_000555
DCX	hsa-miR-6081	86.0468	NM_000555
DCX	hsa-miR-4303	85.8287	NM_000555
DCX	hsa-miR-3926	85.5078	NM_000555
DCX	hsa-miR-570-3p	85.2618	NM_000555
DCX	hsa-miR-183-5p	85.2358	NM_000555
DCX	hsa-miR-4999-5p	85.2201	NM_000555
DCX	hsa-miR-1290	85.204	NM_000555
DCX	hsa-miR-3115	85.1862	NM_000555
DCX	hsa-miR-6865-5p	84.8145	NM_000555
DCX	hsa-miR-6815-5p	84.8145	NM_000555
DCX	hsa-miR-216a-3p	84.6314	NM_000555
DCX	hsa-miR-128-3p	84.6314	NM_000555
DCX	hsa-miR-12125	84.5971	NM_000555
DCX	hsa-miR-4311	84.4077	NM_000555
DCX	hsa-miR-1252-3p	84.395	NM_000555
DCX	hsa-miR-3187-3p	84.1051	NM_000555
DCX	hsa-miR-7152-5p	83.8561	NM_000555
DCX	hsa-miR-4499	83.7581	NM_000555
DCX	hsa-miR-6891-3p	83.6856	NM_000555
DCX	hsa-miR-4753-3p	83.424	NM_000555
DCX	hsa-miR-138-2-3p	83.3412	NM_000555
DCX	hsa-miR-548c-3p	83.1702	NM_000555
DCX	hsa-miR-4534	83.0897	NM_000555

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Motifs and transcription factors (TFs) regulating DCX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."