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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCUN1D1

Summary for DCUN1D1

Gene information	Gene symbol	DCUN1D1
	Ensembl ID	ENSG00000043093
	Entrez ID	54165
	Gene name	defective in cullin neddylation 1 domain containing 1
	Synonyms	DCUN1L1\|RP42\|SCCRO\|SCRO\|Tes3
	Gene type	protein_coding
	UniProtAcc	Q96GG9

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Dataset with differentially expressed gene: DCUN1D1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.316084	8.54e-40
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.356428	1.81e-10
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.25257	1.06e-25

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Expression of DCUN1D1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCUN1D1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCUN1D1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCUN1D1	hsa-miR-1271-5p	89.5163	NM_001308101
DCUN1D1	hsa-miR-570-3p	89.2663	NM_001308101
DCUN1D1	hsa-miR-4699-3p	89.2145	NM_001308101
DCUN1D1	hsa-miR-622	89.1914	NM_001308101
DCUN1D1	hsa-miR-8087	89.1099	NM_001308101
DCUN1D1	hsa-miR-542-3p	88.7522	NM_001308101
DCUN1D1	hsa-miR-6715a-3p	88.6609	NM_001308101
DCUN1D1	hsa-miR-374b-5p	88.4376	NM_001308101
DCUN1D1	hsa-miR-548n	88.4036	NM_001308101
DCUN1D1	hsa-miR-4729	88.3754	NM_001308101
DCUN1D1	hsa-miR-196a-3p	88.043	NM_001308101
DCUN1D1	hsa-miR-4652-3p	87.9981	NM_001308101
DCUN1D1	hsa-miR-4422	87.9761	NM_001308101
DCUN1D1	hsa-miR-5006-5p	87.5941	NM_001308101
DCUN1D1	hsa-miR-140-3p	87.3701	NM_001308101
DCUN1D1	hsa-miR-548e-5p	87.3173	NM_001308101
DCUN1D1	hsa-let-7c-3p	86.607	NM_001308101
DCUN1D1	hsa-miR-524-5p	86.2878	NM_001308101
DCUN1D1	hsa-miR-520d-5p	86.2878	NM_001308101
DCUN1D1	hsa-miR-4775	86.1211	NM_001308101
DCUN1D1	hsa-miR-3668	85.9178	NM_001308101
DCUN1D1	hsa-miR-7843-3p	85.7236	NM_001308101
DCUN1D1	hsa-miR-106b-5p	85.5115	NM_001308101
DCUN1D1	hsa-miR-20a-5p	85.5115	NM_001308101
DCUN1D1	hsa-miR-3121-3p	84.3287	NM_001308101
DCUN1D1	hsa-miR-33a-3p	84.3187	NM_001308101
DCUN1D1	hsa-miR-3680-3p	84.2093	NM_001308101
DCUN1D1	hsa-miR-4291	84.0901	NM_001308101
DCUN1D1	hsa-miR-510-3p	83.7338	NM_001308101
DCUN1D1	hsa-miR-4328	83.5367	NM_001308101
DCUN1D1	hsa-miR-5007-3p	83.3719	NM_001308101
DCUN1D1	hsa-miR-624-5p	83.1432	NM_001308101
DCUN1D1	hsa-miR-204-3p	83.0863	NM_001308101
DCUN1D1	hsa-miR-4646-5p	83.0863	NM_001308101
DCUN1D1	hsa-miR-3143	83.0259	NM_001308101
DCUN1D1	hsa-miR-600	82.994	NM_001308101
DCUN1D1	hsa-miR-17-5p	82.9715	NM_001308101
DCUN1D1	hsa-miR-519d-3p	82.9715	NM_001308101
DCUN1D1	hsa-miR-93-5p	82.9715	NM_001308101
DCUN1D1	hsa-miR-20b-5p	82.9715	NM_001308101
DCUN1D1	hsa-miR-526b-3p	82.9715	NM_001308101
DCUN1D1	hsa-miR-106a-5p	82.9715	NM_001308101
DCUN1D1	hsa-miR-4502	82.9066	NM_001308101
DCUN1D1	hsa-miR-650	82.9012	NM_001308101
DCUN1D1	hsa-miR-3612	82.9012	NM_001308101
DCUN1D1	hsa-miR-4262	82.3414	NM_001308101
DCUN1D1	hsa-miR-30c-5p	81.6837	NM_001308101
DCUN1D1	hsa-miR-30d-5p	81.6837	NM_001308101
DCUN1D1	hsa-miR-30b-5p	81.6837	NM_001308101
DCUN1D1	hsa-miR-30e-5p	81.6837	NM_001308101

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Motifs and transcription factors (TFs) regulating DCUN1D1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DCUN1D1	metacluster_135.11	NR2C2 (directAnnotation).
DCUN1D1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DCUN1D1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DCUN1D1	metacluster_7.13	ZFX (directAnnotation).
DCUN1D1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DCUN1D1	cisbp__M00968	MTF2 (directAnnotation).
DCUN1D1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DCUN1D1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DCUN1D1	cisbp__M00341	PAX6 (directAnnotation).
DCUN1D1	metacluster_198.3	ZFP64 (directAnnotation).
DCUN1D1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DCUN1D1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DCUN1D1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DCUN1D1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DCUN1D1	cisbp__M00788	ZFY (inferredBy_Orthology).
DCUN1D1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DCUN1D1	metacluster_175.1	ZNF283 (directAnnotation).
DCUN1D1	hdpi__ZNF304	ZNF304 (directAnnotation).
DCUN1D1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DCUN1D1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DCUN1D1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DCUN1D1	transfac_pro__M01199	TRIM28 (directAnnotation).
DCUN1D1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DCUN1D1	metacluster_151.2	ZNF23 (directAnnotation).
DCUN1D1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DCUN1D1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DCUN1D1	transfac_pro__M03806	ZBTB7C (directAnnotation).
DCUN1D1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DCUN1D1	kznf__ZNF273_Imbeault2017_RP_RCADE	ZNF273 (directAnnotation).
DCUN1D1	transfac_pro__M01298	MECP2 (directAnnotation).
DCUN1D1	transfac_pro__M01973	PLAG1 (directAnnotation).
DCUN1D1	transfac_public__M00051	NFKB1 (directAnnotation).
DCUN1D1	jaspar__MA1522.1	MAZ (directAnnotation).
DCUN1D1	taipale_tf_pairs__TEAD4_CEBPD_RGWATGYNNTTRCGYAAN_CAP	CEBPD; TEAD4 (directAnnotation).
DCUN1D1	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).
DCUN1D1	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
DCUN1D1	jaspar__MA1122.1	TFDP1 (directAnnotation).
DCUN1D1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
DCUN1D1	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
DCUN1D1	taipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_repr	FIGLA; GCM1 (directAnnotation).
DCUN1D1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
DCUN1D1	transfac_pro__M01175	ZBTB7B (directAnnotation).
DCUN1D1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
DCUN1D1	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
DCUN1D1	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."