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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCBLD2

Summary for DCBLD2

Gene information	Gene symbol	DCBLD2
	Ensembl ID	ENSG00000057019
	Entrez ID	131566
	Gene name	discoidin, CUB and LCCL domain containing 2
	Synonyms	CLCP1\|ESDN
	Gene type	protein_coding
	UniProtAcc	Q96PD2

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Dataset with differentially expressed gene: DCBLD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.899041	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.266985	3.67e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.561335	1.55e-39
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.43114	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.352616	1.17e-16
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.288313	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.686606	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.302329	0.00e+00

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Expression of DCBLD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCBLD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCBLD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCBLD2	hsa-miR-130a-3p	91.0922	NM_080927
DCBLD2	hsa-miR-6516-5p	90.2232	NM_080927
DCBLD2	hsa-miR-636	90.1456	NM_080927
DCBLD2	hsa-miR-3148	90.0537	NM_080927
DCBLD2	hsa-miR-3129-5p	89.7516	NM_080927
DCBLD2	hsa-miR-199a-3p	89.7516	NM_080927
DCBLD2	hsa-miR-199b-3p	89.7516	NM_080927
DCBLD2	hsa-miR-8485	89.7361	NM_080927
DCBLD2	hsa-miR-484	89.6167	NM_080927
DCBLD2	hsa-miR-450a-1-3p	89.4693	NM_080927
DCBLD2	hsa-miR-200c-3p	89.4316	NM_080927
DCBLD2	hsa-miR-429	89.4316	NM_080927
DCBLD2	hsa-miR-200b-3p	89.4316	NM_080927
DCBLD2	hsa-miR-4310	89.1277	NM_080927
DCBLD2	hsa-miR-186-5p	88.8083	NM_080927
DCBLD2	hsa-miR-20a-5p	88.6242	NM_080927
DCBLD2	hsa-miR-526b-3p	88.6242	NM_080927
DCBLD2	hsa-miR-548n	87.752	NM_080927
DCBLD2	hsa-miR-4753-5p	87.6675	NM_080927
DCBLD2	hsa-miR-494-3p	87.3789	NM_080927
DCBLD2	hsa-miR-519d-3p	87.3468	NM_080927
DCBLD2	hsa-miR-93-5p	87.3468	NM_080927
DCBLD2	hsa-miR-20b-5p	87.3468	NM_080927
DCBLD2	hsa-miR-23b-3p	87.2791	NM_080927
DCBLD2	hsa-miR-23a-3p	87.2791	NM_080927
DCBLD2	hsa-miR-23c	87.2791	NM_080927
DCBLD2	hsa-miR-607	87.1021	NM_080927
DCBLD2	hsa-miR-4261	86.9518	NM_080927
DCBLD2	hsa-let-7b-3p	86.8524	NM_080927
DCBLD2	hsa-miR-98-3p	86.8524	NM_080927
DCBLD2	hsa-let-7f-1-3p	86.8524	NM_080927
DCBLD2	hsa-let-7a-3p	86.8524	NM_080927
DCBLD2	hsa-miR-144-3p	86.5672	NM_080927
DCBLD2	hsa-miR-7157-5p	86.4767	NM_080927
DCBLD2	hsa-miR-9902	86.3558	NM_080927
DCBLD2	hsa-miR-6768-3p	85.5657	NM_080927
DCBLD2	hsa-miR-4782-3p	85.2776	NM_080927
DCBLD2	hsa-miR-6766-3p	85.2776	NM_080927
DCBLD2	hsa-miR-219a-5p	85.2776	NM_080927
DCBLD2	hsa-miR-340-5p	85.0376	NM_080927
DCBLD2	hsa-miR-3646	84.7944	NM_080927
DCBLD2	hsa-miR-147b-5p	84.6164	NM_080927
DCBLD2	hsa-miR-3155b	84.4551	NM_080927
DCBLD2	hsa-miR-3155a	84.4551	NM_080927
DCBLD2	hsa-miR-4429	84.3241	NM_080927
DCBLD2	hsa-miR-320d	84.3241	NM_080927
DCBLD2	hsa-miR-320c	84.3241	NM_080927
DCBLD2	hsa-miR-320a-3p	84.3241	NM_080927
DCBLD2	hsa-miR-320b	84.3241	NM_080927
DCBLD2	hsa-miR-31-5p	84.1896	NM_080927

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Motifs and transcription factors (TFs) regulating DCBLD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DCBLD2	metacluster_7.13	ZFX (directAnnotation).
DCBLD2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
DCBLD2	metacluster_151.2	ZNF23 (directAnnotation).
DCBLD2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
DCBLD2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DCBLD2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
DCBLD2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DCBLD2	transfac_pro__M06071	ZNF814 (directAnnotation).
DCBLD2	transfac_pro__M05628	ZNF735 (directAnnotation).
DCBLD2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
DCBLD2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DCBLD2	jaspar__MA0079.5	SP1 (directAnnotation).
DCBLD2	metacluster_52.11	ZNF184 (directAnnotation).
DCBLD2	metacluster_35.7	HINFP (inferredBy_Orthology).
DCBLD2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
DCBLD2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DCBLD2	cisbp__M00968	MTF2 (directAnnotation).
DCBLD2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DCBLD2	cisbp__M00341	PAX6 (directAnnotation).
DCBLD2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DCBLD2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DCBLD2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
DCBLD2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DCBLD2	cisbp__M00788	ZFY (inferredBy_Orthology).
DCBLD2	hdpi__ZNF304	ZNF304 (directAnnotation).
DCBLD2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DCBLD2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DCBLD2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DCBLD2	transfac_pro__M01199	TRIM28 (directAnnotation).
DCBLD2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DCBLD2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DCBLD2	transfac_pro__M03806	ZBTB7C (directAnnotation).
DCBLD2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DCBLD2	transfac_pro__M04826	EP300 (directAnnotation).
DCBLD2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
DCBLD2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
DCBLD2	cisbp__M08198	ELF1 (directAnnotation).
DCBLD2	jaspar__MA1708.1	ETV7 (directAnnotation).
DCBLD2	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
DCBLD2	hdpi__TP73	TP73 (directAnnotation).
DCBLD2	hdpi__ELF2	ELF2 (directAnnotation).
DCBLD2	metacluster_81.7	CREB1 (directAnnotation).
DCBLD2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
DCBLD2	transfac_pro__M01253	CNOT3 (directAnnotation).
DCBLD2	transfac_pro__M04817	ZBTB33 (directAnnotation).
DCBLD2	cisbp__M07938	E2F1 (directAnnotation).
DCBLD2	transfac_pro__M06181	ZNF165 (directAnnotation).
DCBLD2	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
DCBLD2	jaspar__MA1483.2	ELF2 (directAnnotation).
DCBLD2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."