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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DCAF7

Summary for DCAF7

Gene information	Gene symbol	DCAF7
	Ensembl ID	ENSG00000136485
	Entrez ID	10238
	Gene name	DDB1 and CUL4 associated factor 7
	Synonyms	HAN11\|SWAN-1\|WDR68
	Gene type	protein_coding
	UniProtAcc	P61962

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Dataset with differentially expressed gene: DCAF7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.368525	1.20e-23
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.432311	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.51994	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.462947	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.316326	1.71e-21
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.306157	0.00e+00

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Expression of DCAF7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DCAF7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DCAF7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DCAF7	hsa-miR-5579-3p	86.0636	NM_005828
DCAF7	hsa-miR-6778-3p	85.8683	NM_005828
DCAF7	hsa-miR-4267	85.6523	NM_005828
DCAF7	hsa-miR-6868-3p	85.2494	NM_005828
DCAF7	hsa-miR-6077	85.1156	NM_005828
DCAF7	hsa-miR-5193	85.0005	NM_005828
DCAF7	hsa-miR-2467-3p	84.916	NM_005828
DCAF7	hsa-miR-6882-3p	84.8226	NM_005828
DCAF7	hsa-miR-4271	84.6994	NM_005828
DCAF7	hsa-miR-6876-5p	84.6655	NM_005828
DCAF7	hsa-miR-764	84.3684	NM_005828
DCAF7	hsa-miR-138-1-3p	84.0733	NM_005828
DCAF7	hsa-miR-376c-3p	83.9011	NM_005828
DCAF7	hsa-miR-4492	83.2202	NM_005828
DCAF7	hsa-miR-3914	82.9839	NM_005828
DCAF7	hsa-miR-6779-3p	82.8835	NM_005828
DCAF7	hsa-miR-8485	82.7682	NM_005828
DCAF7	hsa-miR-4666a-3p	82.2932	NM_005828
DCAF7	hsa-miR-939-3p	82.2071	NM_005828
DCAF7	hsa-miR-513a-5p	82.0497	NM_005828
DCAF7	hsa-miR-1284	81.8282	NM_005828
DCAF7	hsa-miR-27b-5p	81.6977	NM_005828
DCAF7	hsa-miR-4496	81.4119	NM_005828
DCAF7	hsa-miR-4701-5p	80.9699	NM_005828
DCAF7	hsa-miR-588	80.9699	NM_005828
DCAF7	hsa-miR-4279	80.883	NM_005828
DCAF7	hsa-miR-9985	80.5854	NM_005828
DCAF7	hsa-miR-27b-3p	80.5854	NM_005828
DCAF7	hsa-miR-27a-3p	80.5854	NM_005828
DCAF7	hsa-miR-5190	80.5406	NM_005828
DCAF7	hsa-miR-4476	80.5134	NM_005828
DCAF7	hsa-miR-5580-5p	80.0114	NM_005828

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Motifs and transcription factors (TFs) regulating DCAF7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DCAF7	metacluster_7.13	ZFX (directAnnotation).
DCAF7	cisbp__M01863	ZNF711 (inferredBy_Orthology).
DCAF7	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DCAF7	hdpi__ETV4	ETV4 (directAnnotation).
DCAF7	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
DCAF7	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
DCAF7	cisbp__M08198	ELF1 (directAnnotation).
DCAF7	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
DCAF7	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
DCAF7	transfac_pro__M04944	GABPA (directAnnotation).
DCAF7	cisbp__M00341	PAX6 (directAnnotation).
DCAF7	metacluster_198.3	ZFP64 (directAnnotation).
DCAF7	jaspar__MA1483.2	ELF2 (directAnnotation).
DCAF7	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
DCAF7	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
DCAF7	transfac_pro__M05706	ZNF20 (directAnnotation).
DCAF7	transfac_pro__M06135	ZNF28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."