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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DACH1

Summary for DACH1

Gene information	Gene symbol	DACH1
	Ensembl ID	ENSG00000276644
	Entrez ID	1602
	Gene name	dachshund family transcription factor 1
	Synonyms	DACH
	Gene type	protein_coding
	UniProtAcc	Q9UI36

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Dataset with differentially expressed gene: DACH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.868944	0.00e+00

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Expression of DACH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DACH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DACH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DACH1	hsa-miR-5580-3p	88.7044	NM_004392
DACH1	hsa-miR-548u	88.4887	NM_004392
DACH1	hsa-miR-1183	88.4824	NM_004392
DACH1	hsa-miR-4699-3p	88.2276	NM_004392
DACH1	hsa-miR-103a-1-5p	88.042	NM_004392
DACH1	hsa-miR-103a-2-5p	88.042	NM_004392
DACH1	hsa-miR-196a-1-3p	87.8997	NM_004392
DACH1	hsa-miR-125a-3p	87.7363	NM_004392
DACH1	hsa-miR-4517	87.6643	NM_004392
DACH1	hsa-miR-4282	87.6517	NM_004392
DACH1	hsa-miR-501-5p	87.5687	NM_004392
DACH1	hsa-miR-30d-3p	87.5212	NM_004392
DACH1	hsa-miR-30a-3p	87.5212	NM_004392
DACH1	hsa-miR-30e-3p	87.5212	NM_004392
DACH1	hsa-miR-4511	87.1772	NM_004392
DACH1	hsa-miR-3674	86.6363	NM_004392
DACH1	hsa-miR-6758-3p	86.6312	NM_004392
DACH1	hsa-miR-302c-5p	86.4655	NM_004392
DACH1	hsa-miR-3163	85.9768	NM_004392
DACH1	hsa-miR-520d-5p	85.9139	NM_004392
DACH1	hsa-miR-524-5p	85.9139	NM_004392
DACH1	hsa-miR-219a-2-3p	85.8645	NM_004392
DACH1	hsa-miR-4668-5p	85.757	NM_004392
DACH1	hsa-miR-5195-3p	85.581	NM_004392
DACH1	hsa-miR-148a-5p	85.3491	NM_004392
DACH1	hsa-miR-500a-5p	85.0518	NM_004392
DACH1	hsa-miR-374c-5p	84.9356	NM_004392
DACH1	hsa-miR-655-3p	84.9356	NM_004392
DACH1	hsa-miR-1468-3p	84.9339	NM_004392
DACH1	hsa-miR-4530	84.8587	NM_004392
DACH1	hsa-miR-651-5p	84.7811	NM_004392
DACH1	hsa-miR-1324	84.6875	NM_004392
DACH1	hsa-miR-622	84.6694	NM_004392
DACH1	hsa-miR-6124	84.5688	NM_004392
DACH1	hsa-miR-5692a	84.2913	NM_004392
DACH1	hsa-miR-642b-5p	83.8419	NM_004392
DACH1	hsa-miR-190a-3p	83.4855	NM_004392
DACH1	hsa-miR-2054	83.4519	NM_004392
DACH1	hsa-miR-6824-3p	83.3348	NM_004392
DACH1	hsa-miR-6764-3p	83.3348	NM_004392
DACH1	hsa-miR-200b-3p	83.2885	NM_004392
DACH1	hsa-miR-429	83.2885	NM_004392
DACH1	hsa-miR-200c-3p	83.2885	NM_004392
DACH1	hsa-miR-6888-5p	82.9937	NM_004392
DACH1	hsa-miR-3978	82.3162	NM_004392
DACH1	hsa-miR-5584-3p	82.1677	NM_004392
DACH1	hsa-miR-4768-3p	82.0898	NM_004392
DACH1	hsa-miR-153-3p	81.6341	NM_004392
DACH1	hsa-miR-5689	81.5997	NM_004392
DACH1	hsa-miR-1-3p	80.7693	NM_004392

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Motifs and transcription factors (TFs) regulating DACH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DACH1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
DACH1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
DACH1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
DACH1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
DACH1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
DACH1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
DACH1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
DACH1	metacluster_3.14	WT1; WT1 (directAnnotation).
DACH1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
DACH1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."