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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CUL3

Summary for CUL3

Gene information	Gene symbol	CUL3
	Ensembl ID	ENSG00000036257
	Entrez ID	8452
	Gene name	cullin 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q13618

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Dataset with differentially expressed gene: CUL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.251198	7.83e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.305294	9.95e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.319342	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.325685	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.346877	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.258361	0.00e+00

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Expression of CUL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CUL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CUL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CUL3	hsa-miR-1252-3p	87.5711	NM_003590
CUL3	hsa-miR-4789-3p	87.5307	NM_001257197
CUL3	hsa-miR-6852-5p	87.5188	NM_003590
CUL3	hsa-miR-601	87.4505	NM_003590
CUL3	hsa-miR-3133	87.3446	NM_001257197
CUL3	hsa-miR-3606-3p	87.1745	NM_001257197
CUL3	hsa-miR-106a-3p	87.1109	NM_001257197
CUL3	hsa-miR-4487	86.8653	NM_003590
CUL3	hsa-miR-5583-3p	86.8627	NM_003590
CUL3	hsa-miR-451b	86.7011	NM_001257197
CUL3	hsa-miR-517-5p	86.4257	NM_003590
CUL3	hsa-miR-2276-3p	86.2629	NM_001257197
CUL3	hsa-miR-892c-5p	85.9823	NM_003590
CUL3	hsa-miR-664a-5p	85.9528	NM_003590
CUL3	hsa-miR-8087	85.9292	NM_003590
CUL3	hsa-miR-6761-5p	85.6568	NM_001257197
CUL3	hsa-miR-4768-5p	85.311	NM_003590
CUL3	hsa-miR-4446-5p	85.2137	NM_001257197
CUL3	hsa-miR-3529-3p	85.176	NM_001257197
CUL3	hsa-miR-558	84.9465	NM_003590
CUL3	hsa-miR-494-3p	84.7949	NM_003590
CUL3	hsa-miR-633	84.7678	NM_003590
CUL3	hsa-miR-4709-5p	84.4831	NM_003590
CUL3	hsa-miR-3160-3p	84.4459	NM_003590
CUL3	hsa-miR-101-3p	84.1414	NM_003590
CUL3	hsa-miR-335-3p	83.7153	NM_001257197
CUL3	hsa-miR-4422	83.4355	NM_003590
CUL3	hsa-miR-651-3p	83.3617	NM_003590
CUL3	hsa-miR-130a-5p	83.2887	NM_003590
CUL3	hsa-miR-137-3p	83.1202	NM_001257197
CUL3	hsa-miR-139-5p	83.0493	NM_001257197
CUL3	hsa-miR-539-3p	83.0482	NM_003590
CUL3	hsa-miR-485-3p	83.0482	NM_003590
CUL3	hsa-miR-3666	83.0335	NM_001257197
CUL3	hsa-miR-1277-5p	82.6229	NM_001257197
CUL3	hsa-miR-4262	82.6026	NM_003590
CUL3	hsa-miR-302e	82.5661	NM_001257197
CUL3	hsa-miR-4646-5p	81.9386	NM_003590
CUL3	hsa-miR-204-3p	81.9386	NM_003590
CUL3	hsa-miR-4528	81.7673	NM_003590
CUL3	hsa-miR-3617-3p	81.5022	NM_003590
CUL3	hsa-let-7c-3p	81.4409	NM_003590
CUL3	hsa-miR-454-3p	80.6621	NM_001257197
CUL3	hsa-miR-7849-3p	80.4713	NM_003590
CUL3	hsa-miR-301a-3p	80.2342	NM_001257197
CUL3	hsa-miR-301b-3p	80.2342	NM_001257197
CUL3	hsa-miR-130b-3p	80.2342	NM_001257197
CUL3	hsa-miR-130a-3p	80.2342	NM_001257197
CUL3	hsa-miR-4295	80.2342	NM_001257197
CUL3	hsa-miR-607	80.088	NM_003590

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Motifs and transcription factors (TFs) regulating CUL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CUL3	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CUL3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CUL3	jaspar__MA0748.2	YY2 (directAnnotation).
CUL3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CUL3	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CUL3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CUL3	cisbp__M00788	ZFY (inferredBy_Orthology).
CUL3	transfac_pro__M00430	E2F1 (directAnnotation).
CUL3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CUL3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CUL3	transfac_pro__M04893	TAF1 (directAnnotation).
CUL3	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
CUL3	transfac_pro__M01199	TRIM28 (directAnnotation).
CUL3	metacluster_7.13	ZFX (directAnnotation).
CUL3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CUL3	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
CUL3	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
CUL3	hdpi__HIP2	UBE2K (directAnnotation).
CUL3	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
CUL3	hdpi__TIMELESS	TIMELESS (directAnnotation).
CUL3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CUL3	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
CUL3	metacluster_191.5	SPDEF (inferredBy_Orthology).
CUL3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CUL3	transfac_pro__M00938	E2F1 (directAnnotation).
CUL3	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
CUL3	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
CUL3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
CUL3	hdpi__RARA	RARA (directAnnotation).
CUL3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CUL3	hdpi__ELF2	ELF2 (directAnnotation).
CUL3	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
CUL3	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
CUL3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CUL3	jaspar__MA1583.1	ZFP57 (directAnnotation).
CUL3	cisbp__M00968	MTF2 (directAnnotation).
CUL3	transfac_pro__M02898	SMAD3 (directAnnotation).
CUL3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CUL3	hdpi__HTATIP2	HTATIP2 (directAnnotation).
CUL3	jaspar__MA1721.1	ZNF93 (directAnnotation).
CUL3	transfac_pro__M04916	TAF1 (directAnnotation).
CUL3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CUL3	jaspar__MA1122.1	TFDP1 (directAnnotation).
CUL3	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
CUL3	transfac_pro__M07310	SP5 (directAnnotation).
CUL3	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CUL3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CUL3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CUL3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CUL3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."