Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CTDSPL2

Summary for CTDSPL2

Gene information	Gene symbol	CTDSPL2
	Ensembl ID	ENSG00000137770
	Entrez ID	51496
	Gene name	CTD small phosphatase like 2
	Synonyms	FLJ10523\|HSPC129
	Gene type	protein_coding
	UniProtAcc	Q05D32

Top

Dataset with differentially expressed gene: CTDSPL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.262366	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.250703	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.285366	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.323742	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.389607	0.00e+00

Top

Expression of CTDSPL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CTDSPL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CTDSPL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CTDSPL2	hsa-miR-548ap-3p	89.1098	NM_016396
CTDSPL2	hsa-miR-548t-3p	89.1098	NM_016396
CTDSPL2	hsa-miR-936	88.8305	NM_016396
CTDSPL2	hsa-let-7c-3p	88.1326	NM_016396
CTDSPL2	hsa-miR-382-5p	88.0387	NM_016396
CTDSPL2	hsa-miR-580-3p	88.0191	NM_016396
CTDSPL2	hsa-miR-12136	87.9002	NM_016396
CTDSPL2	hsa-miR-3692-3p	86.7832	NM_016396
CTDSPL2	hsa-miR-508-3p	86.7249	NM_016396
CTDSPL2	hsa-miR-4795-3p	86.6789	NM_016396
CTDSPL2	hsa-miR-190b-3p	86.6721	NM_016396
CTDSPL2	hsa-miR-221-3p	86.659	NM_016396
CTDSPL2	hsa-miR-222-3p	86.659	NM_016396
CTDSPL2	hsa-miR-4738-3p	86.2103	NM_016396
CTDSPL2	hsa-miR-4801	85.9812	NM_016396
CTDSPL2	hsa-miR-4668-3p	85.9299	NM_016396
CTDSPL2	hsa-miR-6830-3p	85.8696	NM_016396
CTDSPL2	hsa-miR-4755-5p	85.8615	NM_016396
CTDSPL2	hsa-miR-5006-3p	85.8615	NM_016396
CTDSPL2	hsa-miR-577	85.6141	NM_016396
CTDSPL2	hsa-miR-3157-3p	85.5717	NM_016396
CTDSPL2	hsa-miR-194-5p	85.5417	NM_016396
CTDSPL2	hsa-miR-5689	85.4735	NM_016396
CTDSPL2	hsa-miR-4731-3p	85.2378	NM_016396
CTDSPL2	hsa-miR-548f-5p	85.1712	NM_016396
CTDSPL2	hsa-miR-655-3p	85.1439	NM_016396
CTDSPL2	hsa-miR-374c-5p	85.1439	NM_016396
CTDSPL2	hsa-miR-6756-3p	85.0249	NM_016396
CTDSPL2	hsa-miR-3127-3p	85.0249	NM_016396
CTDSPL2	hsa-miR-4661-5p	84.981	NM_016396
CTDSPL2	hsa-miR-548aw	84.0841	NM_016396
CTDSPL2	hsa-miR-6884-3p	83.652	NM_016396
CTDSPL2	hsa-miR-202-3p	82.9756	NM_016396
CTDSPL2	hsa-let-7g-3p	82.8576	NM_016396
CTDSPL2	hsa-let-7a-2-3p	82.8576	NM_016396
CTDSPL2	hsa-miR-335-3p	82.8058	NM_016396
CTDSPL2	hsa-miR-4721	82.5816	NM_016396
CTDSPL2	hsa-miR-429	82.452	NM_016396
CTDSPL2	hsa-miR-200c-3p	82.452	NM_016396
CTDSPL2	hsa-miR-200b-3p	82.452	NM_016396
CTDSPL2	hsa-miR-329-3p	82.2086	NM_016396
CTDSPL2	hsa-miR-9983-3p	81.2886	NM_016396
CTDSPL2	hsa-miR-4254	81.1246	NM_016396
CTDSPL2	hsa-miR-548c-3p	81.0835	NM_016396
CTDSPL2	hsa-miR-1976	81.0127	NM_016396
CTDSPL2	hsa-miR-1197	80.4817	NM_016396
CTDSPL2	hsa-miR-12135	80.1801	NM_016396

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CTDSPL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CTDSPL2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CTDSPL2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CTDSPL2	transfac_pro__M07397	ZNF148 (directAnnotation).
CTDSPL2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CTDSPL2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CTDSPL2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CTDSPL2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CTDSPL2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CTDSPL2	transfac_pro__M01175	ZBTB7B (directAnnotation).
CTDSPL2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CTDSPL2	tfdimers__MD00151	CHURC1 (directAnnotation).
CTDSPL2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CTDSPL2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CTDSPL2	transfac_pro__M01303	SP1 (directAnnotation).
CTDSPL2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CTDSPL2	transfac_pro__M02090	E2F4 (directAnnotation).
CTDSPL2	transfac_pro__M01714	KLF15 (directAnnotation).
CTDSPL2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CTDSPL2	jaspar__MA1122.1	TFDP1 (directAnnotation).
CTDSPL2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CTDSPL2	transfac_pro__M02089	E2F3 (directAnnotation).
CTDSPL2	metacluster_3.14	WT1; WT1 (directAnnotation).
CTDSPL2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CTDSPL2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CTDSPL2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CTDSPL2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CTDSPL2	cisbp__M07938	E2F1 (directAnnotation).
CTDSPL2	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
CTDSPL2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CTDSPL2	transfac_pro__M07436	WT1 (directAnnotation).
CTDSPL2	transfac_pro__M02281	SP1 (directAnnotation).
CTDSPL2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CTDSPL2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CTDSPL2	transfac_pro__M02898	SMAD3 (directAnnotation).
CTDSPL2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CTDSPL2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
CTDSPL2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CTDSPL2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CTDSPL2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CTDSPL2	cisbp__M00788	ZFY (inferredBy_Orthology).
CTDSPL2	transfac_pro__M00430	E2F1 (directAnnotation).
CTDSPL2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CTDSPL2	transfac_pro__M04893	TAF1 (directAnnotation).
CTDSPL2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CTDSPL2	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
CTDSPL2	hdpi__HIP2	UBE2K (directAnnotation).
CTDSPL2	hdpi__TIMELESS	TIMELESS (directAnnotation).
CTDSPL2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CTDSPL2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
CTDSPL2	metacluster_191.5	SPDEF (inferredBy_Orthology).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."