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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CRISPLD1

Summary for CRISPLD1

Gene information	Gene symbol	CRISPLD1
	Ensembl ID	ENSG00000121005
	Entrez ID	83690
	Gene name	cysteine rich secretory protein LCCL domain containing 1
	Synonyms	Cocoacrisp\|DKFZp762F133\|LCRISP1
	Gene type	protein_coding
	UniProtAcc	Q9H336

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Dataset with differentially expressed gene: CRISPLD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-3.52462	3.41e-08

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Expression of CRISPLD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CRISPLD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CRISPLD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CRISPLD1	hsa-miR-4722-5p	87.5963	NM_031461
CRISPLD1	hsa-miR-3942-5p	86.6186	NM_031461
CRISPLD1	hsa-miR-876-5p	86.5215	NM_031461
CRISPLD1	hsa-miR-3167	86.5215	NM_031461
CRISPLD1	hsa-miR-1587	86.4389	NM_031461
CRISPLD1	hsa-miR-5693	86.4075	NM_031461
CRISPLD1	hsa-miR-376a-5p	86.2868	NM_031461
CRISPLD1	hsa-miR-6512-5p	86.2497	NM_031461
CRISPLD1	hsa-miR-519a-3p	86.0185	NM_031461
CRISPLD1	hsa-miR-519c-3p	86.0185	NM_031461
CRISPLD1	hsa-miR-519b-3p	86.0185	NM_031461
CRISPLD1	hsa-miR-4766-3p	85.9904	NM_031461
CRISPLD1	hsa-miR-4656	85.3811	NM_031461
CRISPLD1	hsa-miR-510-3p	84.5528	NM_031461
CRISPLD1	hsa-miR-101-3p	84.3664	NM_031461
CRISPLD1	hsa-miR-3620-5p	84.1094	NM_031461
CRISPLD1	hsa-let-7a-2-3p	83.0352	NM_031461
CRISPLD1	hsa-let-7g-3p	83.0352	NM_031461
CRISPLD1	hsa-miR-877-3p	82.6018	NM_031461
CRISPLD1	hsa-miR-130b-5p	82.5859	NM_031461
CRISPLD1	hsa-let-7f-2-3p	81.8123	NM_031461
CRISPLD1	hsa-miR-1185-2-3p	81.8123	NM_031461
CRISPLD1	hsa-miR-4789-5p	81.8123	NM_031461
CRISPLD1	hsa-miR-1185-1-3p	81.8123	NM_031461
CRISPLD1	hsa-miR-5003-3p	80.8624	NM_031461
CRISPLD1	hsa-miR-548t-3p	80.7423	NM_031461
CRISPLD1	hsa-miR-548aa	80.7423	NM_031461
CRISPLD1	hsa-miR-548ap-3p	80.7423	NM_031461
CRISPLD1	hsa-miR-1236-3p	80.7417	NM_031461
CRISPLD1	hsa-miR-499a-3p	80.521	NM_031461
CRISPLD1	hsa-miR-499b-3p	80.521	NM_031461
CRISPLD1	hsa-miR-3664-5p	80.2607	NM_031461

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Motifs and transcription factors (TFs) regulating CRISPLD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."