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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CRIM1

Summary for CRIM1

Gene information	Gene symbol	CRIM1
	Ensembl ID	ENSG00000277354
	Entrez ID	51232
	Gene name	cysteine rich transmembrane BMP regulator 1
	Synonyms	S52
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CRIM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.282557	6.10e-05
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.32464	6.33e-14

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Expression of CRIM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CRIM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CRIM1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CRIM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CRIM1	hsa-miR-9983-3p	82.2232	NM_016441
CRIM1	hsa-miR-10393-3p	82.1525	NM_016441
CRIM1	hsa-miR-6801-5p	82.1525	NM_016441
CRIM1	hsa-miR-600	81.8992	NM_016441
CRIM1	hsa-miR-4482-3p	81.8776	NM_016441
CRIM1	hsa-miR-561-3p	81.5013	NM_016441
CRIM1	hsa-miR-4474-3p	81.4322	NM_016441
CRIM1	hsa-miR-629-3p	81.2939	NM_016441
CRIM1	hsa-miR-3074-5p	81.1688	NM_016441
CRIM1	hsa-miR-5006-5p	81.0369	NM_016441
CRIM1	hsa-miR-4719	80.7536	NM_016441
CRIM1	hsa-miR-544a	80.7124	NM_016441
CRIM1	hsa-miR-302e	80.6719	NM_016441
CRIM1	hsa-miR-3674	80.6305	NM_016441
CRIM1	hsa-miR-935	80.5564	NM_016441
CRIM1	hsa-miR-3138	80.5167	NM_016441

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Motifs and transcription factors (TFs) regulating CRIM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CRIM1	transfac_pro__M05993	ZNF711 (directAnnotation).
CRIM1	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
CRIM1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
CRIM1	metacluster_22.25	NFE2L2 (directAnnotation).
CRIM1	transfac_pro__M06117	ZNF23 (directAnnotation).
CRIM1	jaspar__MA0079.5	SP1 (directAnnotation).
CRIM1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
CRIM1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
CRIM1	transfac_pro__M01253	CNOT3 (directAnnotation).
CRIM1	hdpi__NFIX	NFIX (directAnnotation).
CRIM1	transfac_pro__M04817	ZBTB33 (directAnnotation).
CRIM1	transfac_pro__M05712	ZNF134 (directAnnotation).
CRIM1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."