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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CREBZF

Summary for CREBZF

Gene information	Gene symbol	CREBZF
	Ensembl ID	ENSG00000137504
	Entrez ID	58487
	Gene name	CREB/ATF bZIP transcription factor
	Synonyms	ZF
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CREBZF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.378777	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.281989	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.278658	3.90e-09

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Expression of CREBZF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CREBZF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CREBZF	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CREBZF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CREBZF	hsa-miR-374c-5p	90.7943	NM_001039618
CREBZF	hsa-miR-4698	90.7058	NM_001039618
CREBZF	hsa-miR-1277-5p	90.5969	NM_001039618
CREBZF	hsa-miR-4495	90.5077	NM_001039618
CREBZF	hsa-miR-499a-5p	89.8977	NM_001039618
CREBZF	hsa-miR-7844-5p	89.8897	NM_001039618
CREBZF	hsa-miR-186-5p	89.7568	NM_001039618
CREBZF	hsa-miR-519d-5p	89.6983	NM_001039618
CREBZF	hsa-miR-7155-3p	89.3938	NM_001039618
CREBZF	hsa-miR-3136-3p	89.3938	NM_001039618
CREBZF	hsa-miR-8485	89.272	NM_001039618
CREBZF	hsa-miR-3671	89.103	NM_001039618
CREBZF	hsa-miR-4275	89.0117	NM_001039618
CREBZF	hsa-miR-548l	88.744	NM_001039618
CREBZF	hsa-miR-335-3p	88.5301	NM_001039618
CREBZF	hsa-miR-4666a-3p	88.2088	NM_001039618
CREBZF	hsa-miR-3145-5p	87.8914	NM_001039618
CREBZF	hsa-miR-6131	87.7021	NM_001039618
CREBZF	hsa-miR-4282	87.5581	NM_001039618
CREBZF	hsa-miR-208b-3p	87.0844	NM_001039618
CREBZF	hsa-miR-208a-3p	87.0844	NM_001039618
CREBZF	hsa-miR-3919	86.7865	NM_001039618
CREBZF	hsa-miR-875-3p	86.7368	NM_001039618
CREBZF	hsa-miR-6512-5p	86.5454	NM_001039618
CREBZF	hsa-miR-641	86.5217	NM_001039618
CREBZF	hsa-miR-4789-3p	86.5072	NM_001039618
CREBZF	hsa-miR-7152-3p	85.8147	NM_001039618
CREBZF	hsa-miR-6083	85.7107	NM_001039618
CREBZF	hsa-miR-375-3p	85.6103	NM_001039618
CREBZF	hsa-miR-3143	85.5065	NM_001039618
CREBZF	hsa-miR-5688	85.5043	NM_001039618
CREBZF	hsa-miR-300	85.3407	NM_001039618
CREBZF	hsa-miR-381-3p	85.3407	NM_001039618
CREBZF	hsa-miR-136-5p	85.3216	NM_001039618
CREBZF	hsa-miR-4257	84.6491	NM_001039618
CREBZF	hsa-miR-659-3p	84.589	NM_001039618
CREBZF	hsa-miR-633	84.564	NM_001039618
CREBZF	hsa-miR-466	84.4291	NM_001039618
CREBZF	hsa-miR-12124	84.3174	NM_001039618
CREBZF	hsa-miR-922	84.0373	NM_001039618
CREBZF	hsa-miR-3182	83.9689	NM_001039618
CREBZF	hsa-miR-4729	83.2103	NM_001039618
CREBZF	hsa-miR-4301	83.0561	NM_001039618
CREBZF	hsa-miR-6715b-5p	82.8375	NM_001039618
CREBZF	hsa-miR-4269	82.8375	NM_001039618
CREBZF	hsa-miR-616-5p	82.8307	NM_001039618
CREBZF	hsa-miR-135a-5p	82.5089	NM_001039618
CREBZF	hsa-miR-135b-5p	82.5089	NM_001039618
CREBZF	hsa-miR-3617-5p	82.4716	NM_001039618
CREBZF	hsa-miR-495-3p	82.4105	NM_001039618

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Motifs and transcription factors (TFs) regulating CREBZF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CREBZF	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CREBZF	transfac_pro__M07448	ZBED1 (directAnnotation).
CREBZF	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CREBZF	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CREBZF	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CREBZF	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CREBZF	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
CREBZF	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
CREBZF	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CREBZF	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CREBZF	jaspar__MA1122.1	TFDP1 (directAnnotation).
CREBZF	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
CREBZF	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CREBZF	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
CREBZF	hdpi__TP73	TP73 (directAnnotation).
CREBZF	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
CREBZF	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
CREBZF	transfac_pro__M05706	ZNF20 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."