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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CREB1

Summary for CREB1

Gene information	Gene symbol	CREB1
	Ensembl ID	ENSG00000118260
	Entrez ID	1385
	Gene name	cAMP responsive element binding protein 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P16220

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Dataset with differentially expressed gene: CREB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.277045	0.00e+00

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Expression of CREB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CREB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CREB1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CREB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CREB1	hsa-miR-548ap-3p	93.9638	NM_004379
CREB1	hsa-miR-4692	93.7617	NM_004379
CREB1	hsa-miR-889-3p	93.7408	NM_001320793
CREB1	hsa-miR-520d-5p	93.727	NM_004379
CREB1	hsa-miR-524-5p	93.727	NM_004379
CREB1	hsa-miR-548t-5p	93.7178	NM_004379
CREB1	hsa-miR-548az-5p	93.7178	NM_004379
CREB1	hsa-miR-616-5p	93.6824	NM_004379
CREB1	hsa-miR-371b-5p	93.6824	NM_004379
CREB1	hsa-miR-373-5p	93.6824	NM_004379
CREB1	hsa-miR-2113	93.3394	NM_004379
CREB1	hsa-miR-4465	93.2744	NM_004379
CREB1	hsa-miR-338-5p	93.1067	NM_004379
CREB1	hsa-miR-1238-5p	92.7847	NM_001320793
CREB1	hsa-miR-4758-5p	92.7847	NM_001320793
CREB1	hsa-miR-9985	92.5618	NM_004379
CREB1	hsa-miR-27a-3p	92.5618	NM_004379
CREB1	hsa-miR-27b-3p	92.5618	NM_004379
CREB1	hsa-miR-182-5p	92.5543	NM_004379
CREB1	hsa-miR-10a-5p	92.4641	NM_004379
CREB1	hsa-miR-10b-5p	92.4641	NM_004379
CREB1	hsa-miR-4803	92.3661	NM_134442
CREB1	hsa-miR-1252-3p	92.1628	NM_134442
CREB1	hsa-miR-205-3p	92.1029	NM_004379
CREB1	hsa-miR-4514	91.4438	NM_004379
CREB1	hsa-miR-944	91.0563	NM_001320793
CREB1	hsa-miR-5692a	90.9979	NM_134442
CREB1	hsa-miR-1295b-5p	90.8931	NM_134442
CREB1	hsa-miR-498-5p	90.8554	NM_004379
CREB1	hsa-miR-1200	90.7006	NM_004379
CREB1	hsa-miR-548e-5p	90.6804	NM_134442
CREB1	hsa-miR-493-3p	90.6301	NM_001320793
CREB1	hsa-miR-1912-3p	90.5985	NM_134442
CREB1	hsa-miR-548ah-3p	90.4094	NM_134442
CREB1	hsa-miR-548am-3p	90.4094	NM_134442
CREB1	hsa-miR-3688-3p	90.3806	NM_134442
CREB1	hsa-miR-4775	90.2518	NM_004379
CREB1	hsa-miR-519b-3p	90.1979	NM_004379
CREB1	hsa-miR-519c-3p	90.1979	NM_004379
CREB1	hsa-miR-519a-3p	90.1979	NM_004379
CREB1	hsa-miR-4742-5p	90.1806	NM_004379
CREB1	hsa-miR-128-3p	90.0418	NM_004379
CREB1	hsa-miR-20b-5p	90.0029	NM_004379
CREB1	hsa-miR-519d-3p	90.0029	NM_004379
CREB1	hsa-miR-93-5p	90.0029	NM_004379
CREB1	hsa-miR-17-5p	90.0029	NM_004379
CREB1	hsa-miR-526b-3p	89.9858	NM_004379
CREB1	hsa-miR-106b-5p	89.9858	NM_004379
CREB1	hsa-miR-106a-5p	89.9858	NM_004379
CREB1	hsa-miR-20a-5p	89.9858	NM_004379

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Motifs and transcription factors (TFs) regulating CREB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CREB1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CREB1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CREB1	transfac_pro__M07397	ZNF148 (directAnnotation).
CREB1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CREB1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CREB1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CREB1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CREB1	metacluster_7.13	ZFX (directAnnotation).
CREB1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CREB1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CREB1	transfac_pro__M01175	ZBTB7B (directAnnotation).
CREB1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CREB1	tfdimers__MD00151	CHURC1 (directAnnotation).
CREB1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CREB1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CREB1	transfac_pro__M01303	SP1 (directAnnotation).
CREB1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CREB1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CREB1	transfac_pro__M02090	E2F4 (directAnnotation).
CREB1	transfac_pro__M01714	KLF15 (directAnnotation).
CREB1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CREB1	jaspar__MA1122.1	TFDP1 (directAnnotation).
CREB1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CREB1	transfac_pro__M02089	E2F3 (directAnnotation).
CREB1	metacluster_3.14	WT1; WT1 (directAnnotation).
CREB1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CREB1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CREB1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CREB1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CREB1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CREB1	cisbp__M07938	E2F1 (directAnnotation).
CREB1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
CREB1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CREB1	transfac_pro__M07436	WT1 (directAnnotation).
CREB1	transfac_pro__M02281	SP1 (directAnnotation).
CREB1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CREB1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CREB1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
CREB1	transfac_pro__M02898	SMAD3 (directAnnotation).
CREB1	transfac_public__M00491	PATZ1 (directAnnotation).
CREB1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CREB1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CREB1	"Adenosine phosphate"	DB00131	small molecule
CREB1	"Naloxone"	DB01183	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."