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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CPSF6

Summary for CPSF6

Gene information	Gene symbol	CPSF6
	Ensembl ID	ENSG00000111605
	Entrez ID	11052
	Gene name	cleavage and polyadenylation specific factor 6
	Synonyms	CFIM\|CFIM68\|CFIM72\|HPBRII-4\|HPBRII-7
	Gene type	protein_coding
	UniProtAcc	Q16630

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Dataset with differentially expressed gene: CPSF6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.25717	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.270556	8.52e-08
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.397453	0.00e+00

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Expression of CPSF6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CPSF6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CPSF6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CPSF6	hsa-miR-7153-3p	90.5403	NM_001300947
CPSF6	hsa-miR-507	90.3201	NM_007007
CPSF6	hsa-miR-520h	89.8461	NM_007007
CPSF6	hsa-miR-520g-3p	89.8461	NM_007007
CPSF6	hsa-miR-2681-5p	89.4647	NM_001300947
CPSF6	hsa-miR-4319	89.2783	NM_001300947
CPSF6	hsa-miR-6806-3p	89.1623	NM_007007
CPSF6	hsa-miR-3928-5p	89.1623	NM_007007
CPSF6	hsa-miR-3941	88.7696	NM_001300947
CPSF6	hsa-miR-3679-3p	88.5691	NM_007007
CPSF6	hsa-miR-600	88.3743	NM_007007
CPSF6	hsa-miR-6757-3p	88.366	NM_007007
CPSF6	hsa-miR-4457	88.3509	NM_001300947
CPSF6	hsa-miR-4327	88.3034	NM_001300947
CPSF6	hsa-miR-1277-5p	88.0819	NM_007007
CPSF6	hsa-miR-548aj-3p	87.8411	NM_007007
CPSF6	hsa-miR-548x-3p	87.8411	NM_007007
CPSF6	hsa-miR-190b-3p	87.7997	NM_001300947
CPSF6	hsa-miR-6885-3p	87.6354	NM_001300947
CPSF6	hsa-miR-885-5p	87.5001	NM_007007
CPSF6	hsa-miR-9898	87.4624	NM_001300947
CPSF6	hsa-miR-590-3p	87.4032	NM_001300947
CPSF6	hsa-miR-4789-3p	87.19	NM_007007
CPSF6	hsa-miR-557	86.9945	NM_007007
CPSF6	hsa-miR-4503	86.6657	NM_007007
CPSF6	hsa-miR-1266-3p	86.6388	NM_007007
CPSF6	hsa-miR-4517	86.5453	NM_007007
CPSF6	hsa-miR-1283	86.473	NM_001300947
CPSF6	hsa-miR-125a-5p	86.3578	NM_001300947
CPSF6	hsa-miR-125b-5p	86.3578	NM_001300947
CPSF6	hsa-miR-12133	86.0411	NM_001300947
CPSF6	hsa-miR-187-5p	85.9237	NM_001300947
CPSF6	hsa-miR-4521	85.828	NM_001300947
CPSF6	hsa-miR-3923	85.7616	NM_007007
CPSF6	hsa-miR-374c-5p	85.7553	NM_007007
CPSF6	hsa-miR-655-3p	85.7553	NM_007007
CPSF6	hsa-miR-410-3p	85.7249	NM_007007
CPSF6	hsa-miR-628-3p	85.5713	NM_007007
CPSF6	hsa-miR-3646	85.4888	NM_007007
CPSF6	hsa-miR-125b-2-3p	85.3703	NM_001300947
CPSF6	hsa-miR-548t-3p	85.3049	NM_007007
CPSF6	hsa-miR-548ap-3p	85.3049	NM_007007
CPSF6	hsa-miR-548aa	85.3049	NM_007007
CPSF6	hsa-miR-802	85.1853	NM_007007
CPSF6	hsa-miR-5680	85.185	NM_007007
CPSF6	hsa-miR-2054	84.9245	NM_007007
CPSF6	hsa-miR-513b-5p	84.8455	NM_001300947
CPSF6	hsa-miR-548am-3p	84.7749	NM_007007
CPSF6	hsa-miR-548aq-3p	84.7749	NM_007007
CPSF6	hsa-miR-548j-3p	84.7749	NM_007007

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Motifs and transcription factors (TFs) regulating CPSF6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CPSF6	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CPSF6	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CPSF6	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
CPSF6	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CPSF6	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CPSF6	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
CPSF6	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
CPSF6	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CPSF6	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CPSF6	metacluster_3.14	WT1; WT1 (directAnnotation).
CPSF6	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CPSF6	cisbp__M07938	E2F1 (directAnnotation).
CPSF6	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CPSF6	transfac_pro__M04826	EP300 (directAnnotation).
CPSF6	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CPSF6	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CPSF6	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CPSF6	hdpi__FLI1	FLI1 (directAnnotation).
CPSF6	hdpi__ETV4	ETV4 (directAnnotation).
CPSF6	jaspar__MA1933.1	SREBF2 (directAnnotation).
CPSF6	hdpi__TP73	TP73 (directAnnotation).
CPSF6	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CPSF6	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CPSF6	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
CPSF6	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CPSF6	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
CPSF6	hdpi__ELF2	ELF2 (directAnnotation).
CPSF6	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CPSF6	transfac_pro__M04862	NRF1 (directAnnotation).
CPSF6	metacluster_81.7	CREB1 (directAnnotation).
CPSF6	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CPSF6	transfac_pro__M00492	STAT1 (directAnnotation).
CPSF6	swissregulon__hs__ELK1	ELK1 (directAnnotation).
CPSF6	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CPSF6	metacluster_183.4	ETS1 (inferredBy_Orthology).
CPSF6	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CPSF6	hdpi__NRL	NRL (directAnnotation).
CPSF6	transfac_pro__M07310	SP5 (directAnnotation).
CPSF6	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
CPSF6	cisbp__M00968	MTF2 (directAnnotation).
CPSF6	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CPSF6	transfac_pro__M04817	ZBTB33 (directAnnotation).
CPSF6	tfdimers__MD00483	ZBTB14 (directAnnotation).
CPSF6	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CPSF6	transfac_pro__M02089	E2F3 (directAnnotation).
CPSF6	transfac_pro__M07317	CTBP1 (directAnnotation).
CPSF6	transfac_pro__M12697	ZNF142 (directAnnotation).
CPSF6	transfac_pro__M00716	ZBTB14 (directAnnotation).
CPSF6	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CPSF6	transfac_pro__M03806	ZBTB7C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."