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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CPD

Summary for CPD

Gene information	Gene symbol	CPD
	Ensembl ID	ENSG00000108582
	Entrez ID	1362
	Gene name	carboxypeptidase D
	Synonyms	GP180
	Gene type	protein_coding
	UniProtAcc	O75976

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Dataset with differentially expressed gene: CPD

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.723818	6.26e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.632364	1.16e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.561494	1.23e-12
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.964316	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.72265	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.362705	2.38e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.479275	7.82e-42
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.59013	1.16e-36
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.532027	4.20e-45

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Expression of CPD in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CPD

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CPD

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CPD	hsa-miR-548o-3p	87.0007	NM_001199775
CPD	hsa-miR-6507-3p	86.9173	NM_001199775
CPD	hsa-miR-1252-5p	86.873	NM_001199775
CPD	hsa-let-7f-2-3p	86.3233	NM_001199775
CPD	hsa-miR-1185-2-3p	86.3233	NM_001199775
CPD	hsa-miR-1185-1-3p	86.3233	NM_001199775
CPD	hsa-miR-33a-3p	86.2708	NM_001199775
CPD	hsa-miR-548c-3p	86.1593	NM_001199775
CPD	hsa-miR-195-5p	86.0729	NM_001199775
CPD	hsa-miR-6838-5p	86.0729	NM_001199775
CPD	hsa-miR-16-5p	86.0729	NM_001199775
CPD	hsa-miR-9902	86.0561	NM_001199775
CPD	hsa-miR-378d	85.6931	NM_001199775
CPD	hsa-miR-422a	85.6931	NM_001199775
CPD	hsa-miR-378f	85.6931	NM_001199775
CPD	hsa-miR-378i	85.6931	NM_001199775
CPD	hsa-miR-378a-3p	85.6931	NM_001199775
CPD	hsa-miR-378h	85.6931	NM_001199775
CPD	hsa-miR-378b	85.6931	NM_001199775
CPD	hsa-miR-378e	85.6931	NM_001199775
CPD	hsa-miR-378c	85.6931	NM_001199775
CPD	hsa-miR-5010-3p	85.6863	NM_001199775
CPD	hsa-miR-3691-3p	85.5901	NM_001199775
CPD	hsa-miR-4770	85.5429	NM_001199775
CPD	hsa-miR-143-3p	85.5429	NM_001199775
CPD	hsa-miR-424-5p	85.3664	NM_001199775
CPD	hsa-miR-766-3p	84.9458	NM_001199775
CPD	hsa-miR-6088	84.7087	NM_001199775
CPD	hsa-miR-6796-3p	84.3683	NM_001199775
CPD	hsa-miR-1180-3p	84.3073	NM_001199775
CPD	hsa-miR-95-5p	83.8965	NM_001199775
CPD	hsa-miR-3148	83.8932	NM_001199775
CPD	hsa-miR-548aj-3p	83.6077	NM_001199775
CPD	hsa-miR-548x-3p	83.6077	NM_001199775
CPD	hsa-miR-6854-5p	82.763	NM_001199775
CPD	hsa-miR-3065-3p	82.3649	NM_001199775
CPD	hsa-miR-4477b	82.292	NM_001199775
CPD	hsa-miR-3202	82.2642	NM_001199775
CPD	hsa-miR-4320	81.6967	NM_001199775
CPD	hsa-miR-4694-3p	81.6399	NM_001199775
CPD	hsa-miR-548e-3p	81.6289	NM_001199775
CPD	hsa-miR-2467-5p	81.6077	NM_001199775
CPD	hsa-miR-409-3p	81.4793	NM_001199775
CPD	hsa-miR-26a-5p	80.5601	NM_001199775
CPD	hsa-miR-26b-5p	80.5601	NM_001199775
CPD	hsa-miR-605-3p	80.5404	NM_001199775
CPD	hsa-miR-548d-3p	80.5239	NM_001199775
CPD	hsa-miR-670-3p	80.4542	NM_001199775
CPD	hsa-miR-6728-3p	80.1787	NM_001199775

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Motifs and transcription factors (TFs) regulating CPD

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CPD	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CPD	hdpi__HIP2	UBE2K (directAnnotation).
CPD	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CPD	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CPD	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CPD	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CPD	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CPD	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CPD	metacluster_198.3	ZFP64 (directAnnotation).
CPD	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CPD	metacluster_175.1	ZNF283 (directAnnotation).
CPD	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CPD	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CPD	transfac_pro__M03806	ZBTB7C (directAnnotation).
CPD	jaspar__MA1721.1	ZNF93 (directAnnotation).
CPD	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CPD	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CPD	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
CPD	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CPD	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
CPD	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CPD	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CPD	tfdimers__MD00364	WT1 (directAnnotation).
CPD	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CPD	transfac_pro__M01973	PLAG1 (directAnnotation).
CPD	metacluster_143.13	ZBTB7A (directAnnotation).
CPD	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
CPD	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
CPD	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CPD	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
CPD	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
CPD	metacluster_134.7	FOXD2; FOXG1; FOXI1; FOXJ2; FOXJ2; FOXJ3; FOXJ3; FOXK1; FOXK1; FOXK2; FOXO4; FOXO6; FOXP2 (directAnnotation). FOXC1; FOXO1; FOXO6 (inferredBy_Orthology).
CPD	metacluster_22.37	BACH1 (directAnnotation).
CPD	transfac_pro__M05791	ZNF517 (directAnnotation).
CPD	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
CPD	metacluster_127.2	FOXA1; FOXA2; FOXA3; FOXC1; FOXC1; FOXC2; FOXD1; FOXD1; FOXF2; FOXF2; FOXJ1; FOXK2; FOXK2; FOXO6; FOXP1; FOXP1; FOXP1; FOXP1 (directAnnotation). FOXD2; FOXF1; FOXL3; FOXO1; FOXO3 (inferredBy_Orthology).
CPD	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
CPD	transfac_pro__M05991	ZFP64 (directAnnotation).
CPD	transfac_pro__M06742	ZNF304 (directAnnotation).
CPD	transfac_pro__M06071	ZNF814 (directAnnotation).
CPD	transfac_pro__M05995	ZNF180 (directAnnotation).
CPD	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
CPD	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CPD	metacluster_26.3	ZNF232 (directAnnotation).
CPD	metacluster_80.6	ZIC4 (directAnnotation).
CPD	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
CPD	transfac_pro__M05699	ZNF816 (directAnnotation).
CPD	tfdimers__MD00585	EBF1; STAT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CPD	"Guanidinoethylmercaptosuccinic acid"	DB04489	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."