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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: COL4A1

Summary for COL4A1

Gene informationGene symbol

COL4A1

Ensembl ID

ENSG00000187498

Entrez ID

1282

Gene namecollagen type IV alpha 1 chain
SynonymsNA
Gene typeprotein_coding
UniProtAcc

P02462


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Dataset with differentially expressed gene: COL4A1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells0.7444711.77e-03

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.4178970.00e+00

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Expression of COL4A1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to COL4A1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating COL4A1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
COL4A1hsa-miR-520d-5p89.3565NM_001845
COL4A1hsa-miR-568889.2505NM_001845
COL4A1hsa-miR-1245b-5p88.8118NM_001845
COL4A1hsa-miR-314288.8118NM_001845
COL4A1hsa-miR-556-3p88.7463NM_001845
COL4A1hsa-miR-971888.4295NM_001845
COL4A1hsa-let-7f-5p88.3947NM_001845
COL4A1hsa-let-7g-5p88.3947NM_001845
COL4A1hsa-let-7e-5p88.3947NM_001845
COL4A1hsa-let-7c-5p88.3947NM_001845
COL4A1hsa-miR-98-5p88.3947NM_001845
COL4A1hsa-let-7b-5p88.3947NM_001845
COL4A1hsa-let-7a-5p88.3947NM_001845
COL4A1hsa-let-7i-5p88.3947NM_001845
COL4A1hsa-miR-7-1-3p88.2475NM_001845
COL4A1hsa-miR-7-2-3p88.2475NM_001845
COL4A1hsa-let-7d-5p88.1625NM_001845
COL4A1hsa-miR-445888.1625NM_001845
COL4A1hsa-miR-202-3p88.1625NM_001845
COL4A1hsa-miR-495-3p88.1286NM_001845
COL4A1hsa-miR-998687.267NM_001845
COL4A1hsa-miR-129487.267NM_001845
COL4A1hsa-miR-3619-3p86.6989NM_001845
COL4A1hsa-miR-5591-3p86.6165NM_001303110
COL4A1hsa-miR-6730-5p86.5886NM_001303110
COL4A1hsa-miR-548aj-3p85.5054NM_001845
COL4A1hsa-miR-548x-3p85.5054NM_001845
COL4A1hsa-miR-4520-3p85.3514NM_001845
COL4A1hsa-miR-205-5p84.9632NM_001303110
COL4A1hsa-miR-628-5p84.7995NM_001845
COL4A1hsa-miR-369-3p84.7775NM_001845
COL4A1hsa-miR-548ah-3p84.6713NM_001845
COL4A1hsa-miR-548am-3p84.6713NM_001845
COL4A1hsa-miR-548aq-3p84.6713NM_001845
COL4A1hsa-miR-548j-3p84.6713NM_001845
COL4A1hsa-miR-548ae-3p84.6713NM_001845
COL4A1hsa-miR-612684.1552NM_001303110
COL4A1hsa-miR-63783.9298NM_001845
COL4A1hsa-miR-767-5p83.5939NM_001845
COL4A1hsa-miR-371483.5815NM_001845
COL4A1hsa-miR-391083.5815NM_001845
COL4A1hsa-miR-605-3p83.0005NM_001303110
COL4A1hsa-miR-545-3p82.8256NM_001845
COL4A1hsa-miR-509482.6937NM_001845
COL4A1hsa-miR-4789-3p82.0636NM_001845
COL4A1hsa-miR-6830-3p81.4989NM_001845
COL4A1hsa-miR-428681.0713NM_001303110
COL4A1hsa-miR-335-3p80.9842NM_001845
COL4A1hsa-miR-4776-5p80.5176NM_001845
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Motifs and transcription factors (TFs) regulating COL4A1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
COL4A1metacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
COL4A1dbtfbs__E2F8_representative_N1E2F8 (directAnnotation).
COL4A1metacluster_15.3E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
COL4A1taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_reprETV2; HES7 (directAnnotation).
COL4A1taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_reprERF; HES7 (directAnnotation).
COL4A1jaspar__MA1122.1TFDP1 (directAnnotation).
COL4A1transfac_pro__M04617ZBTB7A (directAnnotation).
COL4A1transfac_pro__M07387ZBTB7A (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."