DRMref Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Datasets with differential expression of this gene

leaf

Expression of this gene in the resistant group across all datasets and cell types

leaf

Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

leaf

Known drug resistance mechanisms of this gene (This gene does not contain this module)

leaf

MicroRNAs (miRNAs) regulating this gene

leaf

Motifs and transcription factors (TFs) regulating this gene

leaf

Acts as a transcription factor (This gene does not contain this module)

leaf

Acts as a drug target< (This gene does not contain this module)

Gene: CNOT4

Summary for CNOT4

Gene informationGene symbol

CNOT4

Ensembl ID

ENSG00000080802

Entrez ID

4850

Gene nameCCR4-NOT transcription complex subunit 4
SynonymsCLONE243|NOT4|NOT4H
Gene typeprotein_coding
UniProtAcc

O95628


Top

Dataset with differentially expressed gene: CNOT4

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.2875730.00e+00

Top

Expression of CNOT4 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

Top

Significant ligand-receptor pairs related to CNOT4

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CNOT4

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CNOT4hsa-miR-627-3p86.4767NM_001190850
CNOT4hsa-miR-5699-3p86.1458NM_001190850
CNOT4hsa-miR-570085.7792NM_001008225
CNOT4hsa-miR-338-5p85.7354NM_001008225
CNOT4hsa-miR-3162-5p85.7237NM_001190850
CNOT4hsa-miR-1304-5p85.3947NM_001008225
CNOT4hsa-miR-4743-3p84.8751NM_001190850
CNOT4hsa-miR-448484.4745NM_001008225
CNOT4hsa-miR-548an84.4745NM_001008225
CNOT4hsa-miR-477584.3062NM_001008225
CNOT4hsa-miR-430583.9951NM_001008225
CNOT4hsa-miR-3065-5p83.8217NM_001190850
CNOT4hsa-miR-442183.8079NM_001190850
CNOT4hsa-miR-548aw83.0585NM_001008225
CNOT4hsa-miR-990282.6055NM_001008225
CNOT4hsa-miR-4772-5p82.5997NM_001190850
CNOT4hsa-miR-545-5p81.8325NM_001008225
CNOT4hsa-miR-427981.4899NM_001190850
CNOT4hsa-miR-432081.3286NM_001190850
CNOT4hsa-miR-144-3p81.2343NM_001008225
CNOT4hsa-miR-629-3p81.0276NM_001190850
CNOT4hsa-miR-1250-3p80.867NM_001190850
CNOT4hsa-miR-26a-5p80.5362NM_001008225
CNOT4hsa-miR-26b-5p80.5362NM_001008225
CNOT4hsa-miR-4699-3p80.2108NM_001190850
Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CNOT4

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CNOT4metacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CNOT4dbtfbs__E2F8_representative_N1E2F8 (directAnnotation).
CNOT4transfac_pro__M04950EGR1 (directAnnotation).
CNOT4metacluster_34.4ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
CNOT4taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_reprERF; HES7 (directAnnotation).
CNOT4transfac_pro__M00652NRF1 (directAnnotation).
CNOT4hdpi__ETV4ETV4 (directAnnotation).
CNOT4transfac_pro__M04866HDAC2 (directAnnotation).
CNOT4metacluster_34.1ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
CNOT4swissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
CNOT4metacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CNOT4metacluster_34.3EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
Page: 1

Top

Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."