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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: CHD1

Summary for CHD1

Gene information	Gene symbol	CHD1
	Ensembl ID	ENSG00000153922
	Entrez ID	1105
	Gene name	chromodomain helicase DNA binding protein 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CHD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.293624	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.293307	2.04e-09
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.286515	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.269819	2.85e-13
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.329767	3.79e-11
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.395839	7.63e-08
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.532292	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.543275	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	-0.254892	2.27e-24
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.508219	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.320649	8.58e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.777605	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.589379	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.286519	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.326999	0.00e+00

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Expression of CHD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHD1	hsa-miR-5004-3p	83.3796	NM_001270
CHD1	hsa-miR-6849-3p	83.0997	NM_001270
CHD1	hsa-miR-8076	82.9829	NM_001270
CHD1	hsa-miR-4799-5p	82.8968	NM_001270
CHD1	hsa-miR-4477a	82.8296	NM_001270
CHD1	hsa-miR-3667-3p	82.6746	NM_001270
CHD1	hsa-miR-181d-5p	82.4202	NM_001270
CHD1	hsa-miR-181a-5p	82.4202	NM_001270
CHD1	hsa-miR-181c-5p	82.4202	NM_001270
CHD1	hsa-miR-181b-5p	82.4202	NM_001270
CHD1	hsa-miR-4666a-3p	82.3866	NM_001270
CHD1	hsa-miR-3182	81.9703	NM_001270
CHD1	hsa-miR-5093	81.5736	NM_001270
CHD1	hsa-let-7f-1-3p	81.0749	NM_001270
CHD1	hsa-let-7a-3p	81.0749	NM_001270
CHD1	hsa-let-7b-3p	81.0749	NM_001270
CHD1	hsa-miR-98-3p	81.0749	NM_001270
CHD1	hsa-miR-410-3p	81.0253	NM_001270
CHD1	hsa-miR-3613-3p	81.0103	NM_001270
CHD1	hsa-miR-4254	80.0754	NM_001270
CHD1	hsa-miR-3690	80.0754	NM_001270

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Motifs and transcription factors (TFs) regulating CHD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHD1	metacluster_7.13	ZFX (directAnnotation).
CHD1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CHD1	metacluster_151.2	ZNF23 (directAnnotation).
CHD1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CHD1	transfac_pro__M05479	ZNF580 (directAnnotation).
CHD1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CHD1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CHD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CHD1	metacluster_182.10	ZFX (directAnnotation).
CHD1	transfac_pro__M06071	ZNF814 (directAnnotation).
CHD1	jaspar__MA0748.2	YY2 (directAnnotation).
CHD1	transfac_pro__M05628	ZNF735 (directAnnotation).
CHD1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CHD1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CHD1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CHD1	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
CHD1	jaspar__MA0079.5	SP1 (directAnnotation).
CHD1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
CHD1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CHD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CHD1	transfac_pro__M07397	ZNF148 (directAnnotation).
CHD1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CHD1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CHD1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CHD1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CHD1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CHD1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CHD1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CHD1	transfac_pro__M01175	ZBTB7B (directAnnotation).
CHD1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CHD1	tfdimers__MD00151	CHURC1 (directAnnotation).
CHD1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CHD1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CHD1	transfac_pro__M01303	SP1 (directAnnotation).
CHD1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CHD1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CHD1	transfac_pro__M02090	E2F4 (directAnnotation).
CHD1	transfac_pro__M01714	KLF15 (directAnnotation).
CHD1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CHD1	jaspar__MA1122.1	TFDP1 (directAnnotation).
CHD1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CHD1	transfac_pro__M02089	E2F3 (directAnnotation).
CHD1	transfac_pro__M12604	ZNF444 (directAnnotation).
CHD1	metacluster_3.14	WT1; WT1 (directAnnotation).
CHD1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CHD1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CHD1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CHD1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CHD1	cisbp__M07938	E2F1 (directAnnotation).
CHD1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
CHD1	swissregulon__hs__CHD1	up	Malignant cells	GSE138267	NA
CHD1	swissregulon__hs__CHD1	up	CD4+ T cells	GSE169246_PacBlood	pre
CHD1	swissregulon__hs__CHD1	down	Malignant cells	GSE199333	post
CHD1	swissregulon__hs__CHD1	down	Malignant cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."