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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CDK17

Summary for CDK17

Gene information	Gene symbol	CDK17
	Ensembl ID	ENSG00000059758
	Entrez ID	5128
	Gene name	cyclin dependent kinase 17
	Synonyms	PCTAIRE2\|PCTK2
	Gene type	protein_coding
	UniProtAcc	Q00537

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Dataset with differentially expressed gene: CDK17

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.317628	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.368988	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.328706	1.15e-42
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.270367	8.00e-18
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.304468	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.300252	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.384556	4.20e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.330981	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.459369	0.00e+00

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Expression of CDK17 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDK17

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDK17

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDK17	hsa-miR-195-3p	90.1677	NM_001170464
CDK17	hsa-miR-338-5p	89.9317	NM_001170464
CDK17	hsa-miR-16-5p	89.3871	NM_002595
CDK17	hsa-miR-195-5p	89.3871	NM_002595
CDK17	hsa-miR-15a-5p	89.3871	NM_002595
CDK17	hsa-miR-15b-5p	89.3871	NM_002595
CDK17	hsa-miR-513a-3p	89.3164	NM_001170464
CDK17	hsa-miR-513c-3p	89.3164	NM_001170464
CDK17	hsa-miR-1257	89.1725	NM_001170464
CDK17	hsa-miR-1324	89.1237	NM_001170464
CDK17	hsa-miR-4708-5p	89.028	NM_001170464
CDK17	hsa-miR-223-3p	88.9851	NM_002595
CDK17	hsa-miR-548x-3p	88.7951	NM_001170464
CDK17	hsa-miR-548aj-3p	88.7951	NM_001170464
CDK17	hsa-miR-3662	88.2557	NM_002595
CDK17	hsa-miR-4524b-5p	88.1745	NM_002595
CDK17	hsa-miR-4524a-5p	88.1745	NM_002595
CDK17	hsa-miR-3606-3p	87.6981	NM_001170464
CDK17	hsa-miR-4784	87.0595	NM_002595
CDK17	hsa-miR-3150b-3p	87.0595	NM_002595
CDK17	hsa-miR-892c-3p	87.054	NM_001170464
CDK17	hsa-miR-4676-3p	87.054	NM_001170464
CDK17	hsa-miR-452-5p	87.054	NM_001170464
CDK17	hsa-miR-509-3p	86.9733	NM_002595
CDK17	hsa-miR-374b-3p	86.9553	NM_001170464
CDK17	hsa-miR-145-3p	86.5545	NM_001170464
CDK17	hsa-miR-548ae-3p	86.4146	NM_001170464
CDK17	hsa-miR-548am-3p	86.4146	NM_001170464
CDK17	hsa-miR-548j-3p	86.4146	NM_001170464
CDK17	hsa-miR-548ah-3p	86.4146	NM_001170464
CDK17	hsa-miR-548aq-3p	86.4146	NM_001170464
CDK17	hsa-miR-424-5p	86.38	NM_001170464
CDK17	hsa-miR-6838-5p	86.38	NM_001170464
CDK17	hsa-miR-497-5p	86.38	NM_001170464
CDK17	hsa-miR-3973	85.9786	NM_002595
CDK17	hsa-miR-6500-3p	85.9703	NM_001170464
CDK17	hsa-miR-3646	85.8742	NM_001170464
CDK17	hsa-miR-1244	85.8207	NM_001170464
CDK17	hsa-miR-23a-3p	85.7039	NM_002595
CDK17	hsa-miR-23b-3p	85.7039	NM_002595
CDK17	hsa-miR-23c	85.7039	NM_002595
CDK17	hsa-miR-607	85.5775	NM_002595
CDK17	hsa-miR-4490	85.3482	NM_001170464
CDK17	hsa-miR-3928-3p	84.3686	NM_002595
CDK17	hsa-miR-122b-3p	84.27	NM_001170464
CDK17	hsa-miR-513b-3p	84.0822	NM_002595
CDK17	hsa-miR-181a-5p	84.0035	NM_001170464
CDK17	hsa-miR-181b-5p	84.0035	NM_001170464
CDK17	hsa-miR-181d-5p	84.0035	NM_001170464
CDK17	hsa-miR-181c-5p	84.0035	NM_001170464

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Motifs and transcription factors (TFs) regulating CDK17

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDK17	jaspar__MA0748.2	YY2 (directAnnotation).
CDK17	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CDK17	cisbp__M00788	ZFY (inferredBy_Orthology).
CDK17	metacluster_7.13	ZFX (directAnnotation).
CDK17	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
CDK17	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CDK17	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CDK17	hdpi__HIP2	UBE2K (directAnnotation).
CDK17	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CDK17	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CDK17	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CDK17	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CDK17	transfac_pro__M02898	SMAD3 (directAnnotation).
CDK17	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CDK17	metacluster_191.5	SPDEF (inferredBy_Orthology).
CDK17	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CDK17	hdpi__TIMELESS	TIMELESS (directAnnotation).
CDK17	transfac_pro__M04893	TAF1 (directAnnotation).
CDK17	cisbp__M00249	WT1 (directAnnotation).
CDK17	transfac_pro__M00430	E2F1 (directAnnotation).
CDK17	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CDK17	hdpi__ZNF304	ZNF304 (directAnnotation).
CDK17	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
CDK17	transfac_pro__M00938	E2F1 (directAnnotation).
CDK17	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CDK17	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CDK17	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CDK17	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CDK17	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CDK17	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CDK17	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CDK17	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CDK17	transfac_pro__M01199	TRIM28 (directAnnotation).
CDK17	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CDK17	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CDK17	hdpi__ELF2	ELF2 (directAnnotation).
CDK17	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
CDK17	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CDK17	metacluster_32.25	ZNF287 (directAnnotation).
CDK17	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
CDK17	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
CDK17	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CDK17	transfac_pro__M06488	ZNF595 (directAnnotation).
CDK17	metacluster_198.3	ZFP64 (directAnnotation).
CDK17	cisbp__M00341	PAX6 (directAnnotation).
CDK17	cisbp__M00968	MTF2 (directAnnotation).
CDK17	transfac_pro__M00716	ZBTB14 (directAnnotation).
CDK17	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
CDK17	transfac_pro__M04916	TAF1 (directAnnotation).
CDK17	transfac_pro__M02089	E2F3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CDK17	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."