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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDK14

Summary for CDK14

Gene information	Gene symbol	CDK14
	Ensembl ID	ENSG00000058091
	Entrez ID	5218
	Gene name	cyclin dependent kinase 14
	Synonyms	PFTAIRE1\|PFTK1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CDK14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.96716	3.05e-30

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Expression of CDK14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDK14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CDK14	Epigenetic Alteration of DNA, RNA or Protein

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MicroRNAs (miRNA) regulating CDK14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDK14	hsa-miR-6755-3p	86.1593	NM_001287135
CDK14	hsa-miR-1202	85.9828	NM_001287135
CDK14	hsa-miR-3972	85.9828	NM_001287135
CDK14	hsa-miR-3160-5p	85.4111	NM_001287135
CDK14	hsa-miR-4499	85.008	NM_001287135
CDK14	hsa-miR-7161-5p	84.9712	NM_001287135
CDK14	hsa-miR-194-5p	84.8082	NM_001287135
CDK14	hsa-miR-7152-5p	84.5884	NM_001287135
CDK14	hsa-miR-548aa	84.5351	NM_001287135
CDK14	hsa-miR-548t-3p	84.5351	NM_001287135
CDK14	hsa-miR-548ap-3p	84.5351	NM_001287135
CDK14	hsa-miR-579-3p	83.1407	NM_001287135
CDK14	hsa-miR-216a-5p	82.9443	NM_001287135
CDK14	hsa-miR-548u	82.8604	NM_001287135
CDK14	hsa-miR-6754-5p	82.7752	NM_001287135
CDK14	hsa-miR-4270	82.7752	NM_001287135
CDK14	hsa-miR-511-5p	82.7736	NM_001287135
CDK14	hsa-miR-211-5p	82.5032	NM_001287135
CDK14	hsa-miR-204-5p	82.5032	NM_001287135
CDK14	hsa-miR-6875-3p	82.3621	NM_001287135
CDK14	hsa-miR-570-3p	82.1381	NM_001287135
CDK14	hsa-miR-580-3p	82.0256	NM_001287135
CDK14	hsa-miR-96-3p	81.7466	NM_001287135
CDK14	hsa-miR-6734-3p	81.456	NM_001287135
CDK14	hsa-miR-4530	81.2548	NM_001287135
CDK14	hsa-miR-6744-3p	81.2529	NM_001287135
CDK14	hsa-miR-4757-5p	81.2529	NM_001287135
CDK14	hsa-miR-3924	80.9176	NM_001287135
CDK14	hsa-miR-488-3p	80.7714	NM_001287135
CDK14	hsa-miR-597-5p	80.1394	NM_001287135

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Motifs and transcription factors (TFs) regulating CDK14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDK14	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CDK14	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CDK14	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CDK14	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CDK14	transfac_pro__M04617	ZBTB7A (directAnnotation).
CDK14	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CDK14	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CDK14	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CDK14	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CDK14	transfac_pro__M07387	ZBTB7A (directAnnotation).
CDK14	transfac_pro__M07436	WT1 (directAnnotation).
CDK14	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CDK14	transfac_pro__M00716	ZBTB14 (directAnnotation).
CDK14	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CDK14	hdpi__HIP2	UBE2K (directAnnotation).
CDK14	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CDK14	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CDK14	transfac_pro__M04893	TAF1 (directAnnotation).
CDK14	transfac_pro__M03876	ZBTB33 (directAnnotation).
CDK14	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CDK14	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CDK14	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CDK14	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CDK14	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."