Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD164

Summary for CD164

Gene information	Gene symbol	CD164
	Ensembl ID	ENSG00000135535
	Entrez ID	8763
	Gene name	CD164 molecule
	Synonyms	DFNA66\|MGC-24\|MUC-24
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: CD164

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.298844	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	pDCs	0.651047	2.93e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.30296	2.49e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.308058	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.438427	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.300713	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	1.15296	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.270779	1.10e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.308954	4.41e-41
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.394851	3.59e-24
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.967791	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.337893	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.494968	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.634521	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.409071	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.329175	0.00e+00

Top

Expression of CD164 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CD164

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CD164

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD164	hsa-let-7b-5p	88.2655	NM_001142401
CD164	hsa-let-7c-5p	88.2655	NM_001142401
CD164	hsa-let-7d-5p	88.1821	NM_001142401
CD164	hsa-miR-4458	88.1821	NM_001142401
CD164	hsa-miR-202-3p	88.1821	NM_001142401
CD164	hsa-miR-548k	87.3362	NM_001142403
CD164	hsa-miR-548av-5p	87.3362	NM_001142403
CD164	hsa-miR-8054	87.3362	NM_001142403
CD164	hsa-miR-19a-3p	86.5134	NM_001142403
CD164	hsa-miR-19b-3p	86.5134	NM_001142403
CD164	hsa-miR-576-5p	86.4575	NM_001142401
CD164	hsa-miR-501-5p	86.3942	NM_001142401
CD164	hsa-miR-4642	86.355	NM_001142401
CD164	hsa-miR-4782-5p	86.0363	NM_001142403
CD164	hsa-miR-5706	86.0363	NM_001142403
CD164	hsa-miR-651-3p	85.7038	NM_001142401
CD164	hsa-miR-6516-5p	85.6066	NM_001142403
CD164	hsa-miR-4715-3p	85.424	NM_001142403
CD164	hsa-miR-4786-3p	85.278	NM_001142403
CD164	hsa-miR-590-3p	85.2506	NM_001142401
CD164	hsa-miR-150-3p	84.8426	NM_001142403
CD164	hsa-miR-4668-5p	84.3594	NM_001142403
CD164	hsa-miR-4328	83.0865	NM_001142403
CD164	hsa-miR-603	83.0094	NM_001142403
CD164	hsa-miR-7843-3p	82.9741	NM_001142403
CD164	hsa-miR-8085	82.4459	NM_001142403
CD164	hsa-miR-6731-5p	82.4459	NM_001142403
CD164	hsa-miR-3674	82.4043	NM_001142403
CD164	hsa-miR-3689c	82.1971	NM_001142403
CD164	hsa-miR-30b-3p	82.1971	NM_001142403
CD164	hsa-miR-3689b-3p	82.1971	NM_001142403
CD164	hsa-miR-6779-5p	82.1971	NM_001142403
CD164	hsa-miR-3689a-3p	82.1971	NM_001142403
CD164	hsa-miR-1273h-5p	82.1971	NM_001142403
CD164	hsa-miR-1299	81.7092	NM_001142401
CD164	hsa-miR-6780a-5p	81.3234	NM_001142403
CD164	hsa-miR-3202	81.0867	NM_001142403
CD164	hsa-miR-146a-3p	80.2581	NM_001142401

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CD164

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD164	transfac_pro__M06213	ZNF267 (directAnnotation).
CD164	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
CD164	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
CD164	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CD164	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CD164	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
CD164	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CD164	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CD164	hdpi__TP73	TP73 (directAnnotation).
CD164	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CD164	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CD164	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CD164	transfac_pro__M04826	EP300 (directAnnotation).
CD164	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CD164	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
CD164	hdpi__FLI1	FLI1 (directAnnotation).
CD164	cisbp__M02645	ETS1 (directAnnotation).
CD164	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CD164	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CD164	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
CD164	hdpi__ETV4	ETV4 (directAnnotation).
CD164	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
CD164	transfac_pro__M00492	STAT1 (directAnnotation).
CD164	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CD164	transfac_pro__M01298	MECP2 (directAnnotation).
CD164	cisbp__M01752	USF2 (inferredBy_Orthology).
CD164	transfac_pro__M05440	NKX2-3 (directAnnotation).
CD164	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CD164	hocomoco__ZN490_HUMAN.H11MO.0.C	ZNF490 (directAnnotation).
CD164	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CD164	metacluster_122.17	IRF6 (directAnnotation).
CD164	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CD164	transfac_pro__M02898	SMAD3 (directAnnotation).
CD164	hdpi__TIMELESS	TIMELESS (directAnnotation).
CD164	transfac_pro__M04893	TAF1 (directAnnotation).
CD164	cisbp__M00249	WT1 (directAnnotation).
CD164	transfac_pro__M00430	E2F1 (directAnnotation).
CD164	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CD164	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CD164	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
CD164	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CD164	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CD164	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CD164	hdpi__ELF2	ELF2 (directAnnotation).
CD164	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CD164	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CD164	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CD164	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CD164	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CD164	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."