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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCNT1

Summary for CCNT1

Gene information	Gene symbol	CCNT1
	Ensembl ID	ENSG00000129315
	Entrez ID	904
	Gene name	cyclin T1
	Synonyms	CCNT\|CYCT1\|HIVE1
	Gene type	protein_coding
	UniProtAcc	O60563

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Dataset with differentially expressed gene: CCNT1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.365826	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.357698	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.585035	0.00e+00

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Expression of CCNT1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCNT1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCNT1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCNT1	hsa-miR-4723-3p	86.7357	NM_001240
CCNT1	hsa-miR-3183	86.7357	NM_001240
CCNT1	hsa-miR-9500	86.6079	NM_001277842
CCNT1	hsa-miR-1236-5p	86.1139	NM_001277842
CCNT1	hsa-miR-6511b-3p	85.7619	NM_001240
CCNT1	hsa-miR-6511a-3p	85.7619	NM_001240
CCNT1	hsa-miR-200c-5p	85.7052	NM_001240
CCNT1	hsa-miR-5196-5p	85.3267	NM_001277842
CCNT1	hsa-miR-4747-5p	85.3267	NM_001277842
CCNT1	hsa-miR-603	85.2939	NM_001240
CCNT1	hsa-miR-4288	84.7791	NM_001277842
CCNT1	hsa-miR-6780a-5p	84.085	NM_001277842
CCNT1	hsa-miR-7111-3p	82.8942	NM_001240
CCNT1	hsa-miR-607	82.8613	NM_001277842
CCNT1	hsa-miR-4729	80.8763	NM_001277842
CCNT1	hsa-miR-5007-3p	80.734	NM_001240
CCNT1	hsa-miR-6756-5p	80.3979	NM_001240
CCNT1	hsa-miR-6766-5p	80.3979	NM_001240
CCNT1	hsa-miR-6875-5p	80.2354	NM_001277842
CCNT1	hsa-miR-3126-5p	80.2354	NM_001277842

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Motifs and transcription factors (TFs) regulating CCNT1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCNT1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CCNT1	hdpi__TIMELESS	TIMELESS (directAnnotation).
CCNT1	transfac_pro__M00430	E2F1 (directAnnotation).
CCNT1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CCNT1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CCNT1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CCNT1	hdpi__ELF2	ELF2 (directAnnotation).
CCNT1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."