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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCND2

Summary for CCND2

Gene information	Gene symbol	CCND2
	Ensembl ID	ENSG00000118971
	Entrez ID	894
	Gene name	cyclin D2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P30279

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Dataset with differentially expressed gene: CCND2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	7.09105	8.83e-16
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.260511	1.23e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.271026	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.467465	2.10e-44
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.545813	2.05e-08
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.258591	5.96e-07
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.442244	3.10e-13
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	-0.39136	1.97e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.404097	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.28193	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.292006	5.34e-34
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.337608	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.314084	0.00e+00

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Expression of CCND2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCND2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CCND2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CCND2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCND2	hsa-miR-6761-5p	92.3426	NM_001759
CCND2	hsa-miR-4731-5p	92.2995	NM_001759
CCND2	hsa-miR-19a-3p	92.1806	NM_001759
CCND2	hsa-miR-19b-3p	92.1806	NM_001759
CCND2	hsa-miR-12119	91.9725	NM_001759
CCND2	hsa-miR-9986	91.2886	NM_001759
CCND2	hsa-miR-1294	91.2886	NM_001759
CCND2	hsa-miR-106a-3p	91.2545	NM_001759
CCND2	hsa-miR-3148	89.447	NM_001759
CCND2	hsa-miR-3163	88.8998	NM_001759
CCND2	hsa-miR-218-2-3p	88.8832	NM_001759
CCND2	hsa-miR-623	88.6461	NM_001759
CCND2	hsa-miR-1251-3p	88.5741	NM_001759
CCND2	hsa-miR-5701	88.1485	NM_001759
CCND2	hsa-miR-4644	88.1289	NM_001759
CCND2	hsa-miR-544b	87.6257	NM_001759
CCND2	hsa-miR-141-3p	87.3171	NM_001759
CCND2	hsa-miR-200a-3p	87.3171	NM_001759
CCND2	hsa-miR-4761-5p	87.0216	NM_001759
CCND2	hsa-miR-6792-5p	86.9287	NM_001759
CCND2	hsa-miR-545-5p	86.8926	NM_001759
CCND2	hsa-miR-5582-5p	86.6335	NM_001759
CCND2	hsa-miR-621	86.4144	NM_001759
CCND2	hsa-miR-33a-3p	86.0296	NM_001759
CCND2	hsa-miR-3156-5p	85.7836	NM_001759
CCND2	hsa-miR-656-3p	85.534	NM_001759
CCND2	hsa-miR-5690	85.516	NM_001759
CCND2	hsa-miR-4275	85.3788	NM_001759
CCND2	hsa-miR-3912-5p	84.9919	NM_001759
CCND2	hsa-miR-4724-5p	84.9807	NM_001759
CCND2	hsa-miR-6511a-5p	84.96	NM_001759
CCND2	hsa-miR-1910-3p	84.6584	NM_001759
CCND2	hsa-miR-216b-3p	84.5352	NM_001759
CCND2	hsa-miR-185-5p	84.505	NM_001759
CCND2	hsa-miR-3529-3p	84.2109	NM_001759
CCND2	hsa-miR-3617-3p	83.5663	NM_001759
CCND2	hsa-miR-6868-3p	82.8819	NM_001759
CCND2	hsa-miR-9851-3p	82.8423	NM_001759
CCND2	hsa-miR-593-5p	82.8423	NM_001759
CCND2	hsa-miR-1205	82.8334	NM_001759
CCND2	hsa-miR-10394-5p	82.8334	NM_001759
CCND2	hsa-miR-4316	82.6587	NM_001759
CCND2	hsa-miR-5692c	82.5361	NM_001759
CCND2	hsa-miR-5692b	82.5361	NM_001759
CCND2	hsa-miR-1297	82.422	NM_001759
CCND2	hsa-miR-8082	82.2484	NM_001759
CCND2	hsa-miR-676-5p	82.1606	NM_001759
CCND2	hsa-miR-3622a-5p	82.1579	NM_001759
CCND2	hsa-miR-4534	81.8211	NM_001759
CCND2	hsa-miR-4678	81.6997	NM_001759

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Motifs and transcription factors (TFs) regulating CCND2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCND2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CCND2	transfac_pro__M04617	ZBTB7A (directAnnotation).
CCND2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CCND2	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CCND2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CCND2	transfac_pro__M07387	ZBTB7A (directAnnotation).
CCND2	transfac_pro__M07436	WT1 (directAnnotation).
CCND2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CCND2	transfac_pro__M00716	ZBTB14 (directAnnotation).
CCND2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CCND2	hdpi__HIP2	UBE2K (directAnnotation).
CCND2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CCND2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CCND2	transfac_pro__M04893	TAF1 (directAnnotation).
CCND2	transfac_pro__M03876	ZBTB33 (directAnnotation).
CCND2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CCND2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CCND2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CCND2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CCND2	cisbp__M08198	ELF1 (directAnnotation).
CCND2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CCND2	hdpi__TP73	TP73 (directAnnotation).
CCND2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CCND2	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
CCND2	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CCND2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CCND2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CCND2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CCND2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
CCND2	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
CCND2	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CCND2	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
CCND2	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
CCND2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
CCND2	hocomoco__MXI1_MOUSE.H11MO.1.A	MXI1 (inferredBy_Orthology).
CCND2	transfac_pro__M06643	ZNF583 (directAnnotation).
CCND2	tfdimers__MD00567	IKZF2 (directAnnotation).
CCND2	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
CCND2	kznf__ZNF442_Imbeault2017_RP_RCADE	ZNF442 (directAnnotation).
CCND2	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
CCND2	transfac_pro__M01252	E2F6 (directAnnotation).
CCND2	jaspar__MA1125.1	ZNF384 (directAnnotation).
CCND2	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
CCND2	taipale_tf_pairs__HOXB2_SOX15_ACAAWRSNNNNYMATTA_CAP_repr	HOXB2; SOX15 (directAnnotation).
CCND2	metacluster_32.25	ZNF287 (directAnnotation).
CCND2	tfdimers__MD00225	NKX6-2; POU5F1 (directAnnotation).
CCND2	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
CCND2	hocomoco__BPTF_HUMAN.H11MO.0.D	BPTF (directAnnotation).
CCND2	hdpi__ENO1	ENO1 (directAnnotation).
CCND2	transfac_pro__M05768	ZNF544 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."