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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC6

Summary for CCDC6

Gene information	Gene symbol	CCDC6
	Ensembl ID	ENSG00000108091
	Entrez ID	8030
	Gene name	coiled-coil domain containing 6
	Synonyms	D10S170\|H4\|PTC\|TPC\|TST1
	Gene type	protein_coding
	UniProtAcc	Q16204

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Dataset with differentially expressed gene: CCDC6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.579429	1.68e-33

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Expression of CCDC6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC6	hsa-miR-4769-3p	89.3917	NM_005436
CCDC6	hsa-miR-6817-5p	89.3917	NM_005436
CCDC6	hsa-miR-10b-3p	89.1894	NM_005436
CCDC6	hsa-miR-26b-5p	88.9927	NM_005436
CCDC6	hsa-miR-26a-5p	88.9927	NM_005436
CCDC6	hsa-miR-524-5p	88.608	NM_005436
CCDC6	hsa-miR-142-3p	88.4619	NM_005436
CCDC6	hsa-miR-7843-3p	88.0898	NM_005436
CCDC6	hsa-miR-30e-5p	87.8226	NM_005436
CCDC6	hsa-miR-30d-5p	87.8226	NM_005436
CCDC6	hsa-miR-30c-5p	87.8226	NM_005436
CCDC6	hsa-miR-30a-5p	87.8226	NM_005436
CCDC6	hsa-miR-30b-5p	87.8226	NM_005436
CCDC6	hsa-miR-671-5p	87.4588	NM_005436
CCDC6	hsa-miR-4255	87.1731	NM_005436
CCDC6	hsa-miR-507	87.0026	NM_005436
CCDC6	hsa-miR-6854-5p	86.8841	NM_005436
CCDC6	hsa-miR-649	86.875	NM_005436
CCDC6	hsa-miR-6124	86.8689	NM_005436
CCDC6	hsa-miR-500a-3p	86.6465	NM_005436
CCDC6	hsa-miR-301b-3p	86.4379	NM_005436
CCDC6	hsa-miR-3666	86.4379	NM_005436
CCDC6	hsa-miR-301a-3p	86.4379	NM_005436
CCDC6	hsa-miR-4295	86.4379	NM_005436
CCDC6	hsa-miR-130b-3p	86.4379	NM_005436
CCDC6	hsa-miR-130a-3p	86.4379	NM_005436
CCDC6	hsa-miR-557	86.1153	NM_005436
CCDC6	hsa-miR-3688-3p	85.9793	NM_005436
CCDC6	hsa-miR-520f-3p	85.9487	NM_005436
CCDC6	hsa-miR-4291	85.9111	NM_005436
CCDC6	hsa-miR-4473	85.8332	NM_005436
CCDC6	hsa-miR-302a-5p	85.4141	NM_005436
CCDC6	hsa-miR-4277	85.0537	NM_005436
CCDC6	hsa-miR-3685	84.9865	NM_005436
CCDC6	hsa-miR-8485	84.6075	NM_005436
CCDC6	hsa-miR-7113-5p	84.4291	NM_005436
CCDC6	hsa-miR-4465	84.2853	NM_005436
CCDC6	hsa-miR-8057	83.969	NM_005436
CCDC6	hsa-miR-1273h-3p	83.8795	NM_005436
CCDC6	hsa-miR-760	83.8195	NM_005436
CCDC6	hsa-miR-3143	83.5466	NM_005436
CCDC6	hsa-miR-6739-3p	83.0579	NM_005436
CCDC6	hsa-miR-586	82.9392	NM_005436
CCDC6	hsa-miR-647	82.8754	NM_005436
CCDC6	hsa-miR-4251	82.6408	NM_005436
CCDC6	hsa-miR-4771	82.3189	NM_005436
CCDC6	hsa-miR-3920	82.2745	NM_005436
CCDC6	hsa-miR-93-3p	82.2352	NM_005436
CCDC6	hsa-miR-4663	82.0286	NM_005436
CCDC6	hsa-miR-635	81.9405	NM_005436

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Motifs and transcription factors (TFs) regulating CCDC6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC6	metacluster_135.11	NR2C2 (directAnnotation).
CCDC6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CCDC6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CCDC6	metacluster_7.13	ZFX (directAnnotation).
CCDC6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CCDC6	cisbp__M00968	MTF2 (directAnnotation).
CCDC6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CCDC6	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CCDC6	cisbp__M00341	PAX6 (directAnnotation).
CCDC6	metacluster_198.3	ZFP64 (directAnnotation).
CCDC6	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CCDC6	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CCDC6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CCDC6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CCDC6	cisbp__M00788	ZFY (inferredBy_Orthology).
CCDC6	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CCDC6	metacluster_175.1	ZNF283 (directAnnotation).
CCDC6	hdpi__ZNF304	ZNF304 (directAnnotation).
CCDC6	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CCDC6	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CCDC6	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CCDC6	transfac_pro__M01199	TRIM28 (directAnnotation).
CCDC6	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CCDC6	metacluster_151.2	ZNF23 (directAnnotation).
CCDC6	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CCDC6	transfac_pro__M03806	ZBTB7C (directAnnotation).
CCDC6	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."