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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC50

Summary for CCDC50

Gene information	Gene symbol	CCDC50
	Ensembl ID	ENSG00000152492
	Entrez ID	152137
	Gene name	coiled-coil domain containing 50
	Synonyms	C3orf6\|DFNA44\|Ymer
	Gene type	protein_coding
	UniProtAcc	Q8IVM0

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Dataset with differentially expressed gene: CCDC50

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.515877	2.77e-36
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.305921	3.69e-37
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.42259	1.87e-21
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.383491	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-1.56525	7.63e-04
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.482662	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	pDCs	-0.954526	4.49e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	1.05592	3.94e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.459938	2.25e-16

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Expression of CCDC50 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC50

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC50

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC50	hsa-miR-670-3p	85.2859	NM_174908
CCDC50	hsa-miR-6768-5p	84.7361	NM_174908
CCDC50	hsa-miR-4768-3p	84.062	NM_174908
CCDC50	hsa-miR-6744-5p	83.6377	NM_174908
CCDC50	hsa-miR-371a-5p	83.494	NM_174908
CCDC50	hsa-miR-4282	83.3616	NM_174908
CCDC50	hsa-miR-7-2-3p	83.3189	NM_174908
CCDC50	hsa-miR-7-1-3p	83.3189	NM_174908
CCDC50	hsa-miR-4251	83.2984	NM_174908
CCDC50	hsa-miR-4446-5p	83.1408	NM_174908
CCDC50	hsa-miR-371b-5p	83.0941	NM_174908
CCDC50	hsa-miR-616-5p	83.0941	NM_174908
CCDC50	hsa-miR-373-5p	83.0941	NM_174908
CCDC50	hsa-miR-339-5p	82.69	NM_174908
CCDC50	hsa-miR-4733-5p	82.1027	NM_174908
CCDC50	hsa-miR-501-3p	81.8191	NM_174908
CCDC50	hsa-miR-502-3p	81.8191	NM_174908
CCDC50	hsa-miR-513a-3p	81.5655	NM_174908
CCDC50	hsa-miR-513c-3p	81.5655	NM_174908
CCDC50	hsa-miR-1537-5p	81.3511	NM_174908
CCDC50	hsa-miR-4704-3p	81.1704	NM_174908
CCDC50	hsa-miR-95-5p	81.1429	NM_174908
CCDC50	hsa-miR-3680-3p	80.9362	NM_174908
CCDC50	hsa-miR-3065-5p	80.6945	NM_174908
CCDC50	hsa-miR-101-5p	80.3668	NM_174908
CCDC50	hsa-miR-4524a-3p	80.3448	NM_174908
CCDC50	hsa-miR-5197-3p	80.1529	NM_174908

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Motifs and transcription factors (TFs) regulating CCDC50

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC50	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CCDC50	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CCDC50	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CCDC50	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CCDC50	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CCDC50	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CCDC50	hdpi__ETV4	ETV4 (directAnnotation).
CCDC50	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CCDC50	transfac_pro__M04866	HDAC2 (directAnnotation).
CCDC50	jaspar__MA1122.1	TFDP1 (directAnnotation).
CCDC50	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CCDC50	kznf__ZNF777_Imbeault2017_OM_MEME	ZNF777 (directAnnotation).
CCDC50	jaspar__MA1948.1	ETV5 (directAnnotation).
CCDC50	transfac_pro__M05539	OSR2 (inferredBy_Orthology).
CCDC50	metacluster_93.4	BCL6B (directAnnotation).
CCDC50	metacluster_155.27	ZFX; ZNF667 (directAnnotation).
CCDC50	dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1	ZFP91 (directAnnotation).
CCDC50	taipale_tf_pairs__GCM1_FOXO1_RTMAATAMGGGYRN_CAP	FOXO1; GCM1 (directAnnotation).
CCDC50	metacluster_135.11	NR2C2 (directAnnotation).
CCDC50	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CCDC50	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CCDC50	metacluster_7.13	ZFX (directAnnotation).
CCDC50	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CCDC50	cisbp__M00968	MTF2 (directAnnotation).
CCDC50	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CCDC50	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CCDC50	cisbp__M00341	PAX6 (directAnnotation).
CCDC50	metacluster_198.3	ZFP64 (directAnnotation).
CCDC50	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CCDC50	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CCDC50	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CCDC50	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CCDC50	cisbp__M00788	ZFY (inferredBy_Orthology).
CCDC50	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CCDC50	metacluster_175.1	ZNF283 (directAnnotation).
CCDC50	hdpi__ZNF304	ZNF304 (directAnnotation).
CCDC50	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CCDC50	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CCDC50	transfac_pro__M01199	TRIM28 (directAnnotation).
CCDC50	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CCDC50	metacluster_151.2	ZNF23 (directAnnotation).
CCDC50	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC50	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CCDC50	transfac_pro__M03806	ZBTB7C (directAnnotation).
CCDC50	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC50	cisbp__M02645	ETS1 (directAnnotation).
CCDC50	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
CCDC50	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CCDC50	jaspar__MA0748.2	YY2 (directAnnotation).
CCDC50	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."