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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC186

Summary for CCDC186

Gene information	Gene symbol	CCDC186
	Ensembl ID	ENSG00000165813
	Entrez ID	55088
	Gene name	coiled-coil domain containing 186
	Synonyms	C10orf118\|CCCP-1\|FLJ10188\|FLJ35301\|golgin104
	Gene type	protein_coding
	UniProtAcc	Q7Z3E2

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Dataset with differentially expressed gene: CCDC186

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.712409	2.42e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.324626	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.448976	0.00e+00

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Expression of CCDC186 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC186

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC186

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC186	hsa-miR-6751-5p	89.8925	NM_153249
CCDC186	hsa-miR-9500	89.851	NM_018017
CCDC186	hsa-miR-153-5p	89.7711	NM_018017
CCDC186	hsa-miR-4531	89.4872	NM_018017
CCDC186	hsa-miR-144-3p	89.4412	NM_018017
CCDC186	hsa-miR-6803-5p	89.4108	NM_153249
CCDC186	hsa-let-7a-3p	88.7238	NM_001321829
CCDC186	hsa-miR-98-3p	88.7238	NM_001321829
CCDC186	hsa-miR-380-3p	88.6902	NM_018017
CCDC186	hsa-miR-3606-3p	87.9957	NM_018017
CCDC186	hsa-miR-3663-3p	87.8811	NM_018017
CCDC186	hsa-miR-6809-3p	87.758	NM_153249
CCDC186	hsa-miR-4438	87.725	NM_018017
CCDC186	hsa-miR-5010-3p	86.9326	NM_018017
CCDC186	hsa-miR-4668-5p	86.9298	NM_153249
CCDC186	hsa-miR-335-3p	86.8551	NM_001321829
CCDC186	hsa-miR-4796-5p	86.5177	NM_153249
CCDC186	hsa-miR-3613-3p	86.3492	NM_001321829
CCDC186	hsa-miR-5695	86.2264	NM_018017
CCDC186	hsa-miR-877-3p	86.1828	NM_018017
CCDC186	hsa-miR-518c-5p	86.1759	NM_001321829
CCDC186	hsa-miR-32-5p	86.0547	NM_001321829
CCDC186	hsa-miR-92a-3p	86.0547	NM_001321829
CCDC186	hsa-miR-92b-3p	86.0547	NM_001321829
CCDC186	hsa-miR-1224-5p	85.9549	NM_153249
CCDC186	hsa-miR-129-1-3p	85.4073	NM_001321829
CCDC186	hsa-miR-129-2-3p	85.4073	NM_001321829
CCDC186	hsa-miR-4698	85.3518	NM_001321829
CCDC186	hsa-miR-363-3p	84.9601	NM_001321829
CCDC186	hsa-miR-25-3p	84.9601	NM_001321829
CCDC186	hsa-miR-367-3p	84.9601	NM_001321829
CCDC186	hsa-miR-519e-5p	84.7808	NM_018017
CCDC186	hsa-miR-515-5p	84.7808	NM_018017
CCDC186	hsa-miR-3180-5p	84.6919	NM_018017
CCDC186	hsa-miR-7-5p	84.4147	NM_001321829
CCDC186	hsa-miR-3942-3p	84.1642	NM_153249
CCDC186	hsa-miR-12135	84.092	NM_018017
CCDC186	hsa-miR-519d-5p	83.6446	NM_018017
CCDC186	hsa-miR-4789-3p	83.5322	NM_153249
CCDC186	hsa-miR-4775	83.217	NM_018017
CCDC186	hsa-miR-892b	82.8842	NM_018017
CCDC186	hsa-miR-3177-5p	82.4485	NM_018017
CCDC186	hsa-miR-767-5p	82.358	NM_018017
CCDC186	hsa-miR-4267	82.2604	NM_018017
CCDC186	hsa-miR-520f-5p	82.2123	NM_153249
CCDC186	hsa-miR-586	82.183	NM_001321829
CCDC186	hsa-miR-12132	82.0811	NM_018017
CCDC186	hsa-miR-202-3p	82.0344	NM_153249
CCDC186	hsa-miR-2117	81.9078	NM_153249
CCDC186	hsa-miR-4799-5p	81.8086	NM_018017

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Motifs and transcription factors (TFs) regulating CCDC186

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC186	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CCDC186	transfac_pro__M04617	ZBTB7A (directAnnotation).
CCDC186	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CCDC186	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CCDC186	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CCDC186	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CCDC186	transfac_pro__M07387	ZBTB7A (directAnnotation).
CCDC186	transfac_pro__M07436	WT1 (directAnnotation).
CCDC186	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CCDC186	transfac_pro__M00716	ZBTB14 (directAnnotation).
CCDC186	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CCDC186	hdpi__HIP2	UBE2K (directAnnotation).
CCDC186	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CCDC186	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CCDC186	transfac_pro__M04893	TAF1 (directAnnotation).
CCDC186	transfac_pro__M03876	ZBTB33 (directAnnotation).
CCDC186	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CCDC186	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CCDC186	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CCDC186	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CCDC186	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CCDC186	metacluster_135.11	NR2C2 (directAnnotation).
CCDC186	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CCDC186	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CCDC186	metacluster_7.13	ZFX (directAnnotation).
CCDC186	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CCDC186	cisbp__M00968	MTF2 (directAnnotation).
CCDC186	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CCDC186	cisbp__M00341	PAX6 (directAnnotation).
CCDC186	metacluster_198.3	ZFP64 (directAnnotation).
CCDC186	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CCDC186	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CCDC186	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CCDC186	cisbp__M00788	ZFY (inferredBy_Orthology).
CCDC186	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CCDC186	metacluster_175.1	ZNF283 (directAnnotation).
CCDC186	hdpi__ZNF304	ZNF304 (directAnnotation).
CCDC186	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CCDC186	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CCDC186	transfac_pro__M01199	TRIM28 (directAnnotation).
CCDC186	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CCDC186	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC186	transfac_pro__M03806	ZBTB7C (directAnnotation).
CCDC186	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC186	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CCDC186	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CCDC186	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CCDC186	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CCDC186	transfac_pro__M01253	CNOT3 (directAnnotation).
CCDC186	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."