Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CBX6

Summary for CBX6

Gene information	Gene symbol	CBX6
	Ensembl ID	ENSG00000183741
	Entrez ID	23466
	Gene name	chromobox 6
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	O95503

Top

Dataset with differentially expressed gene: CBX6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.289133	4.59e-16
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.446615	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.317961	9.90e-29
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.287852	9.52e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.38501	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.345289	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.572745	0.00e+00

Top

Expression of CBX6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CBX6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CBX6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CBX6	hsa-miR-6721-5p	88.1629	NM_001303494
CBX6	hsa-miR-361-3p	87.174	NM_001303494
CBX6	hsa-miR-4712-3p	87.042	NM_001303494
CBX6	hsa-miR-296-5p	86.9721	NM_001303494
CBX6	hsa-miR-3613-3p	86.7263	NM_001303494
CBX6	hsa-miR-570-3p	86.3722	NM_001303494
CBX6	hsa-miR-3612	85.5603	NM_001303494
CBX6	hsa-miR-650	85.5603	NM_001303494
CBX6	hsa-miR-4260	85.4608	NM_001303494
CBX6	hsa-miR-4492	85.4052	NM_001303494
CBX6	hsa-miR-3184-5p	85.3931	NM_001303494
CBX6	hsa-miR-423-5p	85.3931	NM_001303494
CBX6	hsa-miR-450a-2-3p	85.2485	NM_001303494
CBX6	hsa-miR-548t-3p	84.5992	NM_001303494
CBX6	hsa-miR-548aa	84.5992	NM_001303494
CBX6	hsa-miR-548ap-3p	84.5992	NM_001303494
CBX6	hsa-miR-130a-5p	83.5546	NM_001303494
CBX6	hsa-miR-6835-5p	83.4536	NM_001303494
CBX6	hsa-miR-7152-5p	83.4037	NM_001303494
CBX6	hsa-miR-5572	83.2724	NM_001303494
CBX6	hsa-miR-301a-3p	83.1114	NM_001303494
CBX6	hsa-miR-3666	83.1114	NM_001303494
CBX6	hsa-miR-130a-3p	83.1114	NM_001303494
CBX6	hsa-miR-301b-3p	83.1114	NM_001303494
CBX6	hsa-miR-4295	83.1114	NM_001303494
CBX6	hsa-miR-454-3p	83.1114	NM_001303494
CBX6	hsa-miR-130b-3p	83.1114	NM_001303494
CBX6	hsa-miR-425-5p	83.0625	NM_001303494
CBX6	hsa-miR-519c-3p	82.8706	NM_001303494
CBX6	hsa-miR-519a-3p	82.8706	NM_001303494
CBX6	hsa-miR-519b-3p	82.8706	NM_001303494
CBX6	hsa-miR-5682	82.3971	NM_001303494
CBX6	hsa-miR-4533	82.0498	NM_001303494
CBX6	hsa-miR-5591-5p	81.6076	NM_001303494
CBX6	hsa-miR-4487	80.8862	NM_001303494
CBX6	hsa-miR-4501	80.4417	NM_001303494

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CBX6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CBX6	jaspar__MA1483.2	ELF2 (directAnnotation).
CBX6	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CBX6	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
CBX6	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CBX6	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CBX6	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CBX6	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
CBX6	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
CBX6	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CBX6	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
CBX6	transfac_pro__M01973	PLAG1 (directAnnotation).
CBX6	tfdimers__MD00151	CHURC1 (directAnnotation).
CBX6	transfac_pro__M04817	ZBTB33 (directAnnotation).
CBX6	cisbp__M00139	ZNF281 (inferredBy_Orthology).
CBX6	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CBX6	metacluster_3.14	WT1; WT1 (directAnnotation).
CBX6	transfac_pro__M01122	ZNF219 (directAnnotation).
CBX6	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CBX6	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
CBX6	cisbp__M00249	WT1 (directAnnotation).
CBX6	cisbp__M00135	ZBTB7B (inferredBy_Orthology).
CBX6	tfdimers__MD00366	MTF1; OVOL2 (directAnnotation).
CBX6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CBX6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CBX6	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CBX6	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CBX6	transfac_pro__M01303	SP1 (directAnnotation).
CBX6	homer__GGGGGGGG_Maz	MAZ (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."