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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CBX5

Summary for CBX5

Gene information	Gene symbol	CBX5
	Ensembl ID	ENSG00000094916
	Entrez ID	23468
	Gene name	chromobox 5
	Synonyms	HP1\|HP1-ALPHA\|HP1Hs-alpha
	Gene type	protein_coding
	UniProtAcc	P45973

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Dataset with differentially expressed gene: CBX5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.327689	1.19e-24
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.312374	1.41e-14
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.352919	2.16e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.339802	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.551292	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.37558	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.287197	0.00e+00

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Expression of CBX5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CBX5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CBX5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CBX5	hsa-miR-3927-3p	88.5051	NM_001127321
CBX5	hsa-miR-381-3p	88.3041	NM_001127321
CBX5	hsa-miR-300	88.3041	NM_001127321
CBX5	hsa-miR-646	87.9801	NM_001127321
CBX5	hsa-miR-4282	87.6504	NM_001127321
CBX5	hsa-miR-887-5p	87.649	NM_001127321
CBX5	hsa-miR-6783-3p	87.6248	NM_001127321
CBX5	hsa-miR-4668-3p	87.2003	NM_001127321
CBX5	hsa-miR-1343-3p	86.3618	NM_001127321
CBX5	hsa-miR-3192-5p	86.33	NM_001127321
CBX5	hsa-miR-5688	86.3095	NM_001127321
CBX5	hsa-miR-4668-5p	86.2651	NM_001127321
CBX5	hsa-miR-4297	85.7627	NM_001127321
CBX5	hsa-miR-2052	85.1788	NM_001127321
CBX5	hsa-miR-4494	85.1687	NM_001127321
CBX5	hsa-miR-4719	84.9743	NM_001127321
CBX5	hsa-miR-495-3p	84.4832	NM_001127321
CBX5	hsa-miR-6507-5p	84.4624	NM_001127321
CBX5	hsa-miR-3652	84.1158	NM_001127321
CBX5	hsa-miR-4430	84.1158	NM_001127321
CBX5	hsa-miR-371a-5p	83.8498	NM_001127321
CBX5	hsa-miR-4797-3p	83.6929	NM_001127321
CBX5	hsa-miR-4716-3p	83.6797	NM_001127321
CBX5	hsa-miR-6794-5p	83.6797	NM_001127321
CBX5	hsa-miR-624-3p	83.5428	NM_001127321
CBX5	hsa-miR-651-5p	83.4436	NM_001127321
CBX5	hsa-miR-4696	83.2741	NM_001127321
CBX5	hsa-miR-5680	83.1882	NM_001127321
CBX5	hsa-miR-1827	83.1852	NM_001127321
CBX5	hsa-miR-625-5p	83.0702	NM_001127321
CBX5	hsa-miR-9986	82.7354	NM_001127321
CBX5	hsa-miR-1294	82.7354	NM_001127321
CBX5	hsa-miR-3925-3p	82.093	NM_001127321
CBX5	hsa-miR-618	82.0928	NM_001127321
CBX5	hsa-miR-6895-5p	81.8013	NM_001127321
CBX5	hsa-miR-5196-3p	81.7677	NM_001127321
CBX5	hsa-miR-630	80.9687	NM_001127321
CBX5	hsa-miR-4441	80.8719	NM_001127321
CBX5	hsa-miR-4768-3p	80.7155	NM_001127321
CBX5	hsa-miR-548ap-3p	80.359	NM_001127321
CBX5	hsa-miR-548aa	80.359	NM_001127321
CBX5	hsa-miR-548t-3p	80.359	NM_001127321
CBX5	hsa-miR-539-5p	80.2008	NM_001127321
CBX5	hsa-miR-4723-5p	80.1163	NM_001127321

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Motifs and transcription factors (TFs) regulating CBX5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CBX5	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CBX5	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CBX5	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CBX5	transfac_pro__M04950	EGR1 (directAnnotation).
CBX5	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CBX5	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CBX5	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CBX5	transfac_pro__M00652	NRF1 (directAnnotation).
CBX5	transfac_pro__M04866	HDAC2 (directAnnotation).
CBX5	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CBX5	hdpi__TP73	TP73 (directAnnotation).
CBX5	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
CBX5	transfac_pro__M04944	GABPA (directAnnotation).
CBX5	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
CBX5	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
CBX5	metacluster_55.5	ZNF541 (directAnnotation).
CBX5	cisbp__M02645	ETS1 (directAnnotation).
CBX5	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
CBX5	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
CBX5	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CBX5	jaspar__MA0502.2	NFYB (directAnnotation).
CBX5	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CBX5	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CBX5	transfac_pro__M04918	EGR1 (directAnnotation).
CBX5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CBX5	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CBX5	cisbp__M08198	ELF1 (directAnnotation).
CBX5	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
CBX5	transfac_pro__M06032	ZNF727 (directAnnotation).
CBX5	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
CBX5	jaspar__MA1483.2	ELF2 (directAnnotation).
CBX5	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CBX5	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CBX5	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
CBX5	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
CBX5	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
CBX5	taipale_tf_pairs__POU2F1_ETV1_NCCGGATATGCAN_CAP_repr	ETV1; POU2F1 (directAnnotation).
CBX5	transfac_pro__M02898	SMAD3 (directAnnotation).
CBX5	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CBX5	hdpi__HIP2	UBE2K (directAnnotation).
CBX5	hdpi__NRL	NRL (directAnnotation).
CBX5	transfac_pro__M00430	E2F1 (directAnnotation).
CBX5	metacluster_3.14	WT1; WT1 (directAnnotation).
CBX5	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CBX5	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CBX5	jaspar__MA0748.2	YY2 (directAnnotation).
CBX5	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CBX5	kznf__ZNF736_Imbeault2017_OM_RCADE	ZNF736 (directAnnotation).
CBX5	metacluster_136.2	RFX1; RFX2; RFX2; RFX3; RFX3; RFX4; RFX5; RFX5; RFX5; RFX5; RFX5; RFX5; RFX5; RFX7; RFX7; RFXANK; RFXAP (directAnnotation). RFX3; RFX3; RFX4 (inferredBy_Orthology).
CBX5	hocomoco__KAISO_HUMAN.H11MO.2.A	ZBTB33 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CBX5	"Copper"	DB09130	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."