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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CBL

Summary for CBL

Gene information	Gene symbol	CBL
	Ensembl ID	ENSG00000110395
	Entrez ID	867
	Gene name	Cbl proto-oncogene
	Synonyms	c-Cbl\|CBL2\|RNF55
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CBL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.700202	2.82e-02

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Expression of CBL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CBL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CBL	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CBL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CBL	hsa-miR-5692a	86.2442	NM_005188
CBL	hsa-miR-4744	86.1298	NM_005188
CBL	hsa-miR-4311	85.9869	NM_005188
CBL	hsa-miR-371b-5p	85.858	NM_005188
CBL	hsa-miR-373-5p	85.858	NM_005188
CBL	hsa-miR-5589-3p	85.8223	NM_005188
CBL	hsa-miR-8055	85.622	NM_005188
CBL	hsa-miR-3529-3p	85.3645	NM_005188
CBL	hsa-miR-3667-3p	85.3179	NM_005188
CBL	hsa-miR-10526-3p	85.141	NM_005188
CBL	hsa-miR-149-5p	84.3497	NM_005188
CBL	hsa-miR-4768-3p	83.841	NM_005188
CBL	hsa-miR-197-3p	83.8203	NM_005188
CBL	hsa-miR-548c-3p	83.3912	NM_005188
CBL	hsa-miR-5003-3p	83.1068	NM_005188
CBL	hsa-miR-5681a	82.6514	NM_005188
CBL	hsa-miR-6825-5p	82.4583	NM_005188
CBL	hsa-miR-4700-3p	82.3668	NM_005188
CBL	hsa-miR-3658	82.1928	NM_005188
CBL	hsa-miR-2355-5p	82.0374	NM_005188
CBL	hsa-miR-4533	81.9995	NM_005188
CBL	hsa-miR-6882-3p	81.9705	NM_005188
CBL	hsa-miR-3116	81.6972	NM_005188
CBL	hsa-miR-5010-3p	81.2661	NM_005188
CBL	hsa-miR-4773	80.6203	NM_005188
CBL	hsa-miR-1251-3p	80.2185	NM_005188
CBL	hsa-miR-6891-5p	80.1859	NM_005188

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Motifs and transcription factors (TFs) regulating CBL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CBL	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CBL	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CBL	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CBL	transfac_pro__M04617	ZBTB7A (directAnnotation).
CBL	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CBL	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CBL	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CBL	transfac_pro__M07387	ZBTB7A (directAnnotation).
CBL	transfac_pro__M07436	WT1 (directAnnotation).
CBL	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CBL	transfac_pro__M00716	ZBTB14 (directAnnotation).
CBL	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CBL	hdpi__HIP2	UBE2K (directAnnotation).
CBL	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CBL	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CBL	transfac_pro__M04893	TAF1 (directAnnotation).
CBL	transfac_pro__M03876	ZBTB33 (directAnnotation).
CBL	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CBL	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CBL	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CBL	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CBL	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."