Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CASK

Summary for CASK

Gene information	Gene symbol	CASK
	Ensembl ID	ENSG00000147044
	Entrez ID	8573
	Gene name	calcium/calmodulin dependent serine protein kinase
	Synonyms	CAGH39\|FGS4\|LIN2\|TNRC8
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: CASK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.425589	0.00e+00

Top

Expression of CASK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CASK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CASK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CASK	hsa-miR-12129	87.5199	NM_001126054
CASK	hsa-miR-6789-5p	87.3183	NM_003688
CASK	hsa-miR-1912-5p	87.225	NM_001126054
CASK	hsa-miR-143-5p	86.8612	NM_001126054
CASK	hsa-miR-216b-5p	86.6622	NM_003688
CASK	hsa-miR-561-3p	86.5406	NM_001126054
CASK	hsa-miR-6071	86.4184	NM_003688
CASK	hsa-miR-7110-3p	85.7896	NM_003688
CASK	hsa-miR-4509	85.7731	NM_003688
CASK	hsa-miR-186-5p	85.6956	NM_001126054
CASK	hsa-miR-369-3p	85.6606	NM_003688
CASK	hsa-miR-6505-5p	85.2905	NM_001126054
CASK	hsa-miR-3605-5p	85.0724	NM_003688
CASK	hsa-miR-194-5p	84.963	NM_001126054
CASK	hsa-miR-196b-5p	84.9437	NM_001126054
CASK	hsa-miR-196a-5p	84.9437	NM_001126054
CASK	hsa-miR-26a-2-3p	84.6318	NM_003688
CASK	hsa-miR-26a-1-3p	84.6318	NM_003688
CASK	hsa-miR-6727-3p	84.6196	NM_001126054
CASK	hsa-miR-4470	84.3669	NM_001126054
CASK	hsa-miR-6809-3p	84.0689	NM_003688
CASK	hsa-miR-1236-3p	83.8102	NM_003688
CASK	hsa-miR-7-2-3p	83.0762	NM_003688
CASK	hsa-miR-7-1-3p	83.0762	NM_003688
CASK	hsa-miR-3910	82.4848	NM_001126054
CASK	hsa-miR-1537-5p	82.3885	NM_003688
CASK	hsa-miR-331-3p	81.6907	NM_001126054
CASK	hsa-miR-4266	81.4525	NM_003688
CASK	hsa-miR-34b-3p	81.3483	NM_003688
CASK	hsa-miR-3692-3p	81.151	NM_003688
CASK	hsa-miR-593-3p	80.9408	NM_003688
CASK	hsa-miR-6895-3p	80.9408	NM_003688
CASK	hsa-miR-4303	80.8391	NM_003688
CASK	hsa-miR-377-3p	80.7247	NM_001126054
CASK	hsa-miR-4275	80.2237	NM_001126054
CASK	hsa-miR-3944-5p	80.0526	NM_001126054

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CASK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CASK	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CASK	metacluster_7.13	ZFX (directAnnotation).
CASK	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CASK	cisbp__M00968	MTF2 (directAnnotation).
CASK	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CASK	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CASK	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CASK	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CASK	cisbp__M00788	ZFY (inferredBy_Orthology).
CASK	metacluster_175.1	ZNF283 (directAnnotation).
CASK	hdpi__ZNF304	ZNF304 (directAnnotation).
CASK	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CASK	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CASK	transfac_pro__M01199	TRIM28 (directAnnotation).
CASK	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CASK	metacluster_151.2	ZNF23 (directAnnotation).
CASK	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CASK	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CASK	transfac_pro__M03806	ZBTB7C (directAnnotation).
CASK	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CASK	"Formic acid"	DB01942	small molecule
CASK	"Fostamatinib"	DB12010	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."