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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CAMK4

Summary for CAMK4

Gene information	Gene symbol	CAMK4
	Ensembl ID	ENSG00000152495
	Entrez ID	814
	Gene name	calcium/calmodulin dependent protein kinase IV
	Synonyms	CaMK-GR\|CaMKIV
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CAMK4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.250318	9.70e-34
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.527828	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.279281	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.291806	1.10e-14
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.30267	1.65e-38
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.481434	0.00e+00

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Expression of CAMK4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAMK4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAMK4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAMK4	hsa-miR-190a-3p	86.1195	NM_001323375
CAMK4	hsa-miR-6721-5p	85.9826	NM_001323375
CAMK4	hsa-miR-651-3p	85.6227	NM_001323375
CAMK4	hsa-miR-524-5p	85.53	NM_001323375
CAMK4	hsa-miR-520d-5p	85.53	NM_001323375
CAMK4	hsa-miR-6804-3p	85.35	NM_001323374
CAMK4	hsa-miR-30e-5p	85.2466	NM_001323374
CAMK4	hsa-miR-30c-5p	85.2466	NM_001323374
CAMK4	hsa-miR-30b-5p	85.2466	NM_001323374
CAMK4	hsa-miR-30a-5p	85.2466	NM_001323374
CAMK4	hsa-miR-30d-5p	85.2466	NM_001323374
CAMK4	hsa-miR-5011-5p	85.1311	NM_001323375
CAMK4	hsa-miR-511-5p	85.0538	NM_001323375
CAMK4	hsa-miR-7159-3p	84.9447	NM_001323375
CAMK4	hsa-miR-5695	84.7004	NM_001323375
CAMK4	hsa-miR-10527-5p	84.1803	NM_001323375
CAMK4	hsa-miR-590-3p	84.162	NM_001323375
CAMK4	hsa-miR-607	84.1097	NM_001323374
CAMK4	hsa-miR-548c-3p	84.0845	NM_001323375
CAMK4	hsa-miR-4717-3p	83.8786	NM_001323374
CAMK4	hsa-miR-4772-3p	83.8416	NM_001323375
CAMK4	hsa-miR-7152-5p	83.7497	NM_001323374
CAMK4	hsa-miR-568	83.4804	NM_001323374
CAMK4	hsa-miR-4314	83.3398	NM_001323375
CAMK4	hsa-miR-10393-5p	83.1843	NM_001323375
CAMK4	hsa-miR-4309	82.8009	NM_001323375
CAMK4	hsa-miR-6507-5p	82.5995	NM_001323375
CAMK4	hsa-miR-766-3p	82.4648	NM_001323375
CAMK4	hsa-miR-3198	82.4629	NM_001323375
CAMK4	hsa-miR-8066	82.3099	NM_001323375
CAMK4	hsa-miR-944	82.2558	NM_001323375
CAMK4	hsa-miR-4742-3p	82.2075	NM_001323375
CAMK4	hsa-miR-12131	81.965	NM_001323375
CAMK4	hsa-miR-4635	81.7944	NM_001323375
CAMK4	hsa-miR-4476	81.7222	NM_001323375
CAMK4	hsa-miR-34a-5p	81.555	NM_001323374
CAMK4	hsa-miR-449a	81.555	NM_001323374
CAMK4	hsa-miR-4999-5p	81.3775	NM_001323375
CAMK4	hsa-miR-4789-3p	80.5458	NM_001323375
CAMK4	hsa-miR-4735-5p	80.204	NM_001323375

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Motifs and transcription factors (TFs) regulating CAMK4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAMK4	metacluster_151.2	ZNF23 (directAnnotation).
CAMK4	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CAMK4	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CAMK4	transfac_pro__M03813	POU3F3 (directAnnotation).
CAMK4	transfac_pro__M06488	ZNF595 (directAnnotation).
CAMK4	cisbp__M07938	E2F1 (directAnnotation).
CAMK4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CAMK4	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CAMK4	transfac_pro__M12697	ZNF142 (directAnnotation).
CAMK4	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CAMK4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CAMK4	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CAMK4	transfac_pro__M00938	E2F1 (directAnnotation).
CAMK4	transfac_pro__M02090	E2F4 (directAnnotation).
CAMK4	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CAMK4	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
CAMK4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CAMK4	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
CAMK4	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
CAMK4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CAMK4	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CAMK4	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
CAMK4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CAMK4	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
CAMK4	jaspar__MA1956.1	FOXO1 (directAnnotation).
CAMK4	transfac_pro__M06905	ZNF585B (directAnnotation).
CAMK4	taipale_tf_pairs__FOXO1_ETV4_RWMAACAGGAARNN_CAP	ETV4; FOXO1 (directAnnotation).
CAMK4	swissregulon__hs__ETV6	ETV6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CAMK4	"3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one"	DB07676	small molecule
CAMK4	"K-00546"	DB07664	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."