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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CADM1

Summary for CADM1

Gene information	Gene symbol	CADM1
	Ensembl ID	ENSG00000182985
	Entrez ID	23705
	Gene name	cell adhesion molecule 1
	Synonyms	BL2\|IGSF4\|IGSF4A\|Necl-2\|NECL2\|RA175\|ST17\|SYNCAM\|SYNCAM1\|TSLC1
	Gene type	protein_coding
	UniProtAcc	Q9BY67

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Dataset with differentially expressed gene: CADM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.15559	1.25e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.399739	9.14e-19
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.283033	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-1.01096	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.927467	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.470665	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.544319	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.463883	2.41e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.624642	0.00e+00

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Expression of CADM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CADM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE161801_IMiD	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE161801_IMiD	pre	resistant
CADM1	Malignant cells	CPI-SS0B990492C	CADM1_NECTIN3	CADM1	NECTIN3	False	Malignant cells	Fibroblasts	GSE189460	pre	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE189460	pre	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	cDCs	GSE189460	pre	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	cDCs	Malignant cells	GSE189460	pre	resistant
CADM1	Malignant cells	CPI-SS0B990492C	CADM1_NECTIN3	CADM1	NECTIN3	False	Malignant cells	Fibroblasts	GSE189460	pre	sensitive
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE189460	pre	sensitive
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Endothelial cells	Malignant cells	GSE207422_Tor	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Endothelial cells	GSE207422_Tor	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Malignant cells	GSE207422_Tor	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Malignant cells	Plasma cells	GSE207422_Tor	post	resistant
CADM1	Malignant cells	CPI-SS0889E281D	CADM1_CADM1	CADM1	CADM1	False	Plasma cells	Malignant cells	GSE207422_Tor	post	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CADM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CADM1	hsa-miR-193b-3p	87.5711	NM_001098517
CADM1	hsa-miR-193a-3p	87.5711	NM_001098517
CADM1	hsa-miR-4468	87.2324	NM_001098517
CADM1	hsa-miR-4773	86.5505	NM_014333
CADM1	hsa-miR-6794-5p	85.3999	NM_014333
CADM1	hsa-miR-4716-3p	85.3999	NM_014333
CADM1	hsa-miR-520f-5p	85.3712	NM_014333
CADM1	hsa-miR-548at-5p	85.1506	NM_001098517
CADM1	hsa-miR-1252-5p	84.3394	NM_014333
CADM1	hsa-miR-6732-3p	84.1627	NM_014333
CADM1	hsa-miR-7977	84.0581	NM_014333
CADM1	hsa-miR-4666a-3p	83.9275	NM_001098517
CADM1	hsa-miR-505-3p	83.7262	NM_014333
CADM1	hsa-miR-4297	83.2635	NM_014333
CADM1	hsa-miR-7152-5p	83.0811	NM_014333
CADM1	hsa-miR-4474-3p	83.0491	NM_001098517
CADM1	hsa-miR-4477a	82.5658	NM_014333
CADM1	hsa-miR-4738-3p	82.3767	NM_014333
CADM1	hsa-miR-10401-5p	81.5147	NM_001098517
CADM1	hsa-miR-6739-5p	81.4061	NM_001098517
CADM1	hsa-miR-6733-5p	81.4061	NM_001098517
CADM1	hsa-miR-3151-5p	81.2867	NM_001098517
CADM1	hsa-miR-4690-5p	81.2301	NM_001098517
CADM1	hsa-miR-921	81.2115	NM_014333
CADM1	hsa-miR-486-5p	80.7471	NM_014333
CADM1	hsa-miR-6760-3p	80.6946	NM_001098517
CADM1	hsa-miR-148a-3p	80.617	NM_001098517
CADM1	hsa-miR-152-3p	80.617	NM_001098517
CADM1	hsa-miR-148b-3p	80.617	NM_001098517
CADM1	hsa-miR-5584-5p	80.2598	NM_014333

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Motifs and transcription factors (TFs) regulating CADM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CADM1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CADM1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CADM1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CADM1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CADM1	transfac_pro__M04617	ZBTB7A (directAnnotation).
CADM1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CADM1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CADM1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CADM1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CADM1	transfac_pro__M07387	ZBTB7A (directAnnotation).
CADM1	transfac_pro__M07436	WT1 (directAnnotation).
CADM1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CADM1	transfac_pro__M00716	ZBTB14 (directAnnotation).
CADM1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CADM1	hdpi__HIP2	UBE2K (directAnnotation).
CADM1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CADM1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CADM1	transfac_pro__M04893	TAF1 (directAnnotation).
CADM1	transfac_pro__M03876	ZBTB33 (directAnnotation).
CADM1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CADM1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CADM1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CADM1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CADM1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CADM1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CADM1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
CADM1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
CADM1	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
CADM1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
CADM1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CADM1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CADM1	transfac_pro__M04844	MAX (directAnnotation).
CADM1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CADM1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CADM1	transfac_pro__M05440	NKX2-3 (directAnnotation).
CADM1	metacluster_161.31	PRRX2 (directAnnotation).
CADM1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
CADM1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CADM1	transfac_pro__M04862	NRF1 (directAnnotation).
CADM1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CADM1	metacluster_141.4	GLIS2 (directAnnotation).
CADM1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
CADM1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
CADM1	jaspar__MA1708.1	ETV7 (directAnnotation).
CADM1	swissregulon__hs__DMC1	DMC1 (directAnnotation).
CADM1	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
CADM1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
CADM1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CADM1	transfac_pro__M06085	ZNF26 (directAnnotation).
CADM1	transfac_pro__M06388	ZNF677 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."