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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CACNA2D1

Summary for CACNA2D1

Gene information	Gene symbol	CACNA2D1
	Ensembl ID	ENSG00000153956
	Entrez ID	781
	Gene name	calcium voltage-gated channel auxiliary subunit alpha2delta 1
	Synonyms	alpha2delta-1\|CACNA2\|CACNL2A\|LINC01112\|lncRNA-N3\|MHS3
	Gene type	protein_coding
	UniProtAcc	P54289

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Dataset with differentially expressed gene: CACNA2D1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.92131	1.46e-03

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Expression of CACNA2D1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CACNA2D1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CACNA2D1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CACNA2D1	hsa-miR-548t-5p	89.0514	NM_000722
CACNA2D1	hsa-miR-548az-5p	89.0514	NM_000722
CACNA2D1	hsa-miR-15a-5p	88.4625	NM_000722
CACNA2D1	hsa-miR-16-5p	88.4625	NM_000722
CACNA2D1	hsa-miR-195-5p	88.4625	NM_000722
CACNA2D1	hsa-miR-1305	88.4404	NM_000722
CACNA2D1	hsa-miR-4693-5p	88.2798	NM_000722
CACNA2D1	hsa-let-7f-1-3p	88.2183	NM_000722
CACNA2D1	hsa-let-7b-3p	88.2183	NM_000722
CACNA2D1	hsa-miR-98-3p	88.2183	NM_000722
CACNA2D1	hsa-let-7a-3p	88.2183	NM_000722
CACNA2D1	hsa-miR-6506-5p	88.0895	NM_000722
CACNA2D1	hsa-miR-619-5p	88.0895	NM_000722
CACNA2D1	hsa-miR-568	87.8359	NM_000722
CACNA2D1	hsa-miR-26a-1-3p	87.5723	NM_000722
CACNA2D1	hsa-miR-8063	87.5489	NM_000722
CACNA2D1	hsa-miR-335-3p	87.4033	NM_000722
CACNA2D1	hsa-miR-424-5p	87.37	NM_000722
CACNA2D1	hsa-miR-5089-3p	86.9999	NM_000722
CACNA2D1	hsa-miR-5003-3p	86.7742	NM_000722
CACNA2D1	hsa-miR-7156-3p	86.6904	NM_000722
CACNA2D1	hsa-miR-1468-3p	86.6032	NM_000722
CACNA2D1	hsa-miR-12123	85.5139	NM_000722
CACNA2D1	hsa-miR-497-5p	85.4487	NM_000722
CACNA2D1	hsa-miR-6838-5p	85.0917	NM_000722
CACNA2D1	hsa-miR-4698	84.9757	NM_000722
CACNA2D1	hsa-miR-548d-3p	84.5929	NM_000722
CACNA2D1	hsa-miR-548z	84.5929	NM_000722
CACNA2D1	hsa-miR-548ac	84.5929	NM_000722
CACNA2D1	hsa-miR-548bb-3p	84.5929	NM_000722
CACNA2D1	hsa-miR-548h-3p	84.5929	NM_000722
CACNA2D1	hsa-miR-6887-3p	84.3637	NM_001302890
CACNA2D1	hsa-miR-524-5p	84.2957	NM_000722
CACNA2D1	hsa-miR-520d-5p	84.2957	NM_000722
CACNA2D1	hsa-miR-376a-3p	83.8178	NM_000722
CACNA2D1	hsa-miR-376b-3p	83.8178	NM_000722
CACNA2D1	hsa-miR-3529-3p	83.3375	NM_000722
CACNA2D1	hsa-miR-3974	83.2541	NM_000722
CACNA2D1	hsa-miR-33a-3p	83.1932	NM_000722
CACNA2D1	hsa-miR-4427	82.2597	NM_000722
CACNA2D1	hsa-miR-6727-3p	82.1017	NM_000722
CACNA2D1	hsa-miR-3671	81.357	NM_000722
CACNA2D1	hsa-miR-4775	81.2901	NM_000722
CACNA2D1	hsa-miR-139-5p	81.1254	NM_000722
CACNA2D1	hsa-miR-545-5p	80.7378	NM_000722

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Motifs and transcription factors (TFs) regulating CACNA2D1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CACNA2D1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CACNA2D1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CACNA2D1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CACNA2D1	transfac_pro__M04617	ZBTB7A (directAnnotation).
CACNA2D1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CACNA2D1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CACNA2D1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CACNA2D1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CACNA2D1	transfac_pro__M07387	ZBTB7A (directAnnotation).
CACNA2D1	transfac_pro__M07436	WT1 (directAnnotation).
CACNA2D1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CACNA2D1	transfac_pro__M00716	ZBTB14 (directAnnotation).
CACNA2D1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CACNA2D1	hdpi__HIP2	UBE2K (directAnnotation).
CACNA2D1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CACNA2D1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CACNA2D1	transfac_pro__M04893	TAF1 (directAnnotation).
CACNA2D1	transfac_pro__M03876	ZBTB33 (directAnnotation).
CACNA2D1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CACNA2D1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CACNA2D1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CACNA2D1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CACNA2D1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CACNA2D1	"Cyclandelate"	DB04838	small molecule
CACNA2D1	"Felodipine"	DB01023	small molecule
CACNA2D1	"Gabapentin enacarbil"	DB08872	small molecule
CACNA2D1	"Gabapentin"	DB00996	small molecule
CACNA2D1	"Ibutilide"	DB00308	small molecule
CACNA2D1	"Isradipine"	DB00270	small molecule
CACNA2D1	"Nicardipine"	DB00622	small molecule
CACNA2D1	"Nilvadipine"	DB06712	small molecule
CACNA2D1	"Nisoldipine"	DB00401	small molecule
CACNA2D1	"Nitrendipine"	DB01054	small molecule
CACNA2D1	"Pregabalin"	DB00230	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."