Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: C21orf91

Summary for C21orf91

Gene information	Gene symbol	C21orf91
	Ensembl ID	ENSG00000154642
	Entrez ID	54149
	Gene name	chromosome 21 open reading frame 91
	Synonyms	C21orf14\|C21orf38\|CSSG1\|EURL\|YG81
	Gene type	protein_coding
	UniProtAcc	Q9NYK6

Top

Dataset with differentially expressed gene: C21orf91

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.277288	4.99e-32

Top

Expression of C21orf91 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to C21orf91

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating C21orf91

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
C21orf91	hsa-miR-548h-5p	90.1017	NM_001100421
C21orf91	hsa-miR-548as-5p	90.1017	NM_001100421
C21orf91	hsa-miR-548ak	90.1017	NM_001100421
C21orf91	hsa-miR-548j-5p	90.1017	NM_001100421
C21orf91	hsa-miR-548ar-5p	90.1017	NM_001100421
C21orf91	hsa-miR-548ab	90.1017	NM_001100421
C21orf91	hsa-miR-548b-5p	90.1017	NM_001100421
C21orf91	hsa-miR-4314	89.8847	NM_001100420
C21orf91	hsa-miR-576-5p	89.7109	NM_001100421
C21orf91	hsa-miR-573	89.2483	NM_001100420
C21orf91	hsa-miR-5011-5p	88.8596	NM_001100420
C21orf91	hsa-miR-3616-5p	88.8138	NM_001100420
C21orf91	hsa-miR-543	88.4095	NM_001100420
C21orf91	hsa-miR-4795-3p	88.1105	NM_001100420
C21orf91	hsa-miR-126-5p	87.7236	NM_001100420
C21orf91	hsa-miR-1276	87.5056	NM_001100421
C21orf91	hsa-miR-4477a	87.4787	NM_001100420
C21orf91	hsa-miR-1277-5p	87.3287	NM_001100421
C21orf91	hsa-miR-548c-3p	87.1123	NM_001100421
C21orf91	hsa-miR-32-3p	86.5414	NM_001100420
C21orf91	hsa-miR-548at-5p	86.5043	NM_001100420
C21orf91	hsa-miR-24-2-5p	86.4922	NM_001100420
C21orf91	hsa-miR-371b-5p	85.6613	NM_001100420
C21orf91	hsa-miR-616-5p	85.6613	NM_001100420
C21orf91	hsa-miR-373-5p	85.6613	NM_001100420
C21orf91	hsa-miR-153-3p	85.5527	NM_001100421
C21orf91	hsa-miR-670-3p	85.4945	NM_001100420
C21orf91	hsa-miR-548ba	85.3209	NM_001100420
C21orf91	hsa-miR-410-3p	85.2707	NM_001100420
C21orf91	hsa-miR-3123	85.2496	NM_001100421
C21orf91	hsa-miR-200a-3p	84.9127	NM_001100420
C21orf91	hsa-miR-141-3p	84.9127	NM_001100420
C21orf91	hsa-miR-1273h-3p	84.662	NM_001100421
C21orf91	hsa-miR-548aj-3p	84.569	NM_001100420
C21orf91	hsa-miR-548x-3p	84.569	NM_001100420
C21orf91	hsa-miR-194-5p	84.4404	NM_001100420
C21orf91	hsa-miR-3646	84.4328	NM_001100420
C21orf91	hsa-miR-548ae-3p	84.123	NM_001100420
C21orf91	hsa-miR-548aq-3p	84.123	NM_001100420
C21orf91	hsa-miR-548ah-3p	84.123	NM_001100420
C21orf91	hsa-miR-548am-3p	84.123	NM_001100420
C21orf91	hsa-miR-548j-3p	84.123	NM_001100420
C21orf91	hsa-miR-24-1-5p	83.4739	NM_001100420
C21orf91	hsa-miR-3133	83.4589	NM_001100420
C21orf91	hsa-miR-2052	82.8388	NM_001100420
C21orf91	hsa-miR-548ag	82.8096	NM_001100420
C21orf91	hsa-miR-548ai	82.8096	NM_001100420
C21orf91	hsa-miR-570-5p	82.8096	NM_001100420
C21orf91	hsa-miR-656-3p	82.7707	NM_001100420
C21orf91	hsa-miR-3140-3p	82.7557	NM_001100420

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating C21orf91

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
C21orf91	metacluster_7.13	ZFX (directAnnotation).
C21orf91	cisbp__M01863	ZNF711 (inferredBy_Orthology).
C21orf91	metacluster_151.2	ZNF23 (directAnnotation).
C21orf91	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
C21orf91	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
C21orf91	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
C21orf91	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
C21orf91	transfac_pro__M06071	ZNF814 (directAnnotation).
C21orf91	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
C21orf91	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
C21orf91	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."