Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BTRC

Summary for BTRC

Gene information	Gene symbol	BTRC
	Ensembl ID	ENSG00000166167
	Entrez ID	8945
	Gene name	beta-transducin repeat containing E3 ubiquitin protein ligase
	Synonyms	beta-TrCP1\|betaTrCP\|bTrCP\|bTrCP1\|FBXW1A\|Fwd1
	Gene type	protein_coding
	UniProtAcc	Q9Y297

Top

Dataset with differentially expressed gene: BTRC

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.05058	3.80e-03

Top

Expression of BTRC in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to BTRC

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating BTRC

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BTRC	hsa-miR-149-5p	83.4901	NM_003939
BTRC	hsa-miR-548p	83.2643	NM_003939
BTRC	hsa-miR-4768-5p	82.8418	NM_003939
BTRC	hsa-miR-6873-3p	82.6083	NM_003939
BTRC	hsa-miR-4433a-5p	82.1784	NM_001256856
BTRC	hsa-miR-3529-3p	81.7644	NM_003939
BTRC	hsa-miR-4274	81.729	NM_001256856
BTRC	hsa-miR-3663-5p	81.5078	NM_003939
BTRC	hsa-miR-6780b-5p	81.469	NM_003939
BTRC	hsa-miR-4725-3p	81.469	NM_003939
BTRC	hsa-miR-6732-3p	81.324	NM_001256856
BTRC	hsa-miR-4719	81.0962	NM_001256856
BTRC	hsa-miR-4445-5p	80.9288	NM_003939
BTRC	hsa-miR-6783-3p	80.7331	NM_001256856
BTRC	hsa-miR-1343-3p	80.7331	NM_001256856
BTRC	hsa-miR-4271	80.7003	NM_003939
BTRC	hsa-miR-875-3p	80.3299	NM_001256856
BTRC	hsa-miR-3202	80.2778	NM_003939
BTRC	hsa-miR-6071	80.1232	NM_001256856

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating BTRC

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BTRC	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
BTRC	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
BTRC	transfac_pro__M04617	ZBTB7A (directAnnotation).
BTRC	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
BTRC	transfac_pro__M07387	ZBTB7A (directAnnotation).
BTRC	transfac_pro__M07436	WT1 (directAnnotation).
BTRC	swissregulon__hs__CHD1	CHD1 (directAnnotation).
BTRC	hdpi__HIP2	UBE2K (directAnnotation).
BTRC	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
BTRC	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BTRC	transfac_pro__M03876	ZBTB33 (directAnnotation).
BTRC	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
BTRC	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BTRC	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
BTRC	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BTRC	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."