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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BTBD7

Summary for BTBD7

Gene information	Gene symbol	BTBD7
	Ensembl ID	ENSG00000277222
	Entrez ID	55727
	Gene name	BTB domain containing 7
	Synonyms	FLJ10648\|FUP1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BTBD7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.359042	8.96e-35

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Expression of BTBD7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BTBD7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BTBD7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BTBD7	hsa-miR-4668-3p	88.854	NM_001002860
BTBD7	hsa-miR-539-5p	88.6053	NM_001289133
BTBD7	hsa-miR-4799-3p	88.5544	NM_001002860
BTBD7	hsa-miR-4720-5p	88.5544	NM_001002860
BTBD7	hsa-miR-5588-5p	88.5544	NM_001002860
BTBD7	hsa-miR-34b-3p	88.4512	NM_001002860
BTBD7	hsa-miR-153-3p	88.1195	NM_001002860
BTBD7	hsa-miR-6126	87.6256	NM_001002860
BTBD7	hsa-miR-20b-5p	86.9049	NM_001002860
BTBD7	hsa-miR-17-5p	86.9049	NM_001002860
BTBD7	hsa-miR-519d-3p	86.9049	NM_001002860
BTBD7	hsa-miR-93-5p	86.9049	NM_001002860
BTBD7	hsa-miR-548aj-3p	86.732	NM_001002860
BTBD7	hsa-miR-548x-3p	86.732	NM_001002860
BTBD7	hsa-miR-3664-3p	86.5987	NM_001002860
BTBD7	hsa-let-7c-3p	86.1601	NM_001289133
BTBD7	hsa-miR-5589-3p	86.0537	NM_001289133
BTBD7	hsa-miR-574-5p	85.8479	NM_001002860
BTBD7	hsa-miR-648	85.4764	NM_001002860
BTBD7	hsa-miR-548g-5p	85.077	NM_001002860
BTBD7	hsa-miR-548f-5p	85.077	NM_001002860
BTBD7	hsa-miR-548aj-5p	85.077	NM_001002860
BTBD7	hsa-miR-548x-5p	85.077	NM_001002860
BTBD7	hsa-miR-4789-5p	85.0153	NM_001002860
BTBD7	hsa-miR-8063	84.974	NM_001289133
BTBD7	hsa-miR-657	84.8547	NM_001289133
BTBD7	hsa-miR-548j-3p	84.2818	NM_001002860
BTBD7	hsa-miR-548aq-3p	84.2818	NM_001002860
BTBD7	hsa-miR-548am-3p	84.2818	NM_001002860
BTBD7	hsa-miR-548ah-3p	84.2818	NM_001002860
BTBD7	hsa-miR-548ae-3p	84.2818	NM_001002860
BTBD7	hsa-miR-7154-5p	83.5305	NM_001289133
BTBD7	hsa-miR-573	83.3585	NM_001289133
BTBD7	hsa-miR-3616-5p	83.3585	NM_001289133
BTBD7	hsa-miR-6730-5p	83.0382	NM_001289133
BTBD7	hsa-miR-4697-3p	82.1445	NM_001002860
BTBD7	hsa-miR-520g-5p	81.9012	NM_001289133
BTBD7	hsa-miR-1297	81.7928	NM_001002860
BTBD7	hsa-miR-2115-5p	81.6703	NM_018167
BTBD7	hsa-miR-7849-3p	81.4408	NM_001289133
BTBD7	hsa-miR-4518	81.3647	NM_001002860
BTBD7	hsa-miR-1266-5p	81.3647	NM_001002860
BTBD7	hsa-miR-300	81.1528	NM_001289133
BTBD7	hsa-miR-381-3p	81.1528	NM_001289133
BTBD7	hsa-miR-520d-5p	81.0797	NM_001002860
BTBD7	hsa-miR-524-5p	81.0797	NM_001002860
BTBD7	hsa-miR-194-5p	80.9418	NM_001002860
BTBD7	hsa-miR-1468-3p	80.8099	NM_001002860
BTBD7	hsa-miR-122b-3p	80.7629	NM_001002860
BTBD7	hsa-miR-561-3p	80.6136	NM_001289133

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Motifs and transcription factors (TFs) regulating BTBD7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BTBD7	metacluster_135.11	NR2C2 (directAnnotation).
BTBD7	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BTBD7	tfdimers__MD00038	TFAP2C (directAnnotation).
BTBD7	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BTBD7	metacluster_7.13	ZFX (directAnnotation).
BTBD7	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BTBD7	cisbp__M00968	MTF2 (directAnnotation).
BTBD7	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BTBD7	metacluster_160.20	JUND; PRDM15 (directAnnotation).
BTBD7	cisbp__M00341	PAX6 (directAnnotation).
BTBD7	metacluster_198.3	ZFP64 (directAnnotation).
BTBD7	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
BTBD7	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BTBD7	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BTBD7	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BTBD7	cisbp__M00788	ZFY (inferredBy_Orthology).
BTBD7	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
BTBD7	metacluster_175.1	ZNF283 (directAnnotation).
BTBD7	hdpi__ZNF304	ZNF304 (directAnnotation).
BTBD7	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
BTBD7	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
BTBD7	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BTBD7	transfac_pro__M01199	TRIM28 (directAnnotation).
BTBD7	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
BTBD7	metacluster_151.2	ZNF23 (directAnnotation).
BTBD7	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BTBD7	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BTBD7	transfac_pro__M03806	ZBTB7C (directAnnotation).
BTBD7	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."