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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BAZ2B

Summary for BAZ2B

Gene information	Gene symbol	BAZ2B
	Ensembl ID	ENSG00000123636
	Entrez ID	29994
	Gene name	bromodomain adjacent to zinc finger domain 2B
	Synonyms	WALp4
	Gene type	protein_coding
	UniProtAcc	Q9UIF8

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Dataset with differentially expressed gene: BAZ2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.296416	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.478823	2.06e-29

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Expression of BAZ2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BAZ2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BAZ2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BAZ2B	hsa-miR-92b-3p	87.8053	NM_001289975
BAZ2B	hsa-miR-32-5p	87.8053	NM_001289975
BAZ2B	hsa-miR-92a-3p	87.8053	NM_001289975
BAZ2B	hsa-miR-4999-3p	87.3666	NM_001289975
BAZ2B	hsa-miR-3119	87.2543	NM_001289975
BAZ2B	hsa-miR-490-5p	87.0932	NM_001289975
BAZ2B	hsa-miR-26b-5p	86.9453	NM_001289975
BAZ2B	hsa-miR-26a-5p	86.9453	NM_001289975
BAZ2B	hsa-miR-1252-5p	86.8493	NM_001289975
BAZ2B	hsa-miR-4643	86.2403	NM_001289975
BAZ2B	hsa-miR-5003-5p	86.0809	NM_001289975
BAZ2B	hsa-miR-363-3p	85.701	NM_001289975
BAZ2B	hsa-miR-367-3p	85.701	NM_001289975
BAZ2B	hsa-miR-25-3p	85.701	NM_001289975
BAZ2B	hsa-miR-338-5p	85.6963	NM_001289975
BAZ2B	hsa-miR-543	85.5142	NM_001289975
BAZ2B	hsa-miR-455-5p	85.2483	NM_001289975
BAZ2B	hsa-miR-4465	84.8482	NM_001289975
BAZ2B	hsa-miR-7978	84.6323	NM_001289975
BAZ2B	hsa-miR-3646	84.2492	NM_001289975
BAZ2B	hsa-miR-548ad-3p	84.0682	NM_001289975
BAZ2B	hsa-miR-4649-3p	83.9131	NM_001289975
BAZ2B	hsa-miR-4325	83.8943	NM_001289975
BAZ2B	hsa-miR-7703	83.8943	NM_001289975
BAZ2B	hsa-miR-2355-3p	83.6922	NM_001289975
BAZ2B	hsa-miR-6841-3p	83.6517	NM_001289975
BAZ2B	hsa-miR-6131	83.5815	NM_001289975
BAZ2B	hsa-miR-1208	82.784	NM_001289975
BAZ2B	hsa-miR-7159-3p	81.6286	NM_001289975
BAZ2B	hsa-miR-10b-5p	81.3911	NM_001289975
BAZ2B	hsa-miR-10a-5p	81.3911	NM_001289975
BAZ2B	hsa-miR-12124	81.0508	NM_001289975
BAZ2B	hsa-miR-3663-5p	80.9848	NM_001289975
BAZ2B	hsa-miR-3145-3p	80.8755	NM_001289975
BAZ2B	hsa-miR-4801	80.8069	NM_001289975
BAZ2B	hsa-miR-6843-3p	80.619	NM_001289975
BAZ2B	hsa-miR-6848-3p	80.619	NM_001289975
BAZ2B	hsa-miR-5584-5p	80.5222	NM_001289975

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Motifs and transcription factors (TFs) regulating BAZ2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BAZ2B	metacluster_155.11	SPZ1 (directAnnotation).
BAZ2B	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
BAZ2B	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BAZ2B	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
BAZ2B	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
BAZ2B	hdpi__TIMELESS	TIMELESS (directAnnotation).
BAZ2B	transfac_pro__M04877	GTF3C2 (directAnnotation).
BAZ2B	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
BAZ2B	transfac_public__M00072	TFCP2 (directAnnotation).
BAZ2B	metacluster_160.20	JUND; PRDM15 (directAnnotation).
BAZ2B	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
BAZ2B	tfdimers__MD00167	HIC1; MAFA (directAnnotation).
BAZ2B	hdpi__HTATIP2	HTATIP2 (directAnnotation).
BAZ2B	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
BAZ2B	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BAZ2B	transfac_pro__M12634	ZBTB17 (directAnnotation).
BAZ2B	tfdimers__MD00343	HIC1; TP53 (directAnnotation).
BAZ2B	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
BAZ2B	transfac_pro__M04893	TAF1 (directAnnotation).
BAZ2B	transfac_public__M00005	TFAP4 (directAnnotation).
BAZ2B	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
BAZ2B	hdpi__FEZF2	FEZF2 (directAnnotation).
BAZ2B	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
BAZ2B	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).
BAZ2B	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
BAZ2B	jaspar__MA0131.2	HINFP (directAnnotation).
BAZ2B	metacluster_135.1	ZNF561 (directAnnotation).
BAZ2B	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
BAZ2B	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
BAZ2B	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
BAZ2B	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
BAZ2B	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
BAZ2B	tfdimers__MD00221	FOXG1; FOXO1; GABPA (directAnnotation).
BAZ2B	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
BAZ2B	taipale_tf_pairs__GCM1_CEBPB_MTRSGGGNNNNNTTRCGYAAN_CAP	CEBPB; GCM1 (directAnnotation).
BAZ2B	metacluster_90.3	ESRRA; ESRRA; ESRRB; NR5A1 (directAnnotation). ESRRA; NR5A1; NR5A1; NR5A2; NR5A2 (inferredBy_Orthology).
BAZ2B	transfac_pro__M03821	ESR2 (directAnnotation).
BAZ2B	tfdimers__MD00204	GABPA; NKX2-1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."