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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: B4GALT6

Summary for B4GALT6

Gene information	Gene symbol	B4GALT6
	Ensembl ID	ENSG00000118276
	Entrez ID	9331
	Gene name	beta-1,4-galactosyltransferase 6
	Synonyms	beta4GalT-VI
	Gene type	protein_coding
	UniProtAcc	Q9UBX8

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Dataset with differentially expressed gene: B4GALT6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.39383	1.21e-09

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Expression of B4GALT6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to B4GALT6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating B4GALT6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
B4GALT6	hsa-miR-5688	87.489	NM_004775
B4GALT6	hsa-miR-10397-3p	87.3868	NM_004775
B4GALT6	hsa-miR-6083	87.1274	NM_004775
B4GALT6	hsa-miR-1304-5p	86.4565	NM_004775
B4GALT6	hsa-miR-3143	86.4276	NM_004775
B4GALT6	hsa-miR-655-3p	86.3629	NM_004775
B4GALT6	hsa-miR-374c-5p	86.3629	NM_004775
B4GALT6	hsa-miR-4318	86.3222	NM_004775
B4GALT6	hsa-miR-4659b-3p	86.1251	NM_004775
B4GALT6	hsa-miR-4659a-3p	86.1251	NM_004775
B4GALT6	hsa-miR-4760-3p	85.9663	NM_004775
B4GALT6	hsa-miR-4789-3p	85.9488	NM_004775
B4GALT6	hsa-miR-6887-3p	84.1809	NM_004775
B4GALT6	hsa-miR-3148	83.667	NM_004775
B4GALT6	hsa-miR-300	83.6281	NM_004775
B4GALT6	hsa-miR-381-3p	83.6281	NM_004775
B4GALT6	hsa-miR-216b-5p	83.3075	NM_004775
B4GALT6	hsa-miR-380-3p	83.2605	NM_004775
B4GALT6	hsa-miR-3613-3p	83.0339	NM_004775
B4GALT6	hsa-miR-30e-5p	82.7914	NM_004775
B4GALT6	hsa-miR-4799-5p	82.1155	NM_004775
B4GALT6	hsa-miR-4311	82.0155	NM_004775
B4GALT6	hsa-miR-3682-5p	81.9864	NM_004775
B4GALT6	hsa-miR-5582-3p	81.5597	NM_004775
B4GALT6	hsa-miR-5590-5p	81.5485	NM_004775
B4GALT6	hsa-miR-6507-3p	81.121	NM_004775
B4GALT6	hsa-miR-4703-3p	80.4227	NM_004775
B4GALT6	hsa-miR-377-3p	80.3286	NM_004775
B4GALT6	hsa-miR-30a-5p	80.3269	NM_004775
B4GALT6	hsa-miR-30d-5p	80.3269	NM_004775

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Motifs and transcription factors (TFs) regulating B4GALT6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
B4GALT6	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
B4GALT6	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
B4GALT6	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
B4GALT6	transfac_pro__M04617	ZBTB7A (directAnnotation).
B4GALT6	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
B4GALT6	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
B4GALT6	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
B4GALT6	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
B4GALT6	transfac_pro__M07387	ZBTB7A (directAnnotation).
B4GALT6	transfac_pro__M07436	WT1 (directAnnotation).
B4GALT6	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
B4GALT6	transfac_pro__M00716	ZBTB14 (directAnnotation).
B4GALT6	swissregulon__hs__CHD1	CHD1 (directAnnotation).
B4GALT6	hdpi__HIP2	UBE2K (directAnnotation).
B4GALT6	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
B4GALT6	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
B4GALT6	transfac_pro__M04893	TAF1 (directAnnotation).
B4GALT6	transfac_pro__M03876	ZBTB33 (directAnnotation).
B4GALT6	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
B4GALT6	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
B4GALT6	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
B4GALT6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
B4GALT6	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."