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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AUTS2

Summary for AUTS2

Gene information	Gene symbol	AUTS2
	Ensembl ID	ENSG00000158321
	Entrez ID	26053
	Gene name	activator of transcription and developmental regulator AUTS2
	Synonyms	FBRSL2\|KIAA0442
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AUTS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.363349	0.00e+00

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Expression of AUTS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AUTS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AUTS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AUTS2	hsa-miR-5584-5p	86.4584	NM_001127231
AUTS2	hsa-miR-4317	86.2407	NM_001127231
AUTS2	hsa-miR-4731-3p	85.5465	NM_001127231
AUTS2	hsa-miR-4668-5p	85.3626	NM_001127231
AUTS2	hsa-miR-7151-5p	85.0921	NM_001127231
AUTS2	hsa-miR-5692b	84.958	NM_015570
AUTS2	hsa-miR-5692c	84.958	NM_015570
AUTS2	hsa-miR-1537-5p	84.9474	NM_015570
AUTS2	hsa-miR-1284	84.7006	NM_001127231
AUTS2	hsa-miR-4441	84.4451	NM_001127231
AUTS2	hsa-let-7c-3p	84.345	NM_015570
AUTS2	hsa-miR-6728-5p	83.9659	NM_001127232
AUTS2	hsa-miR-802	83.3099	NM_015570
AUTS2	hsa-miR-4531	83.0685	NM_001127232
AUTS2	hsa-miR-4728-3p	82.9756	NM_001127231
AUTS2	hsa-miR-6508-5p	82.9663	NM_001127231
AUTS2	hsa-miR-4709-3p	82.7667	NM_001127231
AUTS2	hsa-miR-6876-3p	82.6754	NM_001127231
AUTS2	hsa-miR-626	82.6754	NM_001127231
AUTS2	hsa-miR-615-5p	82.6316	NM_015570
AUTS2	hsa-miR-346	81.5478	NM_015570
AUTS2	hsa-miR-1249-5p	81.4613	NM_001127232
AUTS2	hsa-miR-6797-5p	81.4613	NM_001127232
AUTS2	hsa-miR-4270	81.051	NM_001127231
AUTS2	hsa-miR-381-3p	80.8594	NM_001127231
AUTS2	hsa-miR-300	80.8594	NM_001127231
AUTS2	hsa-miR-4779	80.731	NM_001127232
AUTS2	hsa-miR-98-3p	80.4764	NM_001127231
AUTS2	hsa-let-7f-1-3p	80.4764	NM_001127231
AUTS2	hsa-let-7b-3p	80.4764	NM_001127231
AUTS2	hsa-let-7a-3p	80.4764	NM_001127231
AUTS2	hsa-miR-3177-5p	80.086	NM_001127231

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Motifs and transcription factors (TFs) regulating AUTS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AUTS2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
AUTS2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
AUTS2	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
AUTS2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
AUTS2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
AUTS2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
AUTS2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
AUTS2	metacluster_3.14	WT1; WT1 (directAnnotation).
AUTS2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
AUTS2	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."