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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATXN7

Summary for ATXN7

Gene information	Gene symbol	ATXN7
	Ensembl ID	ENSG00000163635
	Entrez ID	6314
	Gene name	ataxin 7
	Synonyms	ADCAII\|OPCA3\|SCA7\|SGF73
	Gene type	protein_coding
	UniProtAcc	O15265

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Dataset with differentially expressed gene: ATXN7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.771691	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.384804	5.14e-36

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Expression of ATXN7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATXN7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATXN7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATXN7	hsa-miR-607	92.0531	NM_000333
ATXN7	hsa-let-7c-3p	91.9901	NM_000333
ATXN7	hsa-miR-5008-5p	91.9627	NM_000333
ATXN7	hsa-miR-4753-3p	91.9201	NM_000333
ATXN7	hsa-miR-12114	91.8291	NM_001177387
ATXN7	hsa-miR-597-5p	91.3532	NM_000333
ATXN7	hsa-miR-224-5p	91.3357	NM_000333
ATXN7	hsa-miR-4698	91.0235	NM_001177387
ATXN7	hsa-miR-3163	90.983	NM_000333
ATXN7	hsa-miR-1206	90.9376	NM_001177387
ATXN7	hsa-miR-375-3p	90.5087	NM_000333
ATXN7	hsa-miR-4780	90.103	NM_000333
ATXN7	hsa-miR-212-5p	90.0874	NM_000333
ATXN7	hsa-miR-3925-3p	89.9646	NM_001177387
ATXN7	hsa-miR-548an	89.5862	NM_000333
ATXN7	hsa-miR-6715b-3p	88.9665	NM_000333
ATXN7	hsa-miR-4645-5p	88.9345	NM_000333
ATXN7	hsa-miR-4673	88.9345	NM_000333
ATXN7	hsa-miR-6867-3p	88.6984	NM_001177387
ATXN7	hsa-miR-345-3p	88.6324	NM_000333
ATXN7	hsa-miR-623	88.6055	NM_000333
ATXN7	hsa-miR-5683	88.6022	NM_000333
ATXN7	hsa-miR-4742-5p	88.447	NM_000333
ATXN7	hsa-miR-2276-3p	88.3007	NM_000333
ATXN7	hsa-miR-1305	88.266	NM_000333
ATXN7	hsa-miR-509-3-5p	87.4537	NM_000333
ATXN7	hsa-miR-509-5p	87.4537	NM_000333
ATXN7	hsa-miR-3121-3p	87.4291	NM_001177387
ATXN7	hsa-miR-6866-3p	87.4082	NM_000333
ATXN7	hsa-miR-8485	87.3468	NM_001177387
ATXN7	hsa-miR-590-3p	87.319	NM_001177387
ATXN7	hsa-miR-6715b-5p	87.2116	NM_000333
ATXN7	hsa-miR-4269	87.2116	NM_000333
ATXN7	hsa-miR-7156-5p	86.7879	NM_001177387
ATXN7	hsa-miR-188-5p	86.6008	NM_000333
ATXN7	hsa-miR-4766-5p	86.5934	NM_000333
ATXN7	hsa-miR-199b-5p	86.5527	NM_000333
ATXN7	hsa-miR-199a-5p	86.5527	NM_000333
ATXN7	hsa-miR-4418	86.5034	NM_000333
ATXN7	hsa-miR-5580-5p	86.4637	NM_000333
ATXN7	hsa-miR-4699-3p	86.413	NM_001128149
ATXN7	hsa-miR-4257	86.3608	NM_000333
ATXN7	hsa-miR-587	86.0169	NM_000333
ATXN7	hsa-miR-511-3p	85.9836	NM_001177387
ATXN7	hsa-miR-4273	85.9748	NM_001177387
ATXN7	hsa-miR-3148	85.6894	NM_000333
ATXN7	hsa-miR-520f-3p	85.6668	NM_000333
ATXN7	hsa-miR-6508-5p	85.5218	NM_001177387
ATXN7	hsa-miR-552-5p	85.4931	NM_001177387
ATXN7	hsa-miR-6739-3p	85.4926	NM_000333

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Motifs and transcription factors (TFs) regulating ATXN7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATXN7	metacluster_7.13	ZFX (directAnnotation).
ATXN7	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ATXN7	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
ATXN7	metacluster_151.2	ZNF23 (directAnnotation).
ATXN7	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ATXN7	transfac_pro__M05479	ZNF580 (directAnnotation).
ATXN7	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ATXN7	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ATXN7	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATXN7	hdpi__ETV4	ETV4 (directAnnotation).
ATXN7	transfac_pro__M06071	ZNF814 (directAnnotation).
ATXN7	jaspar__MA0748.2	YY2 (directAnnotation).
ATXN7	transfac_pro__M05628	ZNF735 (directAnnotation).
ATXN7	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
ATXN7	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ATXN7	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ATXN7	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
ATXN7	jaspar__MA0079.5	SP1 (directAnnotation).
ATXN7	metacluster_135.11	NR2C2 (directAnnotation).
ATXN7	tfdimers__MD00038	TFAP2C (directAnnotation).
ATXN7	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ATXN7	cisbp__M00968	MTF2 (directAnnotation).
ATXN7	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ATXN7	cisbp__M00341	PAX6 (directAnnotation).
ATXN7	metacluster_198.3	ZFP64 (directAnnotation).
ATXN7	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ATXN7	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ATXN7	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ATXN7	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ATXN7	cisbp__M00788	ZFY (inferredBy_Orthology).
ATXN7	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ATXN7	metacluster_175.1	ZNF283 (directAnnotation).
ATXN7	hdpi__ZNF304	ZNF304 (directAnnotation).
ATXN7	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ATXN7	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ATXN7	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ATXN7	transfac_pro__M01199	TRIM28 (directAnnotation).
ATXN7	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ATXN7	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ATXN7	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATXN7	transfac_pro__M03806	ZBTB7C (directAnnotation).
ATXN7	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."