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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATRX

Summary for ATRX

Gene information	Gene symbol	ATRX
	Ensembl ID	ENSG00000085224
	Entrez ID	546
	Gene name	ATRX chromatin remodeler
	Synonyms	JMS\|MRX52\|RAD54\|XH2\|XNP
	Gene type	protein_coding
	UniProtAcc	P46100

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Dataset with differentially expressed gene: ATRX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.27689	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.258485	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.276991	1.06e-35
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.320505	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.337084	2.81e-13
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.276611	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.470336	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.585675	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.367145	1.26e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.385932	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.968263	1.51e-02
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.251936	1.30e-14
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.309809	7.23e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.63009	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.487657	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.442238	0.00e+00

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Expression of ATRX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATRX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATRX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATRX	hsa-miR-512-5p	90.595	NM_000489
ATRX	hsa-miR-4291	90.5636	NM_138270
ATRX	hsa-miR-302d-5p	90.4102	NM_000489
ATRX	hsa-miR-302b-5p	90.4102	NM_000489
ATRX	hsa-miR-3182	90.3623	NM_000489
ATRX	hsa-miR-1303	90.0783	NM_138270
ATRX	hsa-miR-3163	89.6764	NM_138270
ATRX	hsa-miR-3911	89.5824	NM_138270
ATRX	hsa-miR-5680	89.0793	NM_000489
ATRX	hsa-miR-139-5p	88.6858	NM_000489
ATRX	hsa-miR-494-3p	88.6674	NM_138270
ATRX	hsa-miR-363-3p	88.4025	NM_000489
ATRX	hsa-miR-367-3p	88.4025	NM_000489
ATRX	hsa-miR-25-3p	88.4025	NM_000489
ATRX	hsa-miR-98-3p	88.1817	NM_138270
ATRX	hsa-let-7b-3p	88.1817	NM_138270
ATRX	hsa-let-7a-3p	88.1817	NM_138270
ATRX	hsa-let-7f-1-3p	88.1817	NM_138270
ATRX	hsa-miR-1252-3p	87.9924	NM_000489
ATRX	hsa-miR-3129-3p	87.8617	NM_138270
ATRX	hsa-miR-5583-5p	87.8617	NM_138270
ATRX	hsa-miR-345-3p	87.6937	NM_138270
ATRX	hsa-miR-3190-3p	87.6405	NM_000489
ATRX	hsa-miR-32-3p	87.6383	NM_138270
ATRX	hsa-miR-5587-5p	87.571	NM_000489
ATRX	hsa-miR-4705	87.4756	NM_138270
ATRX	hsa-miR-6787-3p	86.8706	NM_000489
ATRX	hsa-miR-101-3p	86.7462	NM_000489
ATRX	hsa-miR-4699-5p	86.7118	NM_000489
ATRX	hsa-miR-4533	86.1136	NM_138270
ATRX	hsa-miR-24-3p	85.7863	NM_138270
ATRX	hsa-miR-3611	85.4222	NM_138270
ATRX	hsa-miR-5583-3p	85.1597	NM_138270
ATRX	hsa-miR-4790-3p	84.9292	NM_138270
ATRX	hsa-miR-6797-5p	84.7653	NM_138270
ATRX	hsa-miR-1249-5p	84.7653	NM_138270
ATRX	hsa-miR-6515-5p	84.3962	NM_000489
ATRX	hsa-miR-186-3p	83.7512	NM_138270
ATRX	hsa-miR-373-5p	83.673	NM_000489
ATRX	hsa-miR-371b-5p	83.673	NM_000489
ATRX	hsa-miR-616-5p	83.673	NM_000489
ATRX	hsa-miR-4726-3p	83.1429	NM_138270
ATRX	hsa-miR-7114-5p	82.9857	NM_138270
ATRX	hsa-miR-607	82.4085	NM_000489
ATRX	hsa-miR-548av-5p	82.2143	NM_000489
ATRX	hsa-miR-8054	82.2143	NM_000489
ATRX	hsa-miR-548k	82.2143	NM_000489
ATRX	hsa-miR-5001-3p	80.993	NM_000489
ATRX	hsa-miR-3973	80.9706	NM_000489
ATRX	hsa-miR-3124-3p	80.7509	NM_138270

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Motifs and transcription factors (TFs) regulating ATRX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATRX	cisbp__M02645	ETS1 (directAnnotation).
ATRX	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
ATRX	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
ATRX	cisbp__M00808	MYPOP (inferredBy_Orthology).
ATRX	hdpi__TP73	TP73 (directAnnotation).
ATRX	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATRX	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ATRX	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ATRX	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ATRX	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ATRX	cisbp__M00788	ZFY (inferredBy_Orthology).
ATRX	hdpi__ZNF304	ZNF304 (directAnnotation).
ATRX	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
ATRX	metacluster_141.2	E2F2; E2F3 (directAnnotation).
ATRX	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ATRX	jaspar__MA0748.2	YY2 (directAnnotation).
ATRX	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
ATRX	metacluster_182.10	ZFX (directAnnotation).
ATRX	transfac_pro__M06833	PEG3 (directAnnotation).
ATRX	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
ATRX	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ATRX	transfac_pro__M04748	GABPA (directAnnotation).
ATRX	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ATRX	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
ATRX	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
ATRX	transfac_pro__M06032	ZNF727 (directAnnotation).
ATRX	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
ATRX	metacluster_141.4	GLIS2 (directAnnotation).
ATRX	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
ATRX	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
ATRX	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
ATRX	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
ATRX	transfac_pro__M06259	ZNF91 (directAnnotation).
ATRX	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
ATRX	transfac_pro__M06724	ZNF331 (directAnnotation).
ATRX	hdpi__FEZF2	FEZF2 (directAnnotation).
ATRX	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ATRX	hdpi__RARA	RARA (directAnnotation).
ATRX	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ATRX	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ATRX	metacluster_45.4	E2F2 (directAnnotation).
ATRX	transfac_pro__M00430	E2F1 (directAnnotation).
ATRX	hdpi__GTF3C2	GTF3C2 (directAnnotation).
ATRX	jaspar__MA1721.1	ZNF93 (directAnnotation).
ATRX	transfac_pro__M04646	FOXN4 (directAnnotation).
ATRX	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
ATRX	cisbp__M00249	WT1 (directAnnotation).
ATRX	cisbp__M00809	PRDM11 (inferredBy_Orthology).
ATRX	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."