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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATRN

Summary for ATRN

Gene information	Gene symbol	ATRN
	Ensembl ID	ENSG00000088812
	Entrez ID	8455
	Gene name	attractin
	Synonyms	DPPT-L\|MGCA
	Gene type	protein_coding
	UniProtAcc	O75882

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Dataset with differentially expressed gene: ATRN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.50971	1.64e-03

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Expression of ATRN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATRN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATRN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATRN	hsa-miR-202-5p	85.7759	NM_139321
ATRN	hsa-miR-30a-5p	85.5346	NM_139321
ATRN	hsa-miR-30c-5p	85.5346	NM_139321
ATRN	hsa-miR-30b-5p	85.5346	NM_139321
ATRN	hsa-miR-30e-5p	85.5346	NM_139321
ATRN	hsa-miR-30d-5p	85.5346	NM_139321
ATRN	hsa-miR-4471	85.3003	NM_139321
ATRN	hsa-miR-9983-3p	85.148	NM_139321
ATRN	hsa-miR-2113	85.0392	NM_139321
ATRN	hsa-miR-767-5p	84.8591	NM_139321
ATRN	hsa-miR-302c-5p	84.5515	NM_139322
ATRN	hsa-miR-6818-5p	84.5372	NM_139321
ATRN	hsa-miR-6841-5p	84.5194	NM_139322
ATRN	hsa-miR-5187-5p	84.4995	NM_139321
ATRN	hsa-miR-297	84.2256	NM_139321
ATRN	hsa-miR-3192-5p	83.4318	NM_139321
ATRN	hsa-miR-1343-3p	83.4301	NM_139321
ATRN	hsa-miR-1207-5p	83.2094	NM_139321
ATRN	hsa-miR-8059	82.8133	NM_139321
ATRN	hsa-miR-5586-5p	82.2995	NM_139321
ATRN	hsa-miR-381-3p	82.2404	NM_139321
ATRN	hsa-miR-300	82.2404	NM_139321
ATRN	hsa-miR-6882-5p	82.2042	NM_139321
ATRN	hsa-miR-129-5p	82.1766	NM_139321
ATRN	hsa-miR-659-5p	82.0506	NM_139321
ATRN	hsa-miR-6837-3p	81.8358	NM_139321
ATRN	hsa-miR-4763-3p	81.5055	NM_139321
ATRN	hsa-miR-4725-3p	81.3115	NM_001323332
ATRN	hsa-miR-6780b-5p	81.3115	NM_001323332
ATRN	hsa-miR-100-3p	81.1029	NM_139321
ATRN	hsa-miR-3191-5p	80.9589	NM_001323332
ATRN	hsa-miR-23b-3p	80.9068	NM_139321
ATRN	hsa-miR-23a-3p	80.9068	NM_139321
ATRN	hsa-miR-23c	80.9068	NM_139321
ATRN	hsa-miR-567	80.8802	NM_139321
ATRN	hsa-miR-6861-3p	80.8449	NM_139321
ATRN	hsa-miR-12135	80.7066	NM_139321
ATRN	hsa-miR-760	80.5725	NM_139321
ATRN	hsa-miR-6761-5p	80.3001	NM_139321

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Motifs and transcription factors (TFs) regulating ATRN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATRN	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."