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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ATP8A1

Summary for ATP8A1

Gene information	Gene symbol	ATP8A1
	Ensembl ID	ENSG00000124406
	Entrez ID	10396
	Gene name	ATPase phospholipid transporting 8A1
	Synonyms	ATPIA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATP8A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.287795	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.261094	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.42378	4.72e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.267309	8.37e-39
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.301446	0.00e+00

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Expression of ATP8A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP8A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP8A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP8A1	hsa-miR-135b-5p	89.7023	NM_001105529
ATP8A1	hsa-miR-135a-5p	89.7023	NM_001105529
ATP8A1	hsa-miR-4760-3p	89.6672	NM_001105529
ATP8A1	hsa-miR-6726-5p	89.3139	NM_001105529
ATP8A1	hsa-miR-920	89.3139	NM_001105529
ATP8A1	hsa-miR-5591-5p	89.1517	NM_001105529
ATP8A1	hsa-miR-4300	89.1517	NM_001105529
ATP8A1	hsa-miR-4796-5p	88.7031	NM_001105529
ATP8A1	hsa-miR-4482-3p	88.3872	NM_001105529
ATP8A1	hsa-miR-3160-3p	88.2782	NM_001105529
ATP8A1	hsa-miR-4471	87.7505	NM_001105529
ATP8A1	hsa-miR-4297	87.5973	NM_001105529
ATP8A1	hsa-miR-4422	87.0443	NM_001105529
ATP8A1	hsa-miR-3613-3p	87.0175	NM_001105529
ATP8A1	hsa-miR-8059	86.5301	NM_001105529
ATP8A1	hsa-miR-5195-3p	86.5168	NM_001105529
ATP8A1	hsa-miR-145-5p	86.5168	NM_001105529
ATP8A1	hsa-miR-3125	86.1528	NM_001105529
ATP8A1	hsa-miR-4291	86.1374	NM_001105529
ATP8A1	hsa-miR-5100	86.0203	NM_001105529
ATP8A1	hsa-miR-539-5p	85.9926	NM_001105529
ATP8A1	hsa-miR-5189-5p	85.7171	NM_001105529
ATP8A1	hsa-miR-1285-3p	85.7171	NM_001105529
ATP8A1	hsa-miR-3164	85.6851	NM_001105529
ATP8A1	hsa-miR-6820-3p	85.6851	NM_001105529
ATP8A1	hsa-miR-6859-5p	85.3402	NM_001105529
ATP8A1	hsa-miR-3916	85.3402	NM_001105529
ATP8A1	hsa-miR-6833-3p	84.8206	NM_001105529
ATP8A1	hsa-miR-612	84.7016	NM_001105529
ATP8A1	hsa-miR-6860	84.5005	NM_001105529
ATP8A1	hsa-miR-3187-5p	84.5005	NM_001105529
ATP8A1	hsa-miR-7850-5p	84.3582	NM_001105529
ATP8A1	hsa-miR-3124-3p	83.8666	NM_001105529
ATP8A1	hsa-miR-888-5p	83.7199	NM_001105529
ATP8A1	hsa-miR-8066	83.2773	NM_001105529
ATP8A1	hsa-miR-3714	83.1506	NM_001105529
ATP8A1	hsa-miR-548av-3p	83.1263	NM_001105529
ATP8A1	hsa-miR-7-2-3p	82.9304	NM_001105529
ATP8A1	hsa-miR-7-1-3p	82.9304	NM_001105529
ATP8A1	hsa-miR-4768-5p	82.7617	NM_001105529
ATP8A1	hsa-miR-152-3p	82.6893	NM_001105529
ATP8A1	hsa-miR-148b-3p	82.6893	NM_001105529
ATP8A1	hsa-miR-148a-3p	82.6893	NM_001105529
ATP8A1	hsa-miR-5197-5p	82.4505	NM_001105529
ATP8A1	hsa-miR-203b-3p	82.4057	NM_001105529
ATP8A1	hsa-miR-4455	82.2359	NM_001105529
ATP8A1	hsa-miR-12113	82.2222	NM_001105529
ATP8A1	hsa-miR-4539	82.2222	NM_001105529
ATP8A1	hsa-miR-532-5p	82.1465	NM_001105529
ATP8A1	hsa-miR-6852-3p	82.1348	NM_001105529

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Motifs and transcription factors (TFs) regulating ATP8A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP8A1	jaspar__MA0748.2	YY2 (directAnnotation).
ATP8A1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ATP8A1	cisbp__M00788	ZFY (inferredBy_Orthology).
ATP8A1	metacluster_7.13	ZFX (directAnnotation).
ATP8A1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ATP8A1	hdpi__HIP2	UBE2K (directAnnotation).
ATP8A1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ATP8A1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ATP8A1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ATP8A1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATP8A1	transfac_pro__M02898	SMAD3 (directAnnotation).
ATP8A1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ATP8A1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ATP8A1	hdpi__TIMELESS	TIMELESS (directAnnotation).
ATP8A1	transfac_pro__M04893	TAF1 (directAnnotation).
ATP8A1	cisbp__M00249	WT1 (directAnnotation).
ATP8A1	transfac_pro__M00430	E2F1 (directAnnotation).
ATP8A1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ATP8A1	hdpi__ZNF304	ZNF304 (directAnnotation).
ATP8A1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ATP8A1	transfac_pro__M00938	E2F1 (directAnnotation).
ATP8A1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ATP8A1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ATP8A1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ATP8A1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ATP8A1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ATP8A1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ATP8A1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ATP8A1	transfac_pro__M01199	TRIM28 (directAnnotation).
ATP8A1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATP8A1	tfdimers__MD00038	TFAP2C (directAnnotation).
ATP8A1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ATP8A1	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
ATP8A1	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
ATP8A1	tfdimers__MD00026	IRF1; MYB (directAnnotation).
ATP8A1	jaspar__MA1509.1	IRF6 (directAnnotation).
ATP8A1	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
ATP8A1	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
ATP8A1	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).
ATP8A1	transfac_pro__M04883	TCF12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ATP8A1	"Phosphatidyl serine"	DB00144	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."