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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ATF7IP

Summary for ATF7IP

Gene information	Gene symbol	ATF7IP
	Ensembl ID	ENSG00000171681
	Entrez ID	55729
	Gene name	activating transcription factor 7 interacting protein
	Synonyms	ATF7IP1\|FLJ10688\|p621
	Gene type	protein_coding
	UniProtAcc	Q6VMQ6

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Dataset with differentially expressed gene: ATF7IP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.359319	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.330479	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.419847	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.259808	1.75e-27
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.264907	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.455785	4.65e-21
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.315832	2.00e-20

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Expression of ATF7IP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATF7IP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATF7IP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATF7IP	hsa-miR-224-3p	87.4281	NM_001286514
ATF7IP	hsa-miR-12114	87.4281	NM_181352
ATF7IP	hsa-miR-875-3p	87.2365	NM_181352
ATF7IP	hsa-miR-539-5p	87.0556	NM_001286514
ATF7IP	hsa-miR-140-3p	87.0337	NM_001286514
ATF7IP	hsa-miR-548x-3p	86.4595	NM_001286514
ATF7IP	hsa-miR-548aj-3p	86.4595	NM_001286514
ATF7IP	hsa-miR-450b-5p	86.2951	NM_001286515
ATF7IP	hsa-miR-6771-3p	86.126	NM_181352
ATF7IP	hsa-miR-590-3p	86.1195	NM_181352
ATF7IP	hsa-miR-4433b-5p	85.4704	NM_001286514
ATF7IP	hsa-miR-3133	85.34	NM_181352
ATF7IP	hsa-miR-7159-3p	85.0698	NM_001286515
ATF7IP	hsa-miR-607	84.0994	NM_181352
ATF7IP	hsa-miR-6128	84.0923	NM_181352
ATF7IP	hsa-miR-5002-5p	83.795	NM_181352
ATF7IP	hsa-miR-1283	83.3882	NM_001286514
ATF7IP	hsa-miR-9851-3p	83.2576	NM_001286514
ATF7IP	hsa-miR-9983-3p	82.6436	NM_001286515
ATF7IP	hsa-miR-548ah-3p	82.5095	NM_001286514
ATF7IP	hsa-miR-548am-3p	82.5095	NM_001286514
ATF7IP	hsa-miR-548j-3p	82.5095	NM_001286514
ATF7IP	hsa-miR-548aq-3p	82.5095	NM_001286514
ATF7IP	hsa-miR-548ae-3p	82.5095	NM_001286514
ATF7IP	hsa-miR-381-3p	82.3709	NM_001286515
ATF7IP	hsa-miR-300	82.3709	NM_001286515
ATF7IP	hsa-miR-4775	81.8655	NM_181352
ATF7IP	hsa-miR-452-3p	81.6936	NM_181352
ATF7IP	hsa-miR-548e-5p	81.6242	NM_181352
ATF7IP	hsa-miR-129-5p	81.2597	NM_001286515
ATF7IP	hsa-miR-196a-1-3p	81.1293	NM_181352
ATF7IP	hsa-miR-4531	81.1117	NM_181352
ATF7IP	hsa-miR-580-3p	80.9454	NM_001286514
ATF7IP	hsa-miR-6833-3p	80.573	NM_001286514
ATF7IP	hsa-miR-216b-3p	80.4598	NM_001286514
ATF7IP	hsa-miR-593-5p	80.2903	NM_001286514

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Motifs and transcription factors (TFs) regulating ATF7IP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATF7IP	metacluster_135.11	NR2C2 (directAnnotation).
ATF7IP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ATF7IP	cisbp__M00968	MTF2 (directAnnotation).
ATF7IP	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ATF7IP	metacluster_198.3	ZFP64 (directAnnotation).
ATF7IP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ATF7IP	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ATF7IP	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ATF7IP	metacluster_175.1	ZNF283 (directAnnotation).
ATF7IP	hdpi__ZNF304	ZNF304 (directAnnotation).
ATF7IP	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ATF7IP	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ATF7IP	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ATF7IP	transfac_pro__M01199	TRIM28 (directAnnotation).
ATF7IP	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ATF7IP	metacluster_151.2	ZNF23 (directAnnotation).
ATF7IP	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ATF7IP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATF7IP	transfac_pro__M03806	ZBTB7C (directAnnotation).
ATF7IP	hdpi__NRL	NRL (directAnnotation).
ATF7IP	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ATF7IP	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ATF7IP	hdpi__FEZF2	FEZF2 (directAnnotation).
ATF7IP	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
ATF7IP	transfac_pro__M07310	SP5 (directAnnotation).
ATF7IP	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ATF7IP	metacluster_155.11	SPZ1 (directAnnotation).
ATF7IP	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ATF7IP	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ATF7IP	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ATF7IP	hdpi__HIP2	UBE2K (directAnnotation).
ATF7IP	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
ATF7IP	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ATF7IP	transfac_pro__M02089	E2F3 (directAnnotation).
ATF7IP	cisbp__M07938	E2F1 (directAnnotation).
ATF7IP	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
ATF7IP	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ATF7IP	transfac_pro__M04817	ZBTB33 (directAnnotation).
ATF7IP	tfdimers__MD00483	ZBTB14 (directAnnotation).
ATF7IP	transfac_pro__M07317	CTBP1 (directAnnotation).
ATF7IP	transfac_pro__M12697	ZNF142 (directAnnotation).
ATF7IP	transfac_pro__M00716	ZBTB14 (directAnnotation).
ATF7IP	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ATF7IP	transfac_pro__M04893	TAF1 (directAnnotation).
ATF7IP	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ATF7IP	transfac_pro__M01783	SP2 (directAnnotation).
ATF7IP	transfac_pro__M04916	TAF1 (directAnnotation).
ATF7IP	hdpi__RARA	RARA (directAnnotation).
ATF7IP	jaspar__MA1650.1	ZBTB14 (directAnnotation).
ATF7IP	cisbp__M08228	PAX5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."