Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ASAP2

Summary for ASAP2

Gene information	Gene symbol	ASAP2
	Ensembl ID	ENSG00000151693
	Entrez ID	8853
	Gene name	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
	Synonyms	CENTB3\|DDEF2\|KIAA0400\|PAP\|SHAG1
	Gene type	protein_coding
	UniProtAcc	O43150

Top

Dataset with differentially expressed gene: ASAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.61804	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.324493	3.22e-16

Top

Expression of ASAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ASAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ASAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ASAP2	hsa-miR-409-3p	86.0015	NM_001135191
ASAP2	hsa-miR-3148	85.8231	NM_001135191
ASAP2	hsa-miR-8082	85.8119	NM_001135191
ASAP2	hsa-miR-539-3p	85.689	NM_001135191
ASAP2	hsa-miR-485-3p	85.689	NM_001135191
ASAP2	hsa-miR-203b-3p	85.6024	NM_001135191
ASAP2	hsa-miR-4666a-3p	85.3066	NM_001135191
ASAP2	hsa-miR-4803	85.1914	NM_001135191
ASAP2	hsa-miR-7853-5p	84.8297	NM_001135191
ASAP2	hsa-miR-105-5p	84.8297	NM_001135191
ASAP2	hsa-miR-12132	84.7526	NM_001135191
ASAP2	hsa-miR-4473	84.4879	NM_001135191
ASAP2	hsa-miR-5683	84.1885	NM_001135191
ASAP2	hsa-miR-3126-3p	83.9778	NM_001135191
ASAP2	hsa-miR-513c-3p	83.4911	NM_001135191
ASAP2	hsa-miR-513a-3p	83.4911	NM_001135191
ASAP2	hsa-miR-548aw	83.4046	NM_001135191
ASAP2	hsa-miR-936	83.1631	NM_001135191
ASAP2	hsa-miR-4772-3p	82.6768	NM_001135191
ASAP2	hsa-miR-4328	82.594	NM_001135191
ASAP2	hsa-miR-4682	82.5344	NM_001135191
ASAP2	hsa-miR-4463	82.4133	NM_001135191
ASAP2	hsa-miR-98-3p	82.1446	NM_001135191
ASAP2	hsa-let-7b-3p	82.1446	NM_001135191
ASAP2	hsa-let-7a-3p	82.1446	NM_001135191
ASAP2	hsa-let-7f-1-3p	82.1446	NM_001135191
ASAP2	hsa-miR-4422	81.9572	NM_001135191
ASAP2	hsa-miR-3606-3p	81.8742	NM_001135191
ASAP2	hsa-miR-8060	81.7729	NM_001135191
ASAP2	hsa-miR-5583-5p	81.5102	NM_001135191
ASAP2	hsa-miR-3129-3p	81.5102	NM_001135191
ASAP2	hsa-miR-6740-5p	80.9284	NM_001135191
ASAP2	hsa-miR-101-2-5p	80.1382	NM_001135191
ASAP2	hsa-miR-9851-3p	80.134	NM_001135191

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating ASAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ASAP2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ASAP2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ASAP2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ASAP2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
ASAP2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ASAP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ASAP2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ASAP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ASAP2	transfac_pro__M00652	NRF1 (directAnnotation).
ASAP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ASAP2	transfac_pro__M04866	HDAC2 (directAnnotation).
ASAP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
ASAP2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ASAP2	jaspar__MA0079.5	SP1 (directAnnotation).
ASAP2	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ASAP2	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
ASAP2	transfac_pro__M01253	CNOT3 (directAnnotation).
ASAP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
ASAP2	cisbp__M07938	E2F1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."