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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARRDC3

Summary for ARRDC3

Gene information	Gene symbol	ARRDC3
	Ensembl ID	ENSG00000113369
	Entrez ID	57561
	Gene name	arrestin domain containing 3
	Synonyms	KIAA1376\|TLIMP
	Gene type	protein_coding
	UniProtAcc	Q96B67

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Dataset with differentially expressed gene: ARRDC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.866633	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.330475	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.632967	2.72e-40
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.616746	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.434299	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.300946	5.19e-25
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.253816	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.365721	4.57e-18
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.346625	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.302366	1.95e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.349695	2.54e-21
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.275279	7.25e-10
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.321552	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	B cells	0.445889	9.13e-27

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Expression of ARRDC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARRDC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARRDC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARRDC3	hsa-miR-381-3p	84.4505	NM_020801
ARRDC3	hsa-miR-300	84.4505	NM_020801
ARRDC3	hsa-miR-374a-3p	84.3414	NM_020801
ARRDC3	hsa-miR-4325	83.7185	NM_020801
ARRDC3	hsa-miR-2115-3p	83.6496	NM_020801
ARRDC3	hsa-miR-3692-3p	83.2579	NM_020801
ARRDC3	hsa-miR-138-5p	83.2157	NM_020801
ARRDC3	hsa-miR-378g	82.0777	NM_020801
ARRDC3	hsa-miR-325	82.0293	NM_020801
ARRDC3	hsa-miR-6868-3p	82.0077	NM_020801
ARRDC3	hsa-miR-6077	81.9427	NM_020801
ARRDC3	hsa-miR-4486	81.3138	NM_020801
ARRDC3	hsa-miR-4698	81.0687	NM_020801
ARRDC3	hsa-miR-4645-5p	81.0207	NM_020801
ARRDC3	hsa-miR-3149	80.6516	NM_020801
ARRDC3	hsa-miR-7850-5p	80.604	NM_020801
ARRDC3	hsa-miR-561-3p	80.463	NM_020801
ARRDC3	hsa-miR-642b-5p	80.2543	NM_020801
ARRDC3	hsa-miR-5695	80.1092	NM_020801
ARRDC3	hsa-miR-5010-3p	80.0642	NM_020801

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Motifs and transcription factors (TFs) regulating ARRDC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARRDC3	transfac_pro__M05916	ZNF407 (directAnnotation).
ARRDC3	transfac_pro__M06751	ZNF510 (directAnnotation).
ARRDC3	transfac_pro__M06117	ZNF23 (directAnnotation).
ARRDC3	metacluster_162.5	NR1D1; NR1D1; RORA; RORA; RORA; RORA; RORA; RORC; RORC (directAnnotation). NR1D1; PPARG; RORA; RORC (inferredBy_Orthology).
ARRDC3	tfdimers__MD00433	NKX3-2; ZNF217 (directAnnotation).
ARRDC3	transfac_public__M00123	MAX; MYC (directAnnotation).
ARRDC3	taipale_tf_pairs__TCF15_NACAYATGNN_HT	TCF15 (directAnnotation).
ARRDC3	taipale_tf_pairs__HOXB2_TBX3_AGGTGTTAATKN_CAP	HOXB2; TBX3 (directAnnotation).
ARRDC3	tfdimers__MD00463	CHURC1; DBP (directAnnotation).
ARRDC3	cisbp__M00262	ARX (directAnnotation).
ARRDC3	jaspar__MA0039.4	KLF4 (directAnnotation).
ARRDC3	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
ARRDC3	transfac_pro__M04595	SALL2 (directAnnotation).
ARRDC3	transfac_pro__M04862	NRF1 (directAnnotation).
ARRDC3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ARRDC3	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
ARRDC3	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
ARRDC3	transfac_pro__M04748	GABPA (directAnnotation).
ARRDC3	hocomoco__HSFY1_HUMAN.H11MO.0.D	HSFY1; HSFY2 (directAnnotation).
ARRDC3	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
ARRDC3	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
ARRDC3	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
ARRDC3	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
ARRDC3	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
ARRDC3	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
ARRDC3	jaspar__MA1125.1	ZNF384 (directAnnotation).
ARRDC3	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
ARRDC3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ARRDC3	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
ARRDC3	tfdimers__MD00069	IKZF1; PDX1 (directAnnotation).
ARRDC3	transfac_pro__M04916	TAF1 (directAnnotation).
ARRDC3	cisbp__M01174	OSR1 (inferredBy_Orthology).
ARRDC3	transfac_pro__M05521	ZNF398 (directAnnotation).
ARRDC3	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
ARRDC3	transfac_pro__M06237	ZNF846 (directAnnotation).
ARRDC3	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
ARRDC3	tfdimers__MD00218	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM; ELF1 (directAnnotation).
ARRDC3	transfac_pro__M05715	ZNF133 (directAnnotation).
ARRDC3	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
ARRDC3	taipale_tf_pairs__HOXB2_HOXB13_NNMATCACATAAAN_CAP_repr	HOXB13; HOXB2 (directAnnotation).
ARRDC3	transfac_pro__M05619	ZSCAN5C (directAnnotation).
ARRDC3	jaspar__MA1563.2	SOX18 (directAnnotation).
ARRDC3	jaspar__MA1983.1	ZNF582 (directAnnotation).
ARRDC3	hocomoco__ZBT14_HUMAN.H11MO.0.C	ZBTB14 (directAnnotation).
ARRDC3	nitta__Ets98B_TTCTAG20NTA_KI_TAMCGGATGC_m2_c4	SPDEF (inferredBy_Orthology).
ARRDC3	taipale_tf_pairs__GCM1_FOXI1_TGTTGANGCGGGN_CAP	FOXI1; GCM1 (directAnnotation).
ARRDC3	transfac_pro__M06071	ZNF814 (directAnnotation).
ARRDC3	metacluster_45.4	E2F2 (directAnnotation).
ARRDC3	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
ARRDC3	taipale_tf_pairs__GCM1_FOXI1_NTGTTGATRNGGGN_CAP_repr	FOXI1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."