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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ARL5A

Summary for ARL5A

Gene information	Gene symbol	ARL5A
	Ensembl ID	ENSG00000162980
	Entrez ID	26225
	Gene name	ADP ribosylation factor like GTPase 5A
	Synonyms	ARL5
	Gene type	protein_coding
	UniProtAcc	Q9Y689

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Dataset with differentially expressed gene: ARL5A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.277298	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.259456	5.04e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.298549	4.44e-05
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.278024	8.75e-03
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.377402	5.59e-30
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.504723	1.18e-32
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.285118	5.78e-14
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.323267	1.20e-13
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.30945	0.00e+00

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Expression of ARL5A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARL5A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARL5A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARL5A	hsa-miR-197-5p	84.691	NM_012097
ARL5A	hsa-let-7c-5p	84.2328	NM_001037174
ARL5A	hsa-let-7f-5p	84.2328	NM_001037174
ARL5A	hsa-let-7e-5p	84.2328	NM_001037174
ARL5A	hsa-let-7i-5p	84.2328	NM_001037174
ARL5A	hsa-let-7b-5p	84.2328	NM_001037174
ARL5A	hsa-let-7a-5p	84.2328	NM_001037174
ARL5A	hsa-miR-98-5p	84.2328	NM_001037174
ARL5A	hsa-let-7g-5p	84.2328	NM_001037174
ARL5A	hsa-miR-3613-3p	83.5426	NM_001037174
ARL5A	hsa-miR-4660	83.1245	NM_012097
ARL5A	hsa-miR-1305	83.0893	NM_012097
ARL5A	hsa-miR-181a-5p	82.7485	NM_001037174
ARL5A	hsa-miR-181d-5p	82.7485	NM_001037174
ARL5A	hsa-miR-181c-5p	82.7485	NM_001037174
ARL5A	hsa-miR-181b-5p	82.7485	NM_001037174
ARL5A	hsa-miR-548aq-3p	82.4406	NM_012097
ARL5A	hsa-miR-548x-3p	82.4406	NM_012097
ARL5A	hsa-miR-548ah-3p	82.4406	NM_012097
ARL5A	hsa-miR-548j-3p	82.4406	NM_012097
ARL5A	hsa-miR-548am-3p	82.4406	NM_012097
ARL5A	hsa-miR-548ae-3p	82.4406	NM_012097
ARL5A	hsa-miR-548aj-3p	82.4406	NM_012097
ARL5A	hsa-miR-32-3p	82.2	NM_012097
ARL5A	hsa-miR-1231	81.9482	NM_012097
ARL5A	hsa-miR-136-5p	81.849	NM_012097
ARL5A	hsa-miR-335-3p	81.7917	NM_012097
ARL5A	hsa-miR-548aa	81.2684	NM_001037174
ARL5A	hsa-miR-548ap-3p	81.2684	NM_001037174
ARL5A	hsa-miR-548t-3p	81.2684	NM_001037174
ARL5A	hsa-miR-9-3p	81.0798	NM_001037174
ARL5A	hsa-miR-8080	80.8898	NM_012097
ARL5A	hsa-miR-192-3p	80.4909	NM_012097
ARL5A	hsa-miR-4458	80.273	NM_001037174
ARL5A	hsa-let-7d-5p	80.273	NM_001037174

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Motifs and transcription factors (TFs) regulating ARL5A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARL5A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ARL5A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARL5A	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ARL5A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ARL5A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ARL5A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ARL5A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARL5A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ARL5A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ARL5A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARL5A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ARL5A	transfac_pro__M01714	KLF15 (directAnnotation).
ARL5A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ARL5A	transfac_pro__M02089	E2F3 (directAnnotation).
ARL5A	metacluster_3.14	WT1; WT1 (directAnnotation).
ARL5A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ARL5A	cisbp__M07938	E2F1 (directAnnotation).
ARL5A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ARL5A	transfac_pro__M07436	WT1 (directAnnotation).
ARL5A	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ARL5A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARL5A	transfac_pro__M02898	SMAD3 (directAnnotation).
ARL5A	transfac_public__M00491	PATZ1 (directAnnotation).
ARL5A	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ARL5A	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ARL5A	transfac_pro__M04826	EP300 (directAnnotation).
ARL5A	hdpi__ETV4	ETV4 (directAnnotation).
ARL5A	swissregulon__hs__ELK1	ELK1 (directAnnotation).
ARL5A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ARL5A	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ARL5A	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ARL5A	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ARL5A	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
ARL5A	transfac_pro__M00492	STAT1 (directAnnotation).
ARL5A	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ARL5A	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
ARL5A	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
ARL5A	metacluster_14.20	TFEB (directAnnotation).
ARL5A	metacluster_14.12	ARNT; MAX; USF1 (directAnnotation).
ARL5A	metacluster_14.13	MAX; USF1; USF1 (directAnnotation).
ARL5A	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
ARL5A	metacluster_57.2	BACH1; MITF; MITF; TFE3; TFE3; TFE3; TFEB; USF2 (directAnnotation). MITF; TFE3; USF1; USF2 (inferredBy_Orthology).
ARL5A	transfac_pro__M06332	ZNF585A (directAnnotation).
ARL5A	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
ARL5A	transfac_pro__M05354	ZNF800 (inferredBy_Orthology).
ARL5A	swissregulon__hs__OVOL1	OVOL1 (directAnnotation).
ARL5A	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
ARL5A	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
ARL5A	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
ARL5A	transfac_pro__M05868	ZNF491 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ARL5A	"Guanosine-5'-Diphosphate"	DB04315	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."